PMC:7243778 / 13856-14673 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"326","span":{"begin":306,"end":310},"obj":"Gene"},{"id":"327","span":{"begin":384,"end":385},"obj":"Gene"},{"id":"328","span":{"begin":550,"end":551},"obj":"Gene"},{"id":"329","span":{"begin":28,"end":33},"obj":"Species"},{"id":"330","span":{"begin":72,"end":77},"obj":"Species"},{"id":"331","span":{"begin":594,"end":602},"obj":"Species"},{"id":"332","span":{"begin":180,"end":183},"obj":"CellLine"},{"id":"333","span":{"begin":760,"end":763},"obj":"CellLine"}],"attributes":[{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"Gene:59272"},{"id":"A327","pred":"tao:has_database_id","subj":"327","obj":"Gene:43740575"},{"id":"A328","pred":"tao:has_database_id","subj":"328","obj":"Gene:43740568"},{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"Tax:10090"},{"id":"A330","pred":"tao:has_database_id","subj":"330","obj":"Tax:9606"},{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Tax:694009"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"CVCL:G696"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"CVCL:G696"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T60","span":{"begin":34,"end":48},"obj":"Body_part"},{"id":"T61","span":{"begin":78,"end":92},"obj":"Body_part"},{"id":"T62","span":{"begin":488,"end":499},"obj":"Body_part"},{"id":"T63","span":{"begin":552,"end":559},"obj":"Body_part"},{"id":"T64","span":{"begin":653,"end":661},"obj":"Body_part"}],"attributes":[{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T49","span":{"begin":594,"end":602},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T157","span":{"begin":28,"end":33},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T158","span":{"begin":49,"end":54},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T159","span":{"begin":69,"end":77},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T160","span":{"begin":93,"end":98},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T161","span":{"begin":127,"end":129},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T162","span":{"begin":142,"end":144},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T163","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0001435"},{"id":"T164","span":{"begin":264,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T165","span":{"begin":285,"end":290},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T166","span":{"begin":358,"end":360},"obj":"http://purl.obolibrary.org/obo/CLO_0001627"},{"id":"T167","span":{"begin":503,"end":505},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T168","span":{"begin":644,"end":646},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T169","span":{"begin":650,"end":652},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T170","span":{"begin":650,"end":652},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T171","span":{"begin":675,"end":677},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T71","span":{"begin":349,"end":356},"obj":"Chemical"},{"id":"T72","span":{"begin":488,"end":499},"obj":"Chemical"},{"id":"T73","span":{"begin":488,"end":493},"obj":"Chemical"},{"id":"T74","span":{"begin":494,"end":499},"obj":"Chemical"},{"id":"T75","span":{"begin":552,"end":559},"obj":"Chemical"},{"id":"T76","span":{"begin":650,"end":652},"obj":"Chemical"},{"id":"T77","span":{"begin":653,"end":661},"obj":"Chemical"}],"attributes":[{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":164,"end":167},"obj":"GlycoEpitope"},{"id":"T2","span":{"begin":191,"end":194},"obj":"GlycoEpitope"},{"id":"T3","span":{"begin":201,"end":204},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/AN0057"},{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/AN0611"},{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/AN0206"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"LitCovid-sentences","denotations":[{"id":"T107","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T108","span":{"begin":142,"end":320},"obj":"Sentence"},{"id":"T109","span":{"begin":321,"end":459},"obj":"Sentence"},{"id":"T110","span":{"begin":460,"end":565},"obj":"Sentence"},{"id":"T111","span":{"begin":566,"end":730},"obj":"Sentence"},{"id":"T112","span":{"begin":731,"end":817},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}

{"project":"2_test","denotations":[{"id":"32450171-19748648-66454463","span":{"begin":159,"end":161},"obj":"19748648"},{"id":"32450171-15313178-66454464","span":{"begin":561,"end":563},"obj":"15313178"},{"id":"32450171-19748648-66454465","span":{"begin":723,"end":725},"obj":"19748648"},{"id":"32450171-17161858-66454466","span":{"begin":726,"end":728},"obj":"17161858"}],"text":"By using Xenomouse in which mouse immunoglobulin genes were replaced by human immunoglobulin genes, 19 neutralizing mAbs bound S1 were found. 18 of them, 1B5 [38], 3A7, 3C7, 3F3, 3H12, 4A10, 4E2, 4G2, 5A5, 5A7, 5D3, 5D6, 5E4, 6B1, 6B5, 6B8, 6C1 and 6C2 bound RBD (aa 318–510) to avoid virus binding to the ACE2 receptor. The last one, 4D4, bound an epitope (aa 12–261) located on the N-terminal of RBD and inhibited post-binding event but not the RBD binding. Truncation of the first 300 amino acids of S1 blocked the trimerization and the fusion of S protein [39]. Synergistic effects in some SARS-CoV strains of 4D4 with other mAbs targeting S1 or S2 proteins such as 3C7 (S1), 1F8 (HR1) or 5E9 (HR2) were also reported [38,40]. The tri-combination of 3C7, 3H12 and 4D4 could effectively neutralize escape variants."}