PMC:7243768 / 66219-67167 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"Currently, hrsACE2 has been approved as a treatment option of ARDS. African green monkey kidney derived cell line; namely, Vero E6 was cultured and infected with SARS-CoV-2. Then the infected culture was added with hrsACE2 to estimate the therapeutic potential of hrsACE2. 15 h post-infection, the viral replication was found to be inhibited in a dose-dependent manner with reference to the concentration of hrsACE2 added. The addition of hrsACE2 to the embryonic stem cells derived kidney organoids comprised of proximal tubular cells and podocytes clusters infected with SARS-CoV-2 had shown to reduce the viral replication in a dose-dependent manner. No studies support the in-vivo and the therapeutic roles of hrsACE2 on the pulmonary cells upon SARS-CoV-2 infection [153,155]. Therefore, the usage of hrsACE2 can be a potential therapeutic option to inhibit the viral infection besides preserving the ACE2 levels and blood pressure in control.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"2593","span":{"begin":906,"end":910},"obj":"Gene"},{"id":"2594","span":{"begin":68,"end":88},"obj":"Species"},{"id":"2595","span":{"begin":162,"end":172},"obj":"Species"},{"id":"2596","span":{"begin":573,"end":583},"obj":"Species"},{"id":"2597","span":{"begin":62,"end":66},"obj":"Disease"},{"id":"2598","span":{"begin":148,"end":156},"obj":"Disease"},{"id":"2599","span":{"begin":183,"end":191},"obj":"Disease"},{"id":"2600","span":{"begin":283,"end":292},"obj":"Disease"},{"id":"2601","span":{"begin":559,"end":567},"obj":"Disease"},{"id":"2602","span":{"begin":755,"end":770},"obj":"Disease"},{"id":"2603","span":{"begin":867,"end":882},"obj":"Disease"}],"attributes":[{"id":"A2593","pred":"tao:has_database_id","subj":"2593","obj":"Gene:59272"},{"id":"A2594","pred":"tao:has_database_id","subj":"2594","obj":"Tax:9534"},{"id":"A2595","pred":"tao:has_database_id","subj":"2595","obj":"Tax:2697049"},{"id":"A2596","pred":"tao:has_database_id","subj":"2596","obj":"Tax:2697049"},{"id":"A2597","pred":"tao:has_database_id","subj":"2597","obj":"MESH:D012128"},{"id":"A2598","pred":"tao:has_database_id","subj":"2598","obj":"MESH:D007239"},{"id":"A2599","pred":"tao:has_database_id","subj":"2599","obj":"MESH:D007239"},{"id":"A2600","pred":"tao:has_database_id","subj":"2600","obj":"MESH:D007239"},{"id":"A2601","pred":"tao:has_database_id","subj":"2601","obj":"MESH:D007239"},{"id":"A2602","pred":"tao:has_database_id","subj":"2602","obj":"MESH:C000657245"},{"id":"A2603","pred":"tao:has_database_id","subj":"2603","obj":"MESH:D001102"},{"subj":"2593","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2594","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2595","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2596","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2597","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2598","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2599","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2600","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2601","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2602","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2603","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T536","span":{"begin":89,"end":95},"obj":"Body_part"},{"id":"T537","span":{"begin":104,"end":108},"obj":"Body_part"},{"id":"T538","span":{"begin":454,"end":474},"obj":"Body_part"},{"id":"T539","span":{"begin":469,"end":474},"obj":"Body_part"},{"id":"T540","span":{"begin":483,"end":489},"obj":"Body_part"},{"id":"T541","span":{"begin":530,"end":535},"obj":"Body_part"},{"id":"T542","span":{"begin":739,"end":744},"obj":"Body_part"},{"id":"T543","span":{"begin":922,"end":927},"obj":"Body_part"}],"attributes":[{"id":"A536","pred":"fma_id","subj":"T536","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A537","pred":"fma_id","subj":"T537","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A538","pred":"fma_id","subj":"T538","obj":"http://purl.org/sig/ont/fma/fma82841"},{"id":"A539","pred":"fma_id","subj":"T539","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A540","pred":"fma_id","subj":"T540","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A541","pred":"fma_id","subj":"T541","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A542","pred":"fma_id","subj":"T542","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A543","pred":"fma_id","subj":"T543","obj":"http://purl.org/sig/ont/fma/fma9670"},{"subj":"T536","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T537","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T538","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T539","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T540","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T541","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T542","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T543","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T264","span":{"begin":89,"end":95},"obj":"Body_part"},{"id":"T265","span":{"begin":483,"end":489},"obj":"Body_part"},{"id":"T266","span":{"begin":922,"end":927},"obj":"Body_part"}],"attributes":[{"id":"A264","pred":"uberon_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A265","pred":"uberon_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A266","pred":"uberon_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T789","span":{"begin":62,"end":66},"obj":"Disease"},{"id":"T790","span":{"begin":162,"end":170},"obj":"Disease"},{"id":"T791","span":{"begin":162,"end":166},"obj":"Disease"},{"id":"T792","span":{"begin":283,"end":303},"obj":"Disease"},{"id":"T793","span":{"begin":283,"end":292},"obj":"Disease"},{"id":"T794","span":{"begin":573,"end":581},"obj":"Disease"},{"id":"T795","span":{"begin":573,"end":577},"obj":"Disease"},{"id":"T796","span":{"begin":750,"end":758},"obj":"Disease"},{"id":"T797","span":{"begin":750,"end":754},"obj":"Disease"},{"id":"T798","span":{"begin":761,"end":770},"obj":"Disease"},{"id":"T799","span":{"begin":867,"end":882},"obj":"Disease"},{"id":"T800","span":{"begin":873,"end":882},"obj":"Disease"}],"attributes":[{"id":"A789","pred":"mondo_id","subj":"T789","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A790","pred":"mondo_id","subj":"T790","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A791","pred":"mondo_id","subj":"T791","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A792","pred":"mondo_id","subj":"T792","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A793","pred":"mondo_id","subj":"T793","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A794","pred":"mondo_id","subj":"T794","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A795","pred":"mondo_id","subj":"T795","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A796","pred":"mondo_id","subj":"T796","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A797","pred":"mondo_id","subj":"T797","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A798","pred":"mondo_id","subj":"T798","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A799","pred":"mondo_id","subj":"T799","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A800","pred":"mondo_id","subj":"T800","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T789","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T790","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T791","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T792","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T793","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T794","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T795","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T796","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T797","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T798","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T799","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T800","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T818","span":{"begin":19,"end":22},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T819","span":{"begin":40,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T820","span":{"begin":82,"end":88},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9479"},{"id":"T821","span":{"begin":89,"end":95},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T822","span":{"begin":89,"end":95},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T823","span":{"begin":89,"end":95},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T824","span":{"begin":104,"end":113},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T825","span":{"begin":123,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T826","span":{"begin":123,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T827","span":{"begin":345,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T828","span":{"begin":464,"end":474},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T829","span":{"begin":483,"end":489},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T830","span":{"begin":483,"end":489},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T831","span":{"begin":483,"end":489},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T832","span":{"begin":530,"end":535},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T833","span":{"begin":629,"end":630},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T834","span":{"begin":739,"end":744},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T835","span":{"begin":821,"end":822},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T836","span":{"begin":922,"end":927},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T837","span":{"begin":922,"end":927},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"}],"attributes":[{"subj":"T818","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T819","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T820","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T821","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T822","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T823","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T824","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T825","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T826","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T827","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T828","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T829","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T830","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T831","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T832","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T833","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T834","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T835","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T836","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T837","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T142","span":{"begin":298,"end":315},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T143","span":{"begin":298,"end":315},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T144","span":{"begin":608,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T145","span":{"begin":608,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T146","span":{"begin":867,"end":882},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"attributes":[{"subj":"T142","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T489","span":{"begin":0,"end":67},"obj":"Sentence"},{"id":"T490","span":{"begin":68,"end":173},"obj":"Sentence"},{"id":"T491","span":{"begin":174,"end":272},"obj":"Sentence"},{"id":"T492","span":{"begin":273,"end":422},"obj":"Sentence"},{"id":"T493","span":{"begin":423,"end":653},"obj":"Sentence"},{"id":"T494","span":{"begin":654,"end":781},"obj":"Sentence"},{"id":"T495","span":{"begin":782,"end":948},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T489","pred":"source","obj":"LitCovid-sentences"},{"subj":"T490","pred":"source","obj":"LitCovid-sentences"},{"subj":"T491","pred":"source","obj":"LitCovid-sentences"},{"subj":"T492","pred":"source","obj":"LitCovid-sentences"},{"subj":"T493","pred":"source","obj":"LitCovid-sentences"},{"subj":"T494","pred":"source","obj":"LitCovid-sentences"},{"subj":"T495","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32450165-32354636-66451129","span":{"begin":772,"end":775},"obj":"32354636"},{"id":"32450165-17482553-66451130","span":{"begin":776,"end":779},"obj":"17482553"}],"attributes":[{"subj":"32450165-32354636-66451129","pred":"source","obj":"2_test"},{"subj":"32450165-17482553-66451130","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93c3ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ddec93"},{"id":"LitCovid-PD-UBERON","color":"#e193ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecc7"},{"id":"LitCovid-PD-CLO","color":"#ecad93"},{"id":"LitCovid-PD-GO-BP","color":"#9393ec"},{"id":"LitCovid-sentences","color":"#adec93"},{"id":"2_test","color":"#ec93c7"}]}]}}