PMC:7243768 / 66219-67167 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
2593	906-910	Gene	denotes	ACE2	Gene:59272
2594	68-88	Species	denotes	African green monkey	Tax:9534
2595	162-172	Species	denotes	SARS-CoV-2	Tax:2697049
2596	573-583	Species	denotes	SARS-CoV-2	Tax:2697049
2597	62-66	Disease	denotes	ARDS	MESH:D012128
2598	148-156	Disease	denotes	infected	MESH:D007239
2599	183-191	Disease	denotes	infected	MESH:D007239
2600	283-292	Disease	denotes	infection	MESH:D007239
2601	559-567	Disease	denotes	infected	MESH:D007239
2602	755-770	Disease	denotes	CoV-2 infection	MESH:C000657245
2603	867-882	Disease	denotes	viral infection	MESH:D001102

Id	Subject	Object	Predicate	Lexical cue	fma_id
T536	89-95	Body_part	denotes	kidney	http://purl.org/sig/ont/fma/fma7203
T537	104-108	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T538	454-474	Body_part	denotes	embryonic stem cells	http://purl.org/sig/ont/fma/fma82841
T539	469-474	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T540	483-489	Body_part	denotes	kidney	http://purl.org/sig/ont/fma/fma7203
T541	530-535	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T542	739-744	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T543	922-927	Body_part	denotes	blood	http://purl.org/sig/ont/fma/fma9670

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T264	89-95	Body_part	denotes	kidney	http://purl.obolibrary.org/obo/UBERON_0002113
T265	483-489	Body_part	denotes	kidney	http://purl.obolibrary.org/obo/UBERON_0002113
T266	922-927	Body_part	denotes	blood	http://purl.obolibrary.org/obo/UBERON_0000178

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T789	62-66	Disease	denotes	ARDS	http://purl.obolibrary.org/obo/MONDO_0006502
T790	162-170	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T791	162-166	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T792	283-303	Disease	denotes	infection, the viral	http://purl.obolibrary.org/obo/MONDO_0005108
T793	283-292	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T794	573-581	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T795	573-577	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T796	750-758	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T797	750-754	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091
T798	761-770	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550
T799	867-882	Disease	denotes	viral infection	http://purl.obolibrary.org/obo/MONDO_0005108
T800	873-882	Disease	denotes	infection	http://purl.obolibrary.org/obo/MONDO_0005550

Id	Subject	Object	Predicate	Lexical cue
T818	19-22	http://purl.obolibrary.org/obo/CLO_0051582	denotes	has
T819	40-41	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T820	82-88	http://purl.obolibrary.org/obo/NCBITaxon_9479	denotes	monkey
T821	89-95	http://purl.obolibrary.org/obo/UBERON_0002113	denotes	kidney
T822	89-95	http://www.ebi.ac.uk/efo/EFO_0000927	denotes	kidney
T823	89-95	http://www.ebi.ac.uk/efo/EFO_0000929	denotes	kidney
T824	104-113	http://purl.obolibrary.org/obo/CLO_0000031	denotes	cell line
T825	123-127	http://purl.obolibrary.org/obo/CLO_0009524	denotes	Vero
T826	123-127	http://purl.obolibrary.org/obo/CLO_0050515	denotes	Vero
T827	345-346	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T828	464-474	http://purl.obolibrary.org/obo/CL_0000034	denotes	stem cells
T829	483-489	http://purl.obolibrary.org/obo/UBERON_0002113	denotes	kidney
T830	483-489	http://www.ebi.ac.uk/efo/EFO_0000927	denotes	kidney
T831	483-489	http://www.ebi.ac.uk/efo/EFO_0000929	denotes	kidney
T832	530-535	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T833	629-630	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T834	739-744	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T835	821-822	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T836	922-927	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T837	922-927	http://www.ebi.ac.uk/efo/EFO_0000296	denotes	blood

Id	Subject	Object	Predicate	Lexical cue
T142	298-315	http://purl.obolibrary.org/obo/GO_0019079	denotes	viral replication
T143	298-315	http://purl.obolibrary.org/obo/GO_0019058	denotes	viral replication
T144	608-625	http://purl.obolibrary.org/obo/GO_0019079	denotes	viral replication
T145	608-625	http://purl.obolibrary.org/obo/GO_0019058	denotes	viral replication
T146	867-882	http://purl.obolibrary.org/obo/GO_0016032	denotes	viral infection

Id	Subject	Object	Predicate	Lexical cue
T489	0-67	Sentence	denotes	Currently, hrsACE2 has been approved as a treatment option of ARDS.
T490	68-173	Sentence	denotes	African green monkey kidney derived cell line; namely, Vero E6 was cultured and infected with SARS-CoV-2.
T491	174-272	Sentence	denotes	Then the infected culture was added with hrsACE2 to estimate the therapeutic potential of hrsACE2.
T492	273-422	Sentence	denotes	15 h post-infection, the viral replication was found to be inhibited in a dose-dependent manner with reference to the concentration of hrsACE2 added.
T493	423-653	Sentence	denotes	The addition of hrsACE2 to the embryonic stem cells derived kidney organoids comprised of proximal tubular cells and podocytes clusters infected with SARS-CoV-2 had shown to reduce the viral replication in a dose-dependent manner.
T494	654-781	Sentence	denotes	No studies support the in-vivo and the therapeutic roles of hrsACE2 on the pulmonary cells upon SARS-CoV-2 infection [153,155].
T495	782-948	Sentence	denotes	Therefore, the usage of hrsACE2 can be a potential therapeutic option to inhibit the viral infection besides preserving the ACE2 levels and blood pressure in control.

Id	Subject	Object	Predicate	Lexical cue
32450165-32354636-66451129	772-775	32354636	denotes	153
32450165-17482553-66451130	776-779	17482553	denotes	155