PMC:7243768 / 26642-27312 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"5.5 MERS-CoV-immunopathology\nLike the SARS-CoV, MERS also has an infection in the airway epithelial cells, which enhances the level of pro-inflammatory cytokines and IFN in a delayed manner [81]. Even in the cells of THP-1, macrophage-derived from the human peripheral blood, dendritic cells showed an elevated level of the chemokines such as CCL3, CCL2, IL-2, IL-8, and CCL-5 and pro-inflammatory cytokines in a delayed manner during MERS-CoV infection [82,83]. The high level of the pro-inflammatory cytokine and chemokine associated with the enhanced level of the monocyte, neutrophil numbers in both the lung and peripheral blood, which leads to immune damage [84].","divisions":[{"label":"label","span":{"begin":0,"end":3}},{"label":"title","span":{"begin":5,"end":29}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1029","span":{"begin":5,"end":13},"obj":"Species"},{"id":"1041","span":{"begin":167,"end":170},"obj":"Gene"},{"id":"1042","span":{"begin":218,"end":223},"obj":"Gene"},{"id":"1043","span":{"begin":344,"end":348},"obj":"Gene"},{"id":"1044","span":{"begin":350,"end":354},"obj":"Gene"},{"id":"1045","span":{"begin":356,"end":360},"obj":"Gene"},{"id":"1046","span":{"begin":362,"end":366},"obj":"Gene"},{"id":"1047","span":{"begin":372,"end":377},"obj":"Gene"},{"id":"1048","span":{"begin":39,"end":47},"obj":"Species"},{"id":"1049","span":{"begin":253,"end":258},"obj":"Species"},{"id":"1050","span":{"begin":66,"end":75},"obj":"Disease"},{"id":"1051","span":{"begin":436,"end":454},"obj":"Disease"}],"attributes":[{"id":"A1029","pred":"tao:has_database_id","subj":"1029","obj":"Tax:1335626"},{"id":"A1041","pred":"tao:has_database_id","subj":"1041","obj":"Gene:3439"},{"id":"A1042","pred":"tao:has_database_id","subj":"1042","obj":"Gene:2736"},{"id":"A1043","pred":"tao:has_database_id","subj":"1043","obj":"Gene:6348"},{"id":"A1044","pred":"tao:has_database_id","subj":"1044","obj":"Gene:6347"},{"id":"A1045","pred":"tao:has_database_id","subj":"1045","obj":"Gene:3558"},{"id":"A1046","pred":"tao:has_database_id","subj":"1046","obj":"Gene:3576"},{"id":"A1047","pred":"tao:has_database_id","subj":"1047","obj":"Gene:6352"},{"id":"A1048","pred":"tao:has_database_id","subj":"1048","obj":"Tax:694009"},{"id":"A1049","pred":"tao:has_database_id","subj":"1049","obj":"Tax:9606"},{"id":"A1050","pred":"tao:has_database_id","subj":"1050","obj":"MESH:D007239"},{"id":"A1051","pred":"tao:has_database_id","subj":"1051","obj":"MESH:D018352"},{"subj":"1029","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1041","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1042","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1043","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1044","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1045","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1046","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1047","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1048","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1049","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1050","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1051","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T239","span":{"begin":90,"end":106},"obj":"Body_part"},{"id":"T240","span":{"begin":101,"end":106},"obj":"Body_part"},{"id":"T241","span":{"begin":153,"end":162},"obj":"Body_part"},{"id":"T242","span":{"begin":209,"end":214},"obj":"Body_part"},{"id":"T243","span":{"begin":225,"end":235},"obj":"Body_part"},{"id":"T244","span":{"begin":270,"end":275},"obj":"Body_part"},{"id":"T245","span":{"begin":277,"end":292},"obj":"Body_part"},{"id":"T246","span":{"begin":287,"end":292},"obj":"Body_part"},{"id":"T247","span":{"begin":325,"end":335},"obj":"Body_part"},{"id":"T248","span":{"begin":356,"end":360},"obj":"Body_part"},{"id":"T249","span":{"begin":399,"end":408},"obj":"Body_part"},{"id":"T250","span":{"begin":503,"end":511},"obj":"Body_part"},{"id":"T251","span":{"begin":516,"end":525},"obj":"Body_part"},{"id":"T252","span":{"begin":568,"end":576},"obj":"Body_part"},{"id":"T253","span":{"begin":578,"end":588},"obj":"Body_part"},{"id":"T254","span":{"begin":609,"end":613},"obj":"Body_part"},{"id":"T255","span":{"begin":629,"end":634},"obj":"Body_part"}],"attributes":[{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A248","pred":"fma_id","subj":"T248","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A249","pred":"fma_id","subj":"T249","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A250","pred":"fma_id","subj":"T250","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A251","pred":"fma_id","subj":"T251","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A252","pred":"fma_id","subj":"T252","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A253","pred":"fma_id","subj":"T253","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma9670"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T122","span":{"begin":270,"end":275},"obj":"Body_part"},{"id":"T123","span":{"begin":609,"end":613},"obj":"Body_part"},{"id":"T124","span":{"begin":629,"end":634},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"uberon_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A123","pred":"uberon_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A124","pred":"uberon_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T308","span":{"begin":39,"end":47},"obj":"Disease"},{"id":"T309","span":{"begin":39,"end":43},"obj":"Disease"},{"id":"T310","span":{"begin":66,"end":75},"obj":"Disease"},{"id":"T311","span":{"begin":445,"end":454},"obj":"Disease"}],"attributes":[{"id":"A308","pred":"mondo_id","subj":"T308","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A309","pred":"mondo_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A310","pred":"mondo_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A311","pred":"mondo_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T309","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T310","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T311","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T358","span":{"begin":59,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T359","span":{"begin":83,"end":89},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T360","span":{"begin":90,"end":100},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T361","span":{"begin":101,"end":106},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T362","span":{"begin":174,"end":175},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T363","span":{"begin":209,"end":214},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T364","span":{"begin":218,"end":223},"obj":"http://purl.obolibrary.org/obo/CLO_0009348"},{"id":"T365","span":{"begin":218,"end":223},"obj":"http://purl.obolibrary.org/obo/CLO_0050999"},{"id":"T366","span":{"begin":218,"end":223},"obj":"http://purl.obolibrary.org/obo/CLO_0051914"},{"id":"T367","span":{"begin":253,"end":258},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T368","span":{"begin":270,"end":275},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T369","span":{"begin":270,"end":275},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T370","span":{"begin":277,"end":292},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T371","span":{"begin":356,"end":360},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T372","span":{"begin":362,"end":366},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T373","span":{"begin":412,"end":413},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T374","span":{"begin":568,"end":576},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T375","span":{"begin":609,"end":613},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T376","span":{"begin":609,"end":613},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T377","span":{"begin":629,"end":634},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T378","span":{"begin":629,"end":634},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"}],"attributes":[{"subj":"T358","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T359","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T360","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T361","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T362","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T363","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T364","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T365","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T366","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T367","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T368","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T369","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T370","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T374","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T375","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T376","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T377","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T378","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T114","span":{"begin":218,"end":221},"obj":"Chemical"},{"id":"T115","span":{"begin":356,"end":358},"obj":"Chemical"},{"id":"T117","span":{"begin":362,"end":364},"obj":"Chemical"},{"id":"T119","span":{"begin":372,"end":375},"obj":"Chemical"}],"attributes":[{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_46941"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A116","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A118","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T180","span":{"begin":0,"end":29},"obj":"Sentence"},{"id":"T181","span":{"begin":30,"end":196},"obj":"Sentence"},{"id":"T182","span":{"begin":197,"end":463},"obj":"Sentence"},{"id":"T183","span":{"begin":464,"end":670},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T180","pred":"source","obj":"LitCovid-sentences"},{"subj":"T181","pred":"source","obj":"LitCovid-sentences"},{"subj":"T182","pred":"source","obj":"LitCovid-sentences"},{"subj":"T183","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32450165-24077366-66451069","span":{"begin":192,"end":194},"obj":"24077366"},{"id":"32450165-26602089-66451070","span":{"begin":456,"end":458},"obj":"26602089"},{"id":"32450165-24065148-66451071","span":{"begin":459,"end":461},"obj":"24065148"},{"id":"32450165-27709848-66451072","span":{"begin":666,"end":668},"obj":"27709848"}],"attributes":[{"subj":"32450165-24077366-66451069","pred":"source","obj":"2_test"},{"subj":"32450165-26602089-66451070","pred":"source","obj":"2_test"},{"subj":"32450165-24065148-66451071","pred":"source","obj":"2_test"},{"subj":"32450165-27709848-66451072","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ece5","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ecca93"},{"id":"LitCovid-PD-UBERON","color":"#b093ec"},{"id":"LitCovid-PD-MONDO","color":"#93ec96"},{"id":"LitCovid-PD-CLO","color":"#ec93a9"},{"id":"LitCovid-PD-CHEBI","color":"#93c3ec"},{"id":"LitCovid-sentences","color":"#ddec93"},{"id":"2_test","color":"#e193ec"}]}]}}