PMC:7228307 / 5747-7512
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
84 | 141-149 | Gene | denotes | FcγRIIIa | Gene:2214 |
85 | 304-312 | Gene | denotes | FcγRIIIa | Gene:2214 |
86 | 532-539 | Gene | denotes | FcγRIIb | Gene:2213 |
87 | 833-840 | Gene | denotes | FcγRIIb | Gene:2213 |
88 | 1274-1281 | Gene | denotes | FcγRIIb | Gene:2213 |
89 | 664-668 | Gene | denotes | FcγR | Gene:2213 |
90 | 291-295 | Gene | denotes | FcγR | Gene:2213 |
91 | 42-46 | Gene | denotes | FcγR | Gene:2213 |
92 | 1387-1391 | Gene | denotes | FcγR | Gene:2213 |
93 | 879-886 | Gene | denotes | FcγRIIb | Gene:2213 |
94 | 1704-1707 | Gene | denotes | BCR | Gene:613 |
95 | 317-324 | Gene | denotes | FcγRIIa | Gene:2212 |
96 | 560-568 | Chemical | denotes | tyrosine | MESH:D014443 |
97 | 902-910 | Chemical | denotes | tyrosine | MESH:D014443 |
98 | 1002-1006 | Chemical | denotes | ITAM | |
99 | 124-136 | Disease | denotes | cytotoxicity | MESH:D064420 |
100 | 1163-1166 | Disease | denotes | APC | MESH:D011125 |
101 | 1677-1689 | Disease | denotes | cytotoxicity | MESH:D064420 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T35 | 71-90 | Body_part | denotes | Natural killer cell | http://purl.org/sig/ont/fma/fma63147 |
T36 | 86-90 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T37 | 91-99 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T38 | 110-114 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T39 | 155-163 | Body_part | denotes | Antibody | http://purl.org/sig/ont/fma/fma62871 |
T40 | 174-178 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T41 | 462-486 | Body_part | denotes | antigen‐presenting cells | http://purl.org/sig/ont/fma/fma273565 |
T42 | 481-486 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T43 | 513-517 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T44 | 560-568 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
T45 | 617-621 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T46 | 694-699 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T47 | 708-719 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T48 | 724-733 | Body_part | denotes | basophils | http://purl.org/sig/ont/fma/fma62862 |
T49 | 750-753 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T50 | 902-910 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
T51 | 1056-1060 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T52 | 1322-1326 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T53 | 1371-1379 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T54 | 1399-1403 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T55 | 1448-1452 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T56 | 1530-1535 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T57 | 1562-1571 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T58 | 1622-1630 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T59 | 1644-1652 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T60 | 1663-1667 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T61 | 1691-1693 | Body_part | denotes | Ag | http://purl.org/sig/ont/fma/fma61898 |
T62 | 1711-1715 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T63 | 1726-1728 | Body_part | denotes | Ig | http://purl.org/sig/ont/fma/fma62871 |
T64 | 1730-1744 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T19 | 1638-1642 | Disease | denotes | ADCC | http://purl.obolibrary.org/obo/MONDO_0008734 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T72 | 42-44 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T73 | 68-69 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T74 | 71-90 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | Natural killer cell |
T75 | 110-114 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T76 | 141-143 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T77 | 152-153 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T78 | 174-178 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T79 | 265-275 | http://purl.obolibrary.org/obo/CL_0000234 | denotes | phagocytes |
T80 | 280-290 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
T81 | 291-293 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T82 | 304-306 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T83 | 317-319 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T84 | 481-486 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T85 | 513-517 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T86 | 518-528 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T87 | 532-534 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T88 | 569-579 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T89 | 602-611 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
T90 | 615-621 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B‐cell |
T91 | 653-663 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
T92 | 664-666 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T93 | 694-699 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T94 | 754-756 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T95 | 792-802 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
T96 | 833-835 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T97 | 879-881 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T98 | 1014-1023 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
T99 | 1056-1060 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T100 | 1227-1229 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T101 | 1230-1232 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | Rs |
T102 | 1238-1239 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T103 | 1274-1276 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T104 | 1286-1292 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T105 | 1322-1326 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T106 | 1387-1389 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
T107 | 1399-1403 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T108 | 1414-1415 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T109 | 1416-1422 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T110 | 1448-1452 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T111 | 1493-1503 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T112 | 1530-1535 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T113 | 1576-1583 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | extreme |
T114 | 1663-1667 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T115 | 1709-1715 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B‐cell |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T18 | 47-55 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
T19 | 416-423 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T20 | 429-436 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T21 | 462-469 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T22 | 560-568 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
T23 | 622-629 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T24 | 902-910 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
T25 | 1163-1166 | Chemical | denotes | APC | http://purl.obolibrary.org/obo/CHEBI_80551 |
T26 | 1313-1321 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
T27 | 1691-1693 | Chemical | denotes | Ag | http://purl.obolibrary.org/obo/CHEBI_30512|http://purl.obolibrary.org/obo/CHEBI_9141 |
T29 | 1695-1702 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-sample-MedDRA
Id | Subject | Object | Predicate | Lexical cue | meddra_id |
---|---|---|---|---|---|
T8 | 1726-1728 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | Ig | http://purl.bioontology.org/ontology/MEDDRA/10021496 |
T9 | 1730-1744 | http://purl.bioontology.org/ontology/MEDDRA/10022891 | denotes | immunoglobulin | http://purl.bioontology.org/ontology/MEDDRA/10021496 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T30 | 56-65 | http://purl.obolibrary.org/obo/BFO_0000034 | denotes | functions |
T31 | 86-90 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T32 | 110-114 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T33 | 174-178 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T34 | 481-486 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T35 | 513-517 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T36 | 617-621 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T37 | 694-699 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T38 | 1056-1060 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T39 | 1180-1196 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T40 | 1322-1326 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T41 | 1399-1403 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T42 | 1448-1452 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T43 | 1530-1535 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T44 | 1663-1667 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
T45 | 1711-1715 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T4 | 560-568 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
T5 | 902-910 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
100 | 1163-1166 | Disease | denotes | APC | MESH:D011125 |
101 | 1677-1689 | Disease | denotes | cytotoxicity | MESH:D064420 |
84 | 141-149 | Gene | denotes | FcγRIIIa | Gene:2214 |
85 | 304-312 | Gene | denotes | FcγRIIIa | Gene:2214 |
86 | 532-539 | Gene | denotes | FcγRIIb | Gene:2213 |
87 | 833-840 | Gene | denotes | FcγRIIb | Gene:2213 |
88 | 1274-1281 | Gene | denotes | FcγRIIb | Gene:2213 |
89 | 664-668 | Gene | denotes | FcγR | Gene:2213 |
90 | 291-295 | Gene | denotes | FcγR | Gene:2213 |
91 | 42-46 | Gene | denotes | FcγR | Gene:2213 |
92 | 1387-1391 | Gene | denotes | FcγR | Gene:2213 |
93 | 879-886 | Gene | denotes | FcγRIIb | Gene:2213 |
94 | 1704-1707 | Gene | denotes | BCR | Gene:613 |
95 | 317-324 | Gene | denotes | FcγRIIa | Gene:2212 |
96 | 560-568 | Chemical | denotes | tyrosine | MESH:D014443 |
97 | 902-910 | Chemical | denotes | tyrosine | MESH:D014443 |
98 | 1002-1006 | Chemical | denotes | ITAM | |
99 | 124-136 | Disease | denotes | cytotoxicity | MESH:D064420 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T30 | 0-325 | Sentence | denotes | Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. |
T31 | 326-540 | Sentence | denotes | Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. |
T32 | 541-841 | Sentence | denotes | The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. |
T33 | 842-1253 | Sentence | denotes | This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. |
T34 | 1254-1572 | Sentence | denotes | Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. |
T35 | 1573-1637 | Sentence | denotes | In extreme cases, this leads to life‐threatening cytokine storm. |
T36 | 1638-1765 | Sentence | denotes | ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer. |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T1 | 1163-1166 | Protein | denotes | APC | https://www.uniprot.org/uniprot/P0C1F2|https://www.uniprot.org/uniprot/P01532 |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T35 | 71-90 | Body_part | denotes | Natural killer cell | http://purl.org/sig/ont/fma/fma63147 |
T36 | 86-90 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T37 | 91-99 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T38 | 110-114 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T39 | 155-163 | Body_part | denotes | Antibody | http://purl.org/sig/ont/fma/fma62871 |
T40 | 174-178 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T41 | 462-486 | Body_part | denotes | antigen‐presenting cells | http://purl.org/sig/ont/fma/fma273565 |
T42 | 481-486 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T43 | 513-517 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T44 | 560-568 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
T45 | 617-621 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T46 | 694-699 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T47 | 708-719 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T48 | 724-733 | Body_part | denotes | basophils | http://purl.org/sig/ont/fma/fma62862 |
T49 | 750-753 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T50 | 902-910 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
T51 | 1056-1060 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T52 | 1322-1326 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T53 | 1371-1379 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T54 | 1399-1403 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T55 | 1448-1452 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T56 | 1530-1535 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T57 | 1562-1571 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T58 | 1622-1630 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T59 | 1644-1652 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T60 | 1663-1667 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T61 | 1711-1715 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T62 | 1726-1728 | Body_part | denotes | Ig | http://purl.org/sig/ont/fma/fma62871 |
T63 | 1730-1744 | Body_part | denotes | immunoglobulin | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12 | 188-200 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
T13 | 429-449 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen‐presentation |
T14 | 499-528 | http://purl.obolibrary.org/obo/GO_0050866 | denotes | Inhibition of cell activation |
T15 | 513-528 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
T16 | 602-611 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T17 | 680-693 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
T18 | 856-871 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T19 | 971-983 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatases |
T20 | 1014-1023 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T21 | 1180-1196 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T22 | 1467-1489 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | induction of apoptosis |
T23 | 1480-1489 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T24 | 1549-1558 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T25 | 1638-1642 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
LitCovid-sample-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T4 | 1622-1636 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12 | 188-200 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
T13 | 429-449 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen‐presentation |
T14 | 499-528 | http://purl.obolibrary.org/obo/GO_0050866 | denotes | Inhibition of cell activation |
T15 | 513-528 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
T16 | 602-611 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T17 | 680-693 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
T18 | 856-871 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T19 | 971-983 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatases |
T20 | 1014-1023 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T21 | 1180-1196 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T22 | 1467-1489 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | induction of apoptosis |
T23 | 1480-1489 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T24 | 1549-1558 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T25 | 1638-1642 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12 | 188-200 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
T13 | 429-449 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen‐presentation |
T14 | 499-528 | http://purl.obolibrary.org/obo/GO_0050866 | denotes | Inhibition of cell activation |
T15 | 513-528 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
T16 | 602-611 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T17 | 680-693 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
T18 | 856-871 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T19 | 971-983 | http://purl.obolibrary.org/obo/GO_0016791 | denotes | phosphatases |
T20 | 1014-1023 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T21 | 1180-1196 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T22 | 1467-1489 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | induction of apoptosis |
T23 | 1480-1489 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T24 | 1549-1558 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T25 | 1638-1642 | http://purl.obolibrary.org/obo/GO_0001788 | denotes | ADCC |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T30 | 0-325 | Sentence | denotes | Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. |
T31 | 326-540 | Sentence | denotes | Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. |
T32 | 541-841 | Sentence | denotes | The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. |
T33 | 842-1253 | Sentence | denotes | This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. |
T34 | 1254-1572 | Sentence | denotes | Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. |
T35 | 1573-1637 | Sentence | denotes | In extreme cases, this leads to life‐threatening cytokine storm. |
T36 | 1638-1765 | Sentence | denotes | ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T4 | 1622-1636 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |