PMC:7228307 / 5747-7512 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"84","span":{"begin":141,"end":149},"obj":"Gene"},{"id":"85","span":{"begin":304,"end":312},"obj":"Gene"},{"id":"86","span":{"begin":532,"end":539},"obj":"Gene"},{"id":"87","span":{"begin":833,"end":840},"obj":"Gene"},{"id":"88","span":{"begin":1274,"end":1281},"obj":"Gene"},{"id":"89","span":{"begin":664,"end":668},"obj":"Gene"},{"id":"90","span":{"begin":291,"end":295},"obj":"Gene"},{"id":"91","span":{"begin":42,"end":46},"obj":"Gene"},{"id":"92","span":{"begin":1387,"end":1391},"obj":"Gene"},{"id":"93","span":{"begin":879,"end":886},"obj":"Gene"},{"id":"94","span":{"begin":1704,"end":1707},"obj":"Gene"},{"id":"95","span":{"begin":317,"end":324},"obj":"Gene"},{"id":"96","span":{"begin":560,"end":568},"obj":"Chemical"},{"id":"97","span":{"begin":902,"end":910},"obj":"Chemical"},{"id":"98","span":{"begin":1002,"end":1006},"obj":"Chemical"},{"id":"99","span":{"begin":124,"end":136},"obj":"Disease"},{"id":"100","span":{"begin":1163,"end":1166},"obj":"Disease"},{"id":"101","span":{"begin":1677,"end":1689},"obj":"Disease"}],"attributes":[{"id":"A84","pred":"tao:has_database_id","subj":"84","obj":"Gene:2214"},{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"Gene:2214"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"Gene:2213"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Gene:2213"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Gene:2213"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Gene:2213"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"Gene:2213"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"Gene:2213"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"Gene:2213"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"Gene:2213"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"Gene:613"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"Gene:2212"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"MESH:D014443"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:D014443"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D064420"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"MESH:D011125"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

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(a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T19","span":{"begin":1638,"end":1642},"obj":"Disease"}],"attributes":[{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0008734"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

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(a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T18","span":{"begin":47,"end":55},"obj":"Chemical"},{"id":"T19","span":{"begin":416,"end":423},"obj":"Chemical"},{"id":"T20","span":{"begin":429,"end":436},"obj":"Chemical"},{"id":"T21","span":{"begin":462,"end":469},"obj":"Chemical"},{"id":"T22","span":{"begin":560,"end":568},"obj":"Chemical"},{"id":"T23","span":{"begin":622,"end":629},"obj":"Chemical"},{"id":"T24","span":{"begin":902,"end":910},"obj":"Chemical"},{"id":"T25","span":{"begin":1163,"end":1166},"obj":"Chemical"},{"id":"T26","span":{"begin":1313,"end":1321},"obj":"Chemical"},{"id":"T27","span":{"begin":1691,"end":1693},"obj":"Chemical"},{"id":"T29","span":{"begin":1695,"end":1702},"obj":"Chemical"}],"attributes":[{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_80551"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_30512"},{"id":"A28","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_9141"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T8","span":{"begin":1726,"end":1728},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T9","span":{"begin":1730,"end":1744},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A9","pred":"meddra_id","subj":"T9","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"},{"id":"A8","pred":"meddra_id","subj":"T8","obj":"http://purl.bioontology.org/ontology/MEDDRA/10021496"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T30","span":{"begin":56,"end":65},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T31","span":{"begin":86,"end":90},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T32","span":{"begin":110,"end":114},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T33","span":{"begin":174,"end":178},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T34","span":{"begin":481,"end":486},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T35","span":{"begin":513,"end":517},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T36","span":{"begin":617,"end":621},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T37","span":{"begin":694,"end":699},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T38","span":{"begin":1056,"end":1060},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T39","span":{"begin":1180,"end":1196},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T40","span":{"begin":1322,"end":1326},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T41","span":{"begin":1399,"end":1403},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T42","span":{"begin":1448,"end":1452},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T43","span":{"begin":1530,"end":1535},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T44","span":{"begin":1663,"end":1667},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T45","span":{"begin":1711,"end":1715},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T4","span":{"begin":560,"end":568},"obj":"Chemical"},{"id":"T5","span":{"begin":902,"end":910},"obj":"Chemical"}],"attributes":[{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

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{"project":"LitCovid-sample-sentences","denotations":[{"id":"T30","span":{"begin":0,"end":325},"obj":"Sentence"},{"id":"T31","span":{"begin":326,"end":540},"obj":"Sentence"},{"id":"T32","span":{"begin":541,"end":841},"obj":"Sentence"},{"id":"T33","span":{"begin":842,"end":1253},"obj":"Sentence"},{"id":"T34","span":{"begin":1254,"end":1572},"obj":"Sentence"},{"id":"T35","span":{"begin":1573,"end":1637},"obj":"Sentence"},{"id":"T36","span":{"begin":1638,"end":1765},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1","span":{"begin":1163,"end":1166},"obj":"Protein"}],"attributes":[{"id":"A1","pred":"uniprot_id","subj":"T1","obj":"https://www.uniprot.org/uniprot/P0C1F2"},{"id":"A2","pred":"uniprot_id","subj":"T1","obj":"https://www.uniprot.org/uniprot/P01532"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

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(a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T12","span":{"begin":188,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T13","span":{"begin":429,"end":449},"obj":"http://purl.obolibrary.org/obo/GO_0019882"},{"id":"T14","span":{"begin":499,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0050866"},{"id":"T15","span":{"begin":513,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T16","span":{"begin":602,"end":611},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T17","span":{"begin":680,"end":693},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T18","span":{"begin":856,"end":871},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T19","span":{"begin":971,"end":983},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T20","span":{"begin":1014,"end":1023},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T21","span":{"begin":1180,"end":1196},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T22","span":{"begin":1467,"end":1489},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T23","span":{"begin":1480,"end":1489},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T24","span":{"begin":1549,"end":1558},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T25","span":{"begin":1638,"end":1642},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T4","span":{"begin":1622,"end":1636},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T12","span":{"begin":188,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T13","span":{"begin":429,"end":449},"obj":"http://purl.obolibrary.org/obo/GO_0019882"},{"id":"T14","span":{"begin":499,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0050866"},{"id":"T15","span":{"begin":513,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T16","span":{"begin":602,"end":611},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T17","span":{"begin":680,"end":693},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T18","span":{"begin":856,"end":871},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T19","span":{"begin":971,"end":983},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T20","span":{"begin":1014,"end":1023},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T21","span":{"begin":1180,"end":1196},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T22","span":{"begin":1467,"end":1489},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T23","span":{"begin":1480,"end":1489},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T24","span":{"begin":1549,"end":1558},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T25","span":{"begin":1638,"end":1642},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":188,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0006909"},{"id":"T13","span":{"begin":429,"end":449},"obj":"http://purl.obolibrary.org/obo/GO_0019882"},{"id":"T14","span":{"begin":499,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0050866"},{"id":"T15","span":{"begin":513,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T16","span":{"begin":602,"end":611},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T17","span":{"begin":680,"end":693},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T18","span":{"begin":856,"end":871},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T19","span":{"begin":971,"end":983},"obj":"http://purl.obolibrary.org/obo/GO_0016791"},{"id":"T20","span":{"begin":1014,"end":1023},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T21","span":{"begin":1180,"end":1196},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T22","span":{"begin":1467,"end":1489},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T23","span":{"begin":1480,"end":1489},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T24","span":{"begin":1549,"end":1558},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T25","span":{"begin":1638,"end":1642},"obj":"http://purl.obolibrary.org/obo/GO_0001788"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-sentences","denotations":[{"id":"T30","span":{"begin":0,"end":325},"obj":"Sentence"},{"id":"T31","span":{"begin":326,"end":540},"obj":"Sentence"},{"id":"T32","span":{"begin":541,"end":841},"obj":"Sentence"},{"id":"T33","span":{"begin":842,"end":1253},"obj":"Sentence"},{"id":"T34","span":{"begin":1254,"end":1572},"obj":"Sentence"},{"id":"T35","span":{"begin":1573,"end":1637},"obj":"Sentence"},{"id":"T36","span":{"begin":1638,"end":1765},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T4","span":{"begin":1622,"end":1636},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Figure 1 Graphical representation of the FcγR effector functions. (a) Natural killer cell antibody‐dependent cell‐mediated cytotoxicity via FcγRIIIa. (b) Antibody‐dependent cell‐mediated phagocytosis, and/or trogocytosis of large immune complexes, by professional phagocytes via activating FcγR such as FcγRIIIa and FcγRIIa. Biological sequelae include the destruction of the ingested complexes which may also feed antigen into antigen‐presentation pathways of antigen‐presenting cells (APCs). (c) Inhibition of cell activation by FcγRIIb. The immunoreceptor tyrosine activation motif (ITAM)‐mediated signaling of B‐cell antigen receptors (left) or of activating FcγR (right) on innate immune cells such as macrophages and basophils is inhibited by IgG Fc‐mediated co‐cross‐linking of these activating receptors with the inhibitory FcγRIIb. This leads to phosphorylation of the FcγRIIb immunoreceptor tyrosine‐based inhibitory motif (ITIM) and consequently recruits the phosphatases that modulate the ITAM‐driven signaling responses leading to diminished cell responses. (d) Sweeping or internalization of small immune complexes leading to their removal and, in APC, to enhanced immune responses. (e) Scaffolding in which the FcγRs play a passive role. Typically involving FcγRIIb, no signal is generated in the effector cell but “super‐cross‐linking” of the opsonizing antibody by the FcγR on one cell generates a signal in the conjugated target cell, for example, induction of apoptosis or activation in agonistic expansion of cells and/or their secretion of cytokines. In extreme cases, this leads to life‐threatening cytokine storm. ADCC, antibody‐dependent cell‐mediated cytotoxicity; Ag, antigen; BCR, B‐cell receptor; Ig, immunoglobulin; NK, natural killer."}