PMC:7219429 / 12084-13415
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T64 | 32-39 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T65 | 51-62 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T66 | 136-147 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T67 | 348-356 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T68 | 604-615 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T69 | 818-829 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T70 | 975-986 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T71 | 1009-1020 | Body_part | denotes | ganglioside | http://purl.org/sig/ont/fma/fma82816 |
| T72 | 1085-1088 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T73 | 1184-1191 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T74 | 1325-1330 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T4 | 83-86 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
| T5 | 719-722 | Body_part | denotes | tip | http://purl.obolibrary.org/obo/UBERON_2001840 |
| T6 | 1228-1244 | Body_part | denotes | attachment sites | http://purl.obolibrary.org/obo/UBERON_4200047 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T40 | 15-23 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T41 | 94-97 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T43 | 232-240 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T44 | 546-549 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T46 | 567-570 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T119 | 49-50 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T120 | 133-134 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T121 | 374-379 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T122 | 571-574 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T123 | 575-576 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T124 | 781-784 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T125 | 785-786 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T126 | 816-817 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T127 | 1069-1076 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T128 | 1175-1176 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T129 | 1276-1277 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T130 | 1325-1330 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T216 | 32-39 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T217 | 51-62 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T218 | 125-128 | Chemical | denotes | ATM | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T219 | 136-147 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T220 | 348-356 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T221 | 392-398 | Chemical | denotes | corona | http://purl.obolibrary.org/obo/CHEBI_37409 |
| T222 | 413-421 | Chemical | denotes | electron | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T223 | 604-615 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T224 | 818-829 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T225 | 975-986 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T226 | 1009-1020 | Chemical | denotes | ganglioside | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T227 | 1122-1133 | Chemical | denotes | neurotoxins | http://purl.obolibrary.org/obo/CHEBI_50910 |
| T228 | 1184-1191 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 1309-1324 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into host |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T88 | 0-200 | Sentence | denotes | Given that the SARS-CoV-2 spike protein displays a ganglioside-binding site at the tip of its NTD [10], the possibility that ATM, as a “ganglioside mimic”, could also bind to this site was considered. |
| T89 | 201-305 | Sentence | denotes | The structural features of the SARS-CoV-2 spike in the prefusion conformation [20] are shown in Fig. 1c. |
| T90 | 306-440 | Sentence | denotes | It consists of three interdigitated spike proteins that provide the virus its typical corona-like shape in electron microscopy images. |
| T91 | 441-562 | Sentence | denotes | In each subunit, the most distant part from the viral envelope is divided into two separate domains, the NTD and the RBD. |
| T92 | 563-742 | Sentence | denotes | The NTD has a flat surface available for ganglioside binding [10], and this process is independent from the ACE-2 receptor recognition, which occurs at the tip of the RBD [11,20]. |
| T93 | 743-858 | Sentence | denotes | When seen from above, the viral spike has a typical triangle shape, with a ganglioside-binding domain at each apex. |
| T94 | 859-998 | Sentence | denotes | Thus, the spike central area is devoted to ACE-2 binding, leaving three peripheric flat surface areas available for ganglioside attachment. |
| T95 | 999-1139 | Sentence | denotes | Such dual ganglioside/receptor binding is commonly used by pathogenic viruses such as HIV-1 [28], [29], [30] and bacterial neurotoxins [16]. |
| T96 | 1140-1331 | Sentence | denotes | By combining the high affinity for a single protein receptor with multiple low affinity attachment sites, these pathogens have selected a very efficient pathway to gain entry into host cells. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 350 | 26-31 | Gene | denotes | spike | Gene:43740568 |
| 351 | 671-676 | Gene | denotes | ACE-2 | Gene:59272 |
| 352 | 902-907 | Gene | denotes | ACE-2 | Gene:59272 |
| 353 | 869-874 | Gene | denotes | spike | Gene:43740568 |
| 354 | 775-780 | Gene | denotes | spike | Gene:43740568 |
| 355 | 342-347 | Gene | denotes | spike | Gene:43740568 |
| 356 | 243-248 | Gene | denotes | spike | Gene:43740568 |
| 357 | 15-25 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 358 | 232-242 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 359 | 51-62 | Chemical | denotes | ganglioside | MESH:D005732 |
| 360 | 136-147 | Chemical | denotes | ganglioside | MESH:D005732 |
| 361 | 604-615 | Chemical | denotes | ganglioside | MESH:D005732 |
| 362 | 818-829 | Chemical | denotes | ganglioside | MESH:D005732 |
| 363 | 1009-1020 | Chemical | denotes | ganglioside | MESH:D005732 |
| 364 | 975-997 | Disease | denotes | ganglioside attachment | MESH:D005733 |
| 365 | 1085-1133 | Disease | denotes | HIV-1 [28], [29], [30] and bacterial neurotoxins | MESH:D016920 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32405156-32075877-48151023 | 280-282 | 32075877 | denotes | 20 |
| 32405156-32132184-48151024 | 735-737 | 32132184 | denotes | 11 |
| 32405156-32075877-48151025 | 738-740 | 32075877 | denotes | 20 |
| 32405156-31431523-48151026 | 1135-1137 | 31431523 | denotes | 16 |
| T54896 | 280-282 | 32075877 | denotes | 20 |
| T86066 | 735-737 | 32132184 | denotes | 11 |
| T70176 | 738-740 | 32075877 | denotes | 20 |
| T42537 | 1135-1137 | 31431523 | denotes | 16 |