PMC:7212949 / 45578-46647 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7212949","sourcedb":"PMC","sourceid":"7212949","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7212949","text":"COVID-19\nAcute renal dysfunction in COVID-19 at the time of presentation is not uncommon.92 , 104 , 105 The incidence of acute kidney injury either at presentation or later is as high as 15% with a high mortality rate of 60-90%106 , 107 (Table 4). Other researchers report albuminuria or proteinuria on admission in 44-63% patients, hematuria in 27%, elevated urea and creatinine in 13-27% and 14-19%, respectively, and low eGFR in 13%.104 , 105 There may also be imaging evidence of active renal edema and inflammation.104 Since renal dysfunction is early, an immunopathology response or direct viral injury may be contributing along with other systemic factors.20 , 92 Similar to other novel CoVs, renal involvement, acute or chronic, tends to associate with an adverse prognosis.22 , 105 , 107 The COVID-19 virus has been detected in renal tissue and in the urine.39 , 70 , 108 Due to the presence of ACE2 receptors in the Leydig cells and seminiferous tubules, it is also reasonable to speculate that testicular injury may be a consequence of COVID-19 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