PMC:7204657 / 81-1032
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
22 | 69-73 | Gene | denotes | IL-6 | Gene:3569 |
23 | 232-240 | Species | denotes | patients | Tax:9606 |
24 | 667-675 | Species | denotes | patients | Tax:9606 |
25 | 834-842 | Species | denotes | patients | Tax:9606 |
26 | 38-49 | Chemical | denotes | tocilizumab | MESH:C502936 |
27 | 181-192 | Chemical | denotes | tocilizumab | MESH:C502936 |
28 | 349-360 | Chemical | denotes | Tocilizumab | MESH:C502936 |
29 | 516-527 | Chemical | denotes | tocilizumab | MESH:C502936 |
30 | 749-760 | Chemical | denotes | tocilizumab | MESH:C502936 |
31 | 853-864 | Chemical | denotes | tocilizumab | MESH:C502936 |
32 | 162-170 | Disease | denotes | COVID-19 | MESH:C000657245 |
33 | 223-231 | Disease | denotes | COVID-19 | MESH:C000657245 |
34 | 421-441 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
35 | 446-466 | Disease | denotes | giant cell arteritis | MESH:D013700 |
36 | 581-599 | Disease | denotes | infectious disease | MESH:D003141 |
37 | 643-657 | Disease | denotes | critically ill | MESH:D016638 |
38 | 658-666 | Disease | denotes | COVID-19 | MESH:C000657245 |
39 | 900-914 | Disease | denotes | diverticulitis | MESH:D004238 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T2 | 83-91 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T3 | 113-121 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T4 | 452-456 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T5 | 762-772 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
T6 | 808-818 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T3 | 162-170 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T4 | 223-231 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 421-441 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
T6 | 432-441 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
T7 | 446-466 | Disease | denotes | giant cell arteritis | http://purl.obolibrary.org/obo/MONDO_0008538 |
T8 | 457-466 | Disease | denotes | arteritis | http://purl.obolibrary.org/obo/MONDO_0043494 |
T9 | 581-599 | Disease | denotes | infectious disease | http://purl.obolibrary.org/obo/MONDO_0005550 |
T10 | 658-666 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T11 | 762-784 | Disease | denotes | intestinal perforation | http://purl.obolibrary.org/obo/MONDO_0006807 |
T12 | 808-830 | Disease | denotes | intestinal perforation | http://purl.obolibrary.org/obo/MONDO_0006807 |
T13 | 900-914 | Disease | denotes | diverticulitis | http://purl.obolibrary.org/obo/MONDO_0004235 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 51-52 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T4 | 246-247 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 452-456 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T6 | 715-716 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T7 | 762-772 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
T8 | 762-772 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
T9 | 808-818 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
T10 | 808-818 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
T11 | 915-918 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T12 | 933-934 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 38-49 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
T2 | 69-71 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T4 | 181-192 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
T5 | 516-527 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
T6 | 749-760 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
T7 | 853-864 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4 | 0-171 | Sentence | denotes | Zhang et al. [1] discussed the use of tocilizumab, a monoclonal anti-IL-6 receptor antibody, in the treatment of cytokine release syndrome associated with severe COVID-19. |
T5 | 172-348 | Sentence | denotes | Although tocilizumab may be beneficial in selected COVID-19 patients with a counterproductive hyperinflammatory phenotype, the efficacy and safety of such treatment is unknown. |
T6 | 349-467 | Sentence | denotes | Tocilizumab is primarily used for rheumatological conditions, including rheumatoid arthritis and giant cell arteritis. |
T7 | 468-676 | Sentence | denotes | Rheumatologists have extensive experience using tocilizumab; however, this may not be the case for intensivists, infectious disease specialists, and other physicians treating critically ill COVID-19 patients. |
T8 | 677-789 | Sentence | denotes | Therefore, we would like to highlight a rare but feared complication of tocilizumab: intestinal perforation [2]. |
T9 | 790-951 | Sentence | denotes | The mechanism for intestinal perforation in patients receiving tocilizumab is not fully understood, but prior diverticulitis has been noted as a risk factor [2]. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 113-138 | Phenotype | denotes | cytokine release syndrome | http://purl.obolibrary.org/obo/HP_0033041 |
T3 | 421-441 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
T4 | 457-466 | Phenotype | denotes | arteritis | http://purl.obolibrary.org/obo/HP_0012089 |
T5 | 762-784 | Phenotype | denotes | intestinal perforation | http://purl.obolibrary.org/obo/HP_0031368 |
T6 | 808-830 | Phenotype | denotes | intestinal perforation | http://purl.obolibrary.org/obo/HP_0031368 |