PMC:7204657 / 81-1032 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7204657","sourcedb":"PMC","sourceid":"7204657","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7204657","text":"Zhang et al. [1] discussed the use of tocilizumab, a monoclonal anti-IL-6 receptor antibody, in the treatment of cytokine release syndrome associated with severe COVID-19. Although tocilizumab may be beneficial in selected COVID-19 patients with a counterproductive hyperinflammatory phenotype, the efficacy and safety of such treatment is unknown. Tocilizumab is primarily used for rheumatological conditions, including rheumatoid arthritis and giant cell arteritis. Rheumatologists have extensive experience using tocilizumab; however, this may not be the case for intensivists, infectious disease specialists, and other physicians treating critically ill COVID-19 patients. Therefore, we would like to highlight a rare but feared complication of tocilizumab: intestinal perforation [2]. The mechanism for intestinal perforation in patients receiving tocilizumab is not fully understood, but prior diverticulitis has been noted as a risk factor [2].","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"22","span":{"begin":69,"end":73},"obj":"Gene"},{"id":"23","span":{"begin":232,"end":240},"obj":"Species"},{"id":"24","span":{"begin":667,"end":675},"obj":"Species"},{"id":"25","span":{"begin":834,"end":842},"obj":"Species"},{"id":"26","span":{"begin":38,"end":49},"obj":"Chemical"},{"id":"27","span":{"begin":181,"end":192},"obj":"Chemical"},{"id":"28","span":{"begin":349,"end":360},"obj":"Chemical"},{"id":"29","span":{"begin":516,"end":527},"obj":"Chemical"},{"id":"30","span":{"begin":749,"end":760},"obj":"Chemical"},{"id":"31","span":{"begin":853,"end":864},"obj":"Chemical"},{"id":"32","span":{"begin":162,"end":170},"obj":"Disease"},{"id":"33","span":{"begin":223,"end":231},"obj":"Disease"},{"id":"34","span":{"begin":421,"end":441},"obj":"Disease"},{"id":"35","span":{"begin":446,"end":466},"obj":"Disease"},{"id":"36","span":{"begin":581,"end":599},"obj":"Disease"},{"id":"37","span":{"begin":643,"end":657},"obj":"Disease"},{"id":"38","span":{"begin":658,"end":666},"obj":"Disease"},{"id":"39","span":{"begin":900,"end":914},"obj":"Disease"}],"attributes":[{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:3569"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:9606"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:9606"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:9606"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:C502936"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:C502936"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:C502936"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:C502936"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:C502936"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:C502936"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:C000657245"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D001172"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D013700"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:D003141"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D016638"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:C000657245"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D004238"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"},{"subj":"39","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":83,"end":91},"obj":"Body_part"},{"id":"T3","span":{"begin":113,"end":121},"obj":"Body_part"},{"id":"T4","span":{"begin":452,"end":456},"obj":"Body_part"},{"id":"T5","span":{"begin":762,"end":772},"obj":"Body_part"},{"id":"T6","span":{"begin":808,"end":818},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma7199"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T3","span":{"begin":162,"end":170},"obj":"Disease"},{"id":"T4","span":{"begin":223,"end":231},"obj":"Disease"},{"id":"T5","span":{"begin":421,"end":441},"obj":"Disease"},{"id":"T6","span":{"begin":432,"end":441},"obj":"Disease"},{"id":"T7","span":{"begin":446,"end":466},"obj":"Disease"},{"id":"T8","span":{"begin":457,"end":466},"obj":"Disease"},{"id":"T9","span":{"begin":581,"end":599},"obj":"Disease"},{"id":"T10","span":{"begin":658,"end":666},"obj":"Disease"},{"id":"T11","span":{"begin":762,"end":784},"obj":"Disease"},{"id":"T12","span":{"begin":808,"end":830},"obj":"Disease"},{"id":"T13","span":{"begin":900,"end":914},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0008383"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005578"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0008538"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0043494"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0006807"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0006807"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0004235"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T3","span":{"begin":51,"end":52},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":246,"end":247},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":452,"end":456},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":715,"end":716},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":762,"end":772},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T8","span":{"begin":762,"end":772},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T9","span":{"begin":808,"end":818},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T10","span":{"begin":808,"end":818},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T11","span":{"begin":915,"end":918},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T12","span":{"begin":933,"end":934},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":38,"end":49},"obj":"Chemical"},{"id":"T2","span":{"begin":69,"end":71},"obj":"Chemical"},{"id":"T4","span":{"begin":181,"end":192},"obj":"Chemical"},{"id":"T5","span":{"begin":516,"end":527},"obj":"Chemical"},{"id":"T6","span":{"begin":749,"end":760},"obj":"Chemical"},{"id":"T7","span":{"begin":853,"end":864},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A3","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T4","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T5","span":{"begin":172,"end":348},"obj":"Sentence"},{"id":"T6","span":{"begin":349,"end":467},"obj":"Sentence"},{"id":"T7","span":{"begin":468,"end":676},"obj":"Sentence"},{"id":"T8","span":{"begin":677,"end":789},"obj":"Sentence"},{"id":"T9","span":{"begin":790,"end":951},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":113,"end":138},"obj":"Phenotype"},{"id":"T3","span":{"begin":421,"end":441},"obj":"Phenotype"},{"id":"T4","span":{"begin":457,"end":466},"obj":"Phenotype"},{"id":"T5","span":{"begin":762,"end":784},"obj":"Phenotype"},{"id":"T6","span":{"begin":808,"end":830},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0001370"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0012089"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0031368"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0031368"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ecab","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9394"},{"id":"LitCovid-PD-MONDO","color":"#93aeec"},{"id":"LitCovid-PD-CLO","color":"#c8ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93e2"},{"id":"LitCovid-sentences","color":"#93ecdb"},{"id":"LitCovid-PD-HP","color":"#ecc193"}]}]}}