PMC:7200337 / 106316-107329 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7200337","sourcedb":"PMC","sourceid":"7200337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7200337","text":"Although the antibodies targeting the RBD of the S protein have greater potential for providing cross-protective immunity, other fragments of the S protein and additional viral proteins have been investigated as target epitopes, especially for T cells. Researchers have taken advantage of the genetic similarity between SARS-CoV-2 and SARS-CoV-1 and MERS-CoV and bioinformatics approaches to rapidly identify potential B and T cell epitopes in the S and other proteins, with many studies providing data regarding antigen presentation and antibody-binding properties and one study looking into the predicted evolution of epitopes (Ahmed et al., 2020, Baruah and Bose, 2020, Bhattacharya et al., 2020, Fast et al., 2020, Grifoni et al., 2020, Lon et al., 2020, Zheng and Song, 2020). While the S protein has been found to be the most immunodominant protein in SARS-CoV-2, the M and N proteins also contain B and T cell epitopes, including some with high conservation with SARS-CoV-1 epitopes (Grifoni et al., 2020).","tracks":[{"project":"2_test","denotations":[{"id":"32505227-32022276-46575455","span":{"begin":667,"end":671},"obj":"32022276"},{"id":"32505227-32183941-46575456","span":{"begin":735,"end":739},"obj":"32183941"},{"id":"32505227-32132669-46575457","span":{"begin":775,"end":779},"obj":"32132669"},{"id":"32505227-32183941-46575458","span":{"begin":1007,"end":1011},"obj":"32183941"},{"id":"T35612","span":{"begin":667,"end":671},"obj":"32022276"},{"id":"T23493","span":{"begin":735,"end":739},"obj":"32183941"},{"id":"T15418","span":{"begin":775,"end":779},"obj":"32132669"},{"id":"T66082","span":{"begin":1007,"end":1011},"obj":"32183941"}],"attributes":[{"subj":"32505227-32022276-46575455","pred":"source","obj":"2_test"},{"subj":"32505227-32183941-46575456","pred":"source","obj":"2_test"},{"subj":"32505227-32132669-46575457","pred":"source","obj":"2_test"},{"subj":"32505227-32183941-46575458","pred":"source","obj":"2_test"},{"subj":"T35612","pred":"source","obj":"2_test"},{"subj":"T23493","pred":"source","obj":"2_test"},{"subj":"T15418","pred":"source","obj":"2_test"},{"subj":"T66082","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T30","span":{"begin":51,"end":58},"obj":"Body_part"},{"id":"T31","span":{"begin":148,"end":155},"obj":"Body_part"},{"id":"T32","span":{"begin":177,"end":185},"obj":"Body_part"},{"id":"T33","span":{"begin":246,"end":251},"obj":"Body_part"},{"id":"T34","span":{"begin":427,"end":431},"obj":"Body_part"},{"id":"T35","span":{"begin":460,"end":468},"obj":"Body_part"},{"id":"T36","span":{"begin":538,"end":546},"obj":"Body_part"},{"id":"T37","span":{"begin":794,"end":801},"obj":"Body_part"},{"id":"T38","span":{"begin":847,"end":854},"obj":"Body_part"},{"id":"T39","span":{"begin":882,"end":890},"obj":"Body_part"},{"id":"T40","span":{"begin":912,"end":916},"obj":"Body_part"}],"attributes":[{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T609","span":{"begin":320,"end":328},"obj":"Disease"},{"id":"T610","span":{"begin":335,"end":343},"obj":"Disease"},{"id":"T611","span":{"begin":858,"end":866},"obj":"Disease"},{"id":"T612","span":{"begin":970,"end":978},"obj":"Disease"}],"attributes":[{"id":"A609","pred":"mondo_id","subj":"T609","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A610","pred":"mondo_id","subj":"T610","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A611","pred":"mondo_id","subj":"T611","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A612","pred":"mondo_id","subj":"T612","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T609","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T610","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T611","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T612","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T84","span":{"begin":244,"end":251},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T85","span":{"begin":419,"end":420},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T86","span":{"begin":425,"end":431},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T87","span":{"begin":802,"end":805},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T88","span":{"begin":904,"end":905},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T89","span":{"begin":910,"end":916},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"attributes":[{"subj":"T84","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T50430","span":{"begin":51,"end":58},"obj":"Chemical"},{"id":"T25409","span":{"begin":148,"end":155},"obj":"Chemical"},{"id":"T90657","span":{"begin":177,"end":185},"obj":"Chemical"},{"id":"T83746","span":{"begin":460,"end":468},"obj":"Chemical"},{"id":"T81019","span":{"begin":513,"end":520},"obj":"Chemical"},{"id":"T98403","span":{"begin":794,"end":801},"obj":"Chemical"},{"id":"T30623","span":{"begin":847,"end":854},"obj":"Chemical"},{"id":"T56251","span":{"begin":882,"end":890},"obj":"Chemical"}],"attributes":[{"id":"A74925","pred":"chebi_id","subj":"T50430","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A19489","pred":"chebi_id","subj":"T25409","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A68217","pred":"chebi_id","subj":"T90657","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A63022","pred":"chebi_id","subj":"T83746","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A54921","pred":"chebi_id","subj":"T81019","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A75941","pred":"chebi_id","subj":"T98403","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A79014","pred":"chebi_id","subj":"T30623","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A42840","pred":"chebi_id","subj":"T56251","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T50430","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25409","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T90657","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T83746","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T81019","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98403","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30623","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56251","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T10","span":{"begin":513,"end":533},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"attributes":[{"subj":"T10","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3531","span":{"begin":874,"end":875},"obj":"Gene"},{"id":"3532","span":{"begin":880,"end":881},"obj":"Gene"},{"id":"3533","span":{"begin":817,"end":819},"obj":"Gene"},{"id":"3534","span":{"begin":389,"end":391},"obj":"Gene"},{"id":"3535","span":{"begin":320,"end":330},"obj":"Species"},{"id":"3536","span":{"begin":335,"end":343},"obj":"Species"},{"id":"3537","span":{"begin":350,"end":358},"obj":"Species"},{"id":"3538","span":{"begin":858,"end":868},"obj":"Species"},{"id":"3539","span":{"begin":970,"end":978},"obj":"Species"}],"attributes":[{"id":"A3531","pred":"tao:has_database_id","subj":"3531","obj":"Gene:43740571"},{"id":"A3532","pred":"tao:has_database_id","subj":"3532","obj":"Gene:43740575"},{"id":"A3533","pred":"tao:has_database_id","subj":"3533","obj":"Gene:6999"},{"id":"A3534","pred":"tao:has_database_id","subj":"3534","obj":"Gene:6999"},{"id":"A3535","pred":"tao:has_database_id","subj":"3535","obj":"Tax:2697049"},{"id":"A3536","pred":"tao:has_database_id","subj":"3536","obj":"Tax:694009"},{"id":"A3537","pred":"tao:has_database_id","subj":"3537","obj":"Tax:1335626"},{"id":"A3538","pred":"tao:has_database_id","subj":"3538","obj":"Tax:2697049"},{"id":"A3539","pred":"tao:has_database_id","subj":"3539","obj":"Tax:694009"},{"subj":"3531","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3532","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3533","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3534","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3535","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3536","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3537","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3538","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3539","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T635","span":{"begin":0,"end":252},"obj":"Sentence"},{"id":"T636","span":{"begin":253,"end":781},"obj":"Sentence"},{"id":"T637","span":{"begin":782,"end":1013},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T635","pred":"source","obj":"LitCovid-sentences"},{"subj":"T636","pred":"source","obj":"LitCovid-sentences"},{"subj":"T637","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecaa","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9395"},{"id":"LitCovid-PD-MONDO","color":"#93afec"},{"id":"LitCovid-PD-CLO","color":"#c9ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93e3"},{"id":"LitCovid-PD-GO-BP","color":"#93ecda"},{"id":"LitCovid-PubTator","color":"#ecc093"},{"id":"LitCovid-sentences","color":"#a693ec"}]}]}}