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PMC:7195088 / 68233-69458 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
822 1158-1176 Chemical denotes hydroxychloroquine MESH:D006886
1990 129-136 Species denotes patient Tax:9606
1991 387-395 Species denotes patients Tax:9606
1992 521-529 Species denotes patients Tax:9606
1993 641-649 Species denotes patients Tax:9606
1994 651-659 Species denotes patients Tax:9606
1995 808-816 Species denotes patients Tax:9606
1996 990-998 Species denotes patients Tax:9606
1997 1216-1224 Species denotes patients Tax:9606
1998 557-566 Species denotes influenza Tax:11520
1999 57-63 Chemical denotes oxygen MESH:D010100
2000 495-506 Chemical denotes oseltamivir MESH:D053139
2001 926-944 Chemical denotes hydroxychloroquine MESH:D006886
2003 201-209 Disease denotes asthenia MESH:D001247
2004 216-221 Disease denotes fever MESH:D005334
2005 234-239 Disease denotes cough MESH:D003371
2006 401-421 Disease denotes SARS-CoV-2 infection MESH:C000657245
2007 665-669 Disease denotes ARDS MESH:D012128
2008 695-719 Disease denotes ARDS respiratory failure MESH:D012131
2009 799-807 Disease denotes COVID-19 MESH:C000657245
2010 981-989 Disease denotes COVID-19 MESH:C000657245
2011 1146-1154 Disease denotes toxicity MESH:D064420

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T118 279-283 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T55 151-174 Body_part denotes respiratory or systemic http://purl.obolibrary.org/obo/UBERON_0001004
T56 279-283 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T108 201-209 Phenotype denotes asthenia http://purl.obolibrary.org/obo/HP_0025406
T109 216-221 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T110 234-239 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T111 700-719 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T386 401-409 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T387 412-421 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T388 557-566 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T389 665-669 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T390 695-699 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T391 700-719 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T392 799-807 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 981-989 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T376 151-174 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory or systemic
T377 279-283 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T378 279-283 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T17049 57-63 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T3796 339-348 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T49322 495-506 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T90742 926-944 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T28849 1158-1176 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T478 0-296 Sentence denotes Supportive therapy (symptomatic therapy, rehydration and oxygen supplementation, if necessary) should be provided as soon as the patient presents with respiratory or systemic symptoms including severe asthenia, high fever, persistent cough and/or clinical or radiologic signs of lung involvement.
T479 297-568 Sentence denotes Pending further evidence, in our opinion, antiviral treatments should not be initiated in patients with SARS-CoV-2 infection outside RCT or compassionate-use programmes (with the exception of early oseltamivir initiation in patients with suspected concomitant influenza).
T480 569-841 Sentence denotes Corticosteroids should be initiated early in well-defined categories of patients (patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections), while their role in other COVID-19 patients still remains uncertain.
T481 842-1225 Sentence denotes Although based on low-level evidence and pending RCT results, in our opinion, early hydroxychloroquine administration may be considered in COVID-19 patients who have moderate to severe symptoms, whereas further data are needed to better delineate the true balance between possible favourable effects and toxicity of hydroxychloroquine in mildly symptomatic and asymptomatic patients.