PMC:7190487 / 2875-3705 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7190487","sourcedb":"PMC","sourceid":"7190487","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7190487","text":"2.2 Metformin-mTOR-Coronavirus\nThe mammalian target of rapamycin (mTOR) signalling plays an important role in the pathogenesis of influenza, besides modulating antibody response for cross-protective immunity against infective influenza viruses. Metformin activates AMPK via liver kinase B1 (LKB1), inhibiting the mTOR pathway. It also indirectly attenuates AKT activation through phosphorylation of insulin receptor substrate 1 (IRS-1) resulting in inhibition of the mTOR signalling cascade [11]. Other biguanide molecules, buformin and phenformin have been associated with better survival outcomes in animal models of influenza [12], [13]. Further, the PI3K/AKT/mTOR pathway plays major roles in MERS‑CoV infection [14]. Since metformin inhibits the same pathway, it would be interesting to decipher its role against 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