> top > docs > PMC:7190487 > spans > 2875-3705 > annotations

PMC:7190487 / 2875-3705 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T15 161-169 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T16 275-280 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T17 400-407 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 275-280 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T19 131-140 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T20 227-236 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T21 620-629 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T22 707-716 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 819-827 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T40 73-83 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T41 237-244 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T42 256-265 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T43 275-280 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T44 275-280 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T45 362-372 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T46 400-416 http://purl.obolibrary.org/obo/PR_000009064 denotes insulin receptor
T47 473-483 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T48 493-495 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T49 603-609 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T42 5-14 Chemical denotes Metformin http://purl.obolibrary.org/obo/CHEBI_6801
T43 56-65 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T44 246-255 Chemical denotes Metformin http://purl.obolibrary.org/obo/CHEBI_6801
T45 400-407 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T46 504-513 Chemical denotes biguanide http://purl.obolibrary.org/obo/CHEBI_3095
T47 514-523 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T48 538-548 Chemical denotes phenformin http://purl.obolibrary.org/obo/CHEBI_8064
T49 729-738 Chemical denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T27 73-83 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T28 115-127 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T29 266-270 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T30 266-270 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T31 266-270 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK
T32 381-396 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T33 473-491 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling cascade
T34 473-483 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T35 655-659 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T26 0-31 Sentence denotes 2.2 Metformin-mTOR-Coronavirus
T27 32-245 Sentence denotes The mammalian target of rapamycin (mTOR) signalling plays an important role in the pathogenesis of influenza, besides modulating antibody response for cross-protective immunity against infective influenza viruses.
T28 246-327 Sentence denotes Metformin activates AMPK via liver kinase B1 (LKB1), inhibiting the mTOR pathway.
T29 328-497 Sentence denotes It also indirectly attenuates AKT activation through phosphorylation of insulin receptor substrate 1 (IRS-1) resulting in inhibition of the mTOR signalling cascade [11].
T30 498-641 Sentence denotes Other biguanide molecules, buformin and phenformin have been associated with better survival outcomes in animal models of influenza [12], [13].
T31 642-722 Sentence denotes Further, the PI3K/AKT/mTOR pathway plays major roles in MERS‑CoV infection [14].
T32 723-830 Sentence denotes Since metformin inhibits the same pathway, it would be interesting to decipher its role against SARS-CoV-2.

2_test

Id Subject Object Predicate Lexical cue
32360697-21421541-25244887 493-495 21421541 denotes 11
32360697-5447272-25244888 631-633 5447272 denotes 12
32360697-32313883-25244889 637-639 32313883 denotes 13
32360697-25487801-25244890 718-720 25487801 denotes 14

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
126 15-19 Gene denotes mTOR Gene:2475
127 5-14 Chemical denotes Metformin MESH:D008687
150 36-65 Gene denotes mammalian target of rapamycin Gene:2475
151 67-71 Gene denotes mTOR Gene:2475
152 266-270 Gene denotes AMPK Gene:5563
153 275-290 Gene denotes liver kinase B1 Gene:6794
154 292-296 Gene denotes LKB1 Gene:6794
155 314-318 Gene denotes mTOR Gene:2475
156 358-361 Gene denotes AKT Gene:207
157 400-428 Gene denotes insulin receptor substrate 1 Gene:3667
158 430-435 Gene denotes IRS-1 Gene:3667
159 468-472 Gene denotes mTOR Gene:2475
160 660-663 Gene denotes AKT Gene:207
161 664-668 Gene denotes mTOR Gene:2475
162 227-244 Species denotes influenza viruses Tax:11308
163 819-829 Species denotes SARS-CoV-2 Tax:2697049
164 131-140 Species denotes influenza Tax:11308
165 620-629 Species denotes influenza Tax:11308
166 246-255 Chemical denotes Metformin MESH:D008687
167 504-513 Chemical denotes biguanide MESH:D001645
168 525-533 Chemical denotes buformin MESH:D002026
169 538-548 Chemical denotes phenformin MESH:D010629
170 729-738 Chemical denotes metformin MESH:D008687
171 698-716 Disease denotes MERS‑CoV infection MESH:D018352