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PMC:7172841 / 958-1679 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T11 98-109 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T12 217-220 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T13 278-286 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T14 414-424 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T15 514-517 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T16 529-538 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T17 546-550 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 555-562 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T19 558-562 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T15 170-178 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 239-250 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T17 308-320 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T18 364-372 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 414-444 Disease denotes macrophage activation syndrome http://purl.obolibrary.org/obo/MONDO_0015545
T20 455-474 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T21 604-612 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 659-667 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 659-663 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T11 15-20 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T12 425-435 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T13 494-495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 529-538 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T15 542-545 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T16 546-550 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17 555-562 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T8 15-20 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T9 199-201 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T11 221-223 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T12 518-520 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T13 616-618 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T9 278-297 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T10 308-320 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T11 414-435 http://purl.obolibrary.org/obo/GO_0042116 denotes macrophage activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T10 111-321 Sentence denotes Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation.
T11 323-341 Sentence denotes Graphical Abstract
T12 343-353 Sentence denotes Highlights
T13 354-444 Sentence denotes • Severe COVID-19 patients display immune dysregulation or macrophage activation syndrome
T14 445-538 Sentence denotes • Severe respiratory failure is associated with a major decrease of HLA-DR on CD14 monocytes
T15 539-612 Sentence denotes • CD4 cell and NK cell cytopenias are characteristics of severe COVID-19
T16 613-701 Sentence denotes • IL-6 blocker Tocilizumab partially rescues SARS-CoV-2-associated immune dysregulation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 139-159 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T7 239-250 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T8 390-410 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T9 455-474 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T10 681-701 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T35 21-32 DG_35 denotes Tocilizumab
T36 86-97 CL:0000080 denotes circulating
T37 98-109 CL:0000542 denotes lymphocytes
T38 139-145 UBERON:0002405 denotes immune
T39 146-159 GO:0065007 denotes dysregulation
T40 170-178 SP_7 denotes COVID-19
T41 199-203 PR:000001393 denotes IL-6
T42 217-220 PR:000029150 denotes HLA
T43 224-234 GO:0010467 denotes expression
T44 364-372 SP_7 denotes COVID-19
T45 390-396 UBERON:0002405 denotes immune
T46 397-410 GO:0065007 denotes dysregulation
T47 414-424 CL:0000235;GO:0042116 denotes macrophage
T48 425-435 GO:0042116 denotes activation
T49 455-466 UBERON:0001004 denotes respiratory
T50 514-517 PR:000029150 denotes HLA
T51 524-528 PR:000001889 denotes CD14
T52 529-538 CL:0000576 denotes monocytes
T53 604-612 SP_7 denotes COVID-19
T54 616-620 PR:000001393 denotes IL-6
T55 629-640 DG_35 denotes Tocilizumab
T56 659-669 SP_7 denotes SARS-CoV-2
T57 688-701 GO:0065007 denotes dysregulation
T10312 21-32 DG_35 denotes Tocilizumab
T74668 86-97 CL:0000080 denotes circulating
T90672 98-109 CL:0000542 denotes lymphocytes
T2958 139-145 UBERON:0002405 denotes immune
T86620 146-159 GO:0065007 denotes dysregulation
T3195 170-178 SP_7 denotes COVID-19
T88472 199-203 PR:000001393 denotes IL-6
T6458 217-220 PR:000029150 denotes HLA
T72315 224-234 GO:0010467 denotes expression
T19296 364-372 SP_7 denotes COVID-19
T3907 390-396 UBERON:0002405 denotes immune
T65562 397-410 GO:0065007 denotes dysregulation
T99154 414-424 CL:0000235;GO:0042116 denotes macrophage
T21216 425-435 GO:0042116 denotes activation
T35889 455-466 UBERON:0001004 denotes respiratory
T52417 514-517 PR:000029150 denotes HLA
T73916 524-528 PR:000001889 denotes CD14
T86003 529-538 CL:0000576 denotes monocytes
T91561 604-612 SP_7 denotes COVID-19
T288 616-620 PR:000001393 denotes IL-6
T45776 629-640 DG_35 denotes Tocilizumab
T71931 659-669 SP_7 denotes SARS-CoV-2
T97850 688-701 GO:0065007 denotes dysregulation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
43 199-203 Gene denotes IL-6 Gene:3569
48 46-54 Species denotes patients Tax:9606
52 21-32 Chemical denotes Tocilizumab MESH:C502936
63 170-178 Disease denotes COVID-19 MESH:C000657245
64 239-250 Disease denotes lymphopenia MESH:D008231
65 302-320 Disease denotes hyper-inflammation MESH:D007249
69 373-381 Species denotes patients Tax:9606
70 364-372 Disease denotes COVID-19 MESH:C000657245
71 414-444 Disease denotes macrophage activation syndrome MESH:D055501
74 524-528 Gene denotes CD14 Gene:929
75 455-474 Disease denotes respiratory failure MESH:D012131
79 542-545 Gene denotes CD4 Gene:920
80 555-573 Disease denotes NK cell cytopenias MESH:D054066
81 604-612 Disease denotes COVID-19 MESH:C000657245
85 616-620 Gene denotes IL-6 Gene:3569
86 659-669 Species denotes SARS-CoV-2 Tax:2697049
87 629-640 Chemical denotes Tocilizumab MESH:C502936