PMC:7172841 / 958-1679 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7172841","sourcedb":"PMC","sourceid":"7172841","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7172841","text":"cilizumab; off-label Tocilizumab treatment of patients was accompanied by increase in circulating lymphocytes. Thus, the unique pattern of immune dysregulation in severe COVID-19 is characterized by IL-6-mediated low HLA-DR expression and lymphopenia, associated with sustained cytokine production and hyper-inflammation.\n\nGraphical Abstract\n\nHighlights\n• Severe COVID-19 patients display immune dysregulation or macrophage activation syndrome\n• Severe respiratory failure is associated with a major decrease of HLA-DR on CD14 monocytes\n• CD4 cell and NK cell cytopenias are characteristics of severe COVID-19\n• IL-6 blocker Tocilizumab partially rescues SARS-CoV-2-associated immune dysregulation\n\nProper management 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