PMC:7172841 / 20179-21220 JSON TXT

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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T115","span":{"begin":108,"end":115},"obj":"Body_part"}],"attributes":[{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T196","span":{"begin":146,"end":154},"obj":"Disease"},{"id":"T197","span":{"begin":146,"end":150},"obj":"Disease"},{"id":"T198","span":{"begin":287,"end":299},"obj":"Disease"},{"id":"T199","span":{"begin":371,"end":379},"obj":"Disease"},{"id":"T200","span":{"begin":924,"end":933},"obj":"Disease"}],"attributes":[{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A199","pred":"mondo_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A200","pred":"mondo_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T185","span":{"begin":3,"end":4},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T186","span":{"begin":610,"end":620},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T95","span":{"begin":65,"end":75},"obj":"Chemical"},{"id":"T96","span":{"begin":87,"end":89},"obj":"Chemical"},{"id":"T98","span":{"begin":108,"end":115},"obj":"Chemical"},{"id":"T99","span":{"begin":460,"end":462},"obj":"Chemical"},{"id":"T101","span":{"begin":653,"end":655},"obj":"Chemical"},{"id":"T103","span":{"begin":799,"end":801},"obj":"Chemical"},{"id":"T105","span":{"begin":865,"end":867},"obj":"Chemical"}],"attributes":[{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A97","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A100","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A102","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A104","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A106","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T28","span":{"begin":287,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T155","span":{"begin":0,"end":157},"obj":"Sentence"},{"id":"T156","span":{"begin":158,"end":300},"obj":"Sentence"},{"id":"T157","span":{"begin":301,"end":446},"obj":"Sentence"},{"id":"T158","span":{"begin":447,"end":641},"obj":"Sentence"},{"id":"T159","span":{"begin":642,"end":870},"obj":"Sentence"},{"id":"T160","span":{"begin":871,"end":1041},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T76","span":{"begin":534,"end":554},"obj":"Phenotype"},{"id":"T77","span":{"begin":713,"end":733},"obj":"Phenotype"},{"id":"T78","span":{"begin":924,"end":933},"obj":"Phenotype"}],"attributes":[{"id":"A76","pred":"hp_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/HP_0002958"},{"id":"A77","pred":"hp_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/HP_0002958"},{"id":"A78","pred":"hp_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"As a next step, we measured circulating concentrations of TNF-α, interferon-γ (IFN-γ), IL-6, and C-reactive protein (CRP) in patients infected by SARS-CoV-2. IFN-γ was below the limit of detection in all patients (data not shown), indicating that Th1 responses do not contribute to over-inflammation. No differences of circulating TNF-α concentrations were found between COVID-19 patients at the three states of immune classification (Figure 4J). In contrast, IL-6 and CRP concentrations were significantly higher among patients with immune dysregulation than among patients at an intermediate state of immune activation (Figures 4K and 4L). Given that IL-6 was below the limit of detection in some patients with immune dysregulation, we divided them into two groups as follows: seven patients with IL-6 below the limit of detection and 14 patients with detectable IL-6. Their severity was similar given that SOFA score and pneumonia severity indexes were similar (p values of comparisons were 0.937 and 0.877, respectively; data not shown)."}

LitCovid-PMC-OGER-BB

LitCovid-PubTator

PMC:7172841 / 20179-21220 JSONTXT

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PMC:7172841 / 20179-21220 JSON TXT