PMC:7161517 / 29803-30611
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7161517","sourcedb":"PMC","sourceid":"7161517","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7161517","text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T179","span":{"begin":119,"end":123},"obj":"Body_part"},{"id":"T180","span":{"begin":171,"end":179},"obj":"Body_part"},{"id":"T181","span":{"begin":206,"end":219},"obj":"Body_part"},{"id":"T182","span":{"begin":206,"end":210},"obj":"Body_part"},{"id":"T183","span":{"begin":266,"end":271},"obj":"Body_part"},{"id":"T184","span":{"begin":365,"end":370},"obj":"Body_part"}],"attributes":[{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T179","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T180","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T181","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T182","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T183","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T184","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T159","span":{"begin":3,"end":11},"obj":"Disease"},{"id":"T160","span":{"begin":241,"end":250},"obj":"Disease"},{"id":"T161","span":{"begin":798,"end":807},"obj":"Disease"}],"attributes":[{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T281","span":{"begin":119,"end":123},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T282","span":{"begin":206,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T283","span":{"begin":211,"end":219},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T284","span":{"begin":266,"end":271},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T285","span":{"begin":350,"end":370},"obj":"http://purl.obolibrary.org/obo/CL_0000228"},{"id":"T286","span":{"begin":387,"end":392},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T287","span":{"begin":444,"end":449},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T288","span":{"begin":604,"end":609},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T281","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T322","span":{"begin":171,"end":179},"obj":"Chemical"}],"attributes":[{"id":"A322","pred":"chebi_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T78","span":{"begin":155,"end":168},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T79","span":{"begin":294,"end":303},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T80","span":{"begin":337,"end":346},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T81","span":{"begin":513,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T82","span":{"begin":537,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0019068"},{"id":"T83","span":{"begin":637,"end":647},"obj":"http://purl.obolibrary.org/obo/GO_0006887"},{"id":"T84","span":{"begin":677,"end":692},"obj":"http://purl.obolibrary.org/obo/GO_0019068"},{"id":"T85","span":{"begin":697,"end":707},"obj":"http://purl.obolibrary.org/obo/GO_0006887"}],"attributes":[{"subj":"T78","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T182","span":{"begin":0,"end":336},"obj":"Sentence"},{"id":"T183","span":{"begin":337,"end":475},"obj":"Sentence"},{"id":"T184","span":{"begin":476,"end":653},"obj":"Sentence"},{"id":"T185","span":{"begin":654,"end":808},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T182","pred":"source","obj":"LitCovid-sentences"},{"subj":"T183","pred":"source","obj":"LitCovid-sentences"},{"subj":"T184","pred":"source","obj":"LitCovid-sentences"},{"subj":"T185","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T978","span":{"begin":3,"end":13},"obj":"SP_7"},{"id":"T979","span":{"begin":26,"end":30},"obj":"G_3;PG_10;PR:000003622"},{"id":"T980","span":{"begin":86,"end":90},"obj":"G_3;PG_10;PR:000003622"},{"id":"T981","span":{"begin":91,"end":102},"obj":"SO:0000243"},{"id":"T982","span":{"begin":201,"end":219},"obj":"GO:0033644"},{"id":"T983","span":{"begin":307,"end":321},"obj":"GO:0005634"},{"id":"T984","span":{"begin":337,"end":349},"obj":"GO:0048468"},{"id":"T985","span":{"begin":350,"end":364},"obj":"GO:0005634;CL:0000228"},{"id":"T986","span":{"begin":365,"end":370},"obj":"CL:0000228"},{"id":"T987","span":{"begin":387,"end":392},"obj":"NCBITaxon:10239"},{"id":"T988","span":{"begin":444,"end":449},"obj":"NCBITaxon:10239"},{"id":"T989","span":{"begin":459,"end":469},"obj":"GO:0042571"},{"id":"T990","span":{"begin":497,"end":508},"obj":"GO:0006260"},{"id":"T991","span":{"begin":537,"end":543},"obj":"GO:0019012;GO:0019068"},{"id":"T992","span":{"begin":544,"end":552},"obj":"GO:0019068"},{"id":"T993","span":{"begin":560,"end":565},"obj":"GO:0005794"},{"id":"T994","span":{"begin":604,"end":609},"obj":"NCBITaxon:10239"},{"id":"T995","span":{"begin":613,"end":621},"obj":"GO:0031982"},{"id":"T996","span":{"begin":637,"end":647},"obj":"GO:0006887"},{"id":"T997","span":{"begin":677,"end":692},"obj":"GO:0019068"},{"id":"T998","span":{"begin":697,"end":707},"obj":"GO:0006887"},{"id":"T999","span":{"begin":726,"end":730},"obj":"G_3;PG_10;PR:000003622"},{"id":"T28163","span":{"begin":3,"end":13},"obj":"SP_7"},{"id":"T43635","span":{"begin":26,"end":30},"obj":"G_3;PG_10;PR:000003622"},{"id":"T8828","span":{"begin":86,"end":90},"obj":"G_3;PG_10;PR:000003622"},{"id":"T1098","span":{"begin":91,"end":102},"obj":"SO:0000243"},{"id":"T6321","span":{"begin":201,"end":219},"obj":"GO:0033644"},{"id":"T55209","span":{"begin":307,"end":321},"obj":"GO:0005634"},{"id":"T36761","span":{"begin":337,"end":349},"obj":"GO:0048468"},{"id":"T98942","span":{"begin":350,"end":364},"obj":"GO:0005634;CL:0000228"},{"id":"T72211","span":{"begin":365,"end":370},"obj":"CL:0000228"},{"id":"T30799","span":{"begin":387,"end":392},"obj":"NCBITaxon:10239"},{"id":"T11178","span":{"begin":444,"end":449},"obj":"NCBITaxon:10239"},{"id":"T64611","span":{"begin":459,"end":469},"obj":"GO:0042571"},{"id":"T23970","span":{"begin":497,"end":508},"obj":"GO:0006260"},{"id":"T77931","span":{"begin":537,"end":543},"obj":"GO:0019012;GO:0019068"},{"id":"T3886","span":{"begin":544,"end":552},"obj":"GO:0019068"},{"id":"T94309","span":{"begin":560,"end":565},"obj":"GO:0005794"},{"id":"T20019","span":{"begin":604,"end":609},"obj":"NCBITaxon:10239"},{"id":"T27779","span":{"begin":613,"end":621},"obj":"GO:0031982"},{"id":"T75315","span":{"begin":637,"end":647},"obj":"GO:0006887"},{"id":"T94094","span":{"begin":677,"end":692},"obj":"GO:0019068"},{"id":"T55582","span":{"begin":697,"end":707},"obj":"GO:0006887"},{"id":"T20788","span":{"begin":726,"end":730},"obj":"G_3;PG_10;PR:000003622"}],"attributes":[{"subj":"T978","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T979","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T980","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T981","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T982","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T983","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T984","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T985","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T986","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T987","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T988","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T989","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T990","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T991","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T992","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T993","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T994","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T995","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T996","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T997","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T998","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T999","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28163","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43635","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T8828","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T1098","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6321","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55209","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T36761","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98942","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T72211","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30799","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T11178","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T64611","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T23970","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T77931","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T3886","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T94309","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20019","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T27779","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T75315","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T94094","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55582","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T20788","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1281","span":{"begin":26,"end":30},"obj":"Gene"},{"id":"1282","span":{"begin":86,"end":90},"obj":"Gene"},{"id":"1283","span":{"begin":726,"end":730},"obj":"Gene"},{"id":"1284","span":{"begin":3,"end":13},"obj":"Species"},{"id":"1285","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"1286","span":{"begin":241,"end":250},"obj":"Disease"},{"id":"1287","span":{"begin":798,"end":807},"obj":"Disease"}],"attributes":[{"id":"A1281","pred":"tao:has_database_id","subj":"1281","obj":"Gene:59272"},{"id":"A1282","pred":"tao:has_database_id","subj":"1282","obj":"Gene:59272"},{"id":"A1283","pred":"tao:has_database_id","subj":"1283","obj":"Gene:59272"},{"id":"A1284","pred":"tao:has_database_id","subj":"1284","obj":"Tax:2697049"},{"id":"A1285","pred":"tao:has_database_id","subj":"1285","obj":"MESH:D007239"},{"id":"A1286","pred":"tao:has_database_id","subj":"1286","obj":"MESH:D007239"},{"id":"A1287","pred":"tao:has_database_id","subj":"1287","obj":"MESH:D007239"},{"subj":"1281","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1282","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1283","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1284","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1285","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1286","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1287","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32305401-25720466-55252996","span":{"begin":332,"end":334},"obj":"25720466"},{"id":"32305401-25720466-55252997","span":{"begin":471,"end":473},"obj":"25720466"},{"id":"32305401-25720466-55252998","span":{"begin":649,"end":651},"obj":"25720466"}],"attributes":[{"subj":"32305401-25720466-55252996","pred":"source","obj":"2_test"},{"subj":"32305401-25720466-55252997","pred":"source","obj":"2_test"},{"subj":"32305401-25720466-55252998","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9393ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#acec93"},{"id":"LitCovid-PD-CLO","color":"#ec93c6"},{"id":"LitCovid-PD-CHEBI","color":"#93e0ec"},{"id":"LitCovid-PD-GO-BP","color":"#ecde93"},{"id":"LitCovid-sentences","color":"#c493ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ecaa"},{"id":"LitCovid-PubTator","color":"#ec9396"},{"id":"2_test","color":"#93b0ec"}]}]}}