PMC:7161517 / 29803-30611 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T179","span":{"begin":119,"end":123},"obj":"Body_part"},{"id":"T180","span":{"begin":171,"end":179},"obj":"Body_part"},{"id":"T181","span":{"begin":206,"end":219},"obj":"Body_part"},{"id":"T182","span":{"begin":206,"end":210},"obj":"Body_part"},{"id":"T183","span":{"begin":266,"end":271},"obj":"Body_part"},{"id":"T184","span":{"begin":365,"end":370},"obj":"Body_part"}],"attributes":[{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T159","span":{"begin":3,"end":11},"obj":"Disease"},{"id":"T160","span":{"begin":241,"end":250},"obj":"Disease"},{"id":"T161","span":{"begin":798,"end":807},"obj":"Disease"}],"attributes":[{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T281","span":{"begin":119,"end":123},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T282","span":{"begin":206,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T283","span":{"begin":211,"end":219},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T284","span":{"begin":266,"end":271},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T285","span":{"begin":350,"end":370},"obj":"http://purl.obolibrary.org/obo/CL_0000228"},{"id":"T286","span":{"begin":387,"end":392},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T287","span":{"begin":444,"end":449},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T288","span":{"begin":604,"end":609},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T322","span":{"begin":171,"end":179},"obj":"Chemical"}],"attributes":[{"id":"A322","pred":"chebi_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T78","span":{"begin":155,"end":168},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T79","span":{"begin":294,"end":303},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T80","span":{"begin":337,"end":346},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T81","span":{"begin":513,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T82","span":{"begin":537,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0019068"},{"id":"T83","span":{"begin":637,"end":647},"obj":"http://purl.obolibrary.org/obo/GO_0006887"},{"id":"T84","span":{"begin":677,"end":692},"obj":"http://purl.obolibrary.org/obo/GO_0019068"},{"id":"T85","span":{"begin":697,"end":707},"obj":"http://purl.obolibrary.org/obo/GO_0006887"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T182","span":{"begin":0,"end":336},"obj":"Sentence"},{"id":"T183","span":{"begin":337,"end":475},"obj":"Sentence"},{"id":"T184","span":{"begin":476,"end":653},"obj":"Sentence"},{"id":"T185","span":{"begin":654,"end":808},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T978","span":{"begin":3,"end":13},"obj":"SP_7"},{"id":"T979","span":{"begin":26,"end":30},"obj":"G_3;PG_10;PR:000003622"},{"id":"T980","span":{"begin":86,"end":90},"obj":"G_3;PG_10;PR:000003622"},{"id":"T981","span":{"begin":91,"end":102},"obj":"SO:0000243"},{"id":"T982","span":{"begin":201,"end":219},"obj":"GO:0033644"},{"id":"T983","span":{"begin":307,"end":321},"obj":"GO:0005634"},{"id":"T984","span":{"begin":337,"end":349},"obj":"GO:0048468"},{"id":"T985","span":{"begin":350,"end":364},"obj":"GO:0005634;CL:0000228"},{"id":"T986","span":{"begin":365,"end":370},"obj":"CL:0000228"},{"id":"T987","span":{"begin":387,"end":392},"obj":"NCBITaxon:10239"},{"id":"T988","span":{"begin":444,"end":449},"obj":"NCBITaxon:10239"},{"id":"T989","span":{"begin":459,"end":469},"obj":"GO:0042571"},{"id":"T990","span":{"begin":497,"end":508},"obj":"GO:0006260"},{"id":"T991","span":{"begin":537,"end":543},"obj":"GO:0019012;GO:0019068"},{"id":"T992","span":{"begin":544,"end":552},"obj":"GO:0019068"},{"id":"T993","span":{"begin":560,"end":565},"obj":"GO:0005794"},{"id":"T994","span":{"begin":604,"end":609},"obj":"NCBITaxon:10239"},{"id":"T995","span":{"begin":613,"end":621},"obj":"GO:0031982"},{"id":"T996","span":{"begin":637,"end":647},"obj":"GO:0006887"},{"id":"T997","span":{"begin":677,"end":692},"obj":"GO:0019068"},{"id":"T998","span":{"begin":697,"end":707},"obj":"GO:0006887"},{"id":"T999","span":{"begin":726,"end":730},"obj":"G_3;PG_10;PR:000003622"},{"id":"T28163","span":{"begin":3,"end":13},"obj":"SP_7"},{"id":"T43635","span":{"begin":26,"end":30},"obj":"G_3;PG_10;PR:000003622"},{"id":"T8828","span":{"begin":86,"end":90},"obj":"G_3;PG_10;PR:000003622"},{"id":"T1098","span":{"begin":91,"end":102},"obj":"SO:0000243"},{"id":"T6321","span":{"begin":201,"end":219},"obj":"GO:0033644"},{"id":"T55209","span":{"begin":307,"end":321},"obj":"GO:0005634"},{"id":"T36761","span":{"begin":337,"end":349},"obj":"GO:0048468"},{"id":"T98942","span":{"begin":350,"end":364},"obj":"GO:0005634;CL:0000228"},{"id":"T72211","span":{"begin":365,"end":370},"obj":"CL:0000228"},{"id":"T30799","span":{"begin":387,"end":392},"obj":"NCBITaxon:10239"},{"id":"T11178","span":{"begin":444,"end":449},"obj":"NCBITaxon:10239"},{"id":"T64611","span":{"begin":459,"end":469},"obj":"GO:0042571"},{"id":"T23970","span":{"begin":497,"end":508},"obj":"GO:0006260"},{"id":"T77931","span":{"begin":537,"end":543},"obj":"GO:0019012;GO:0019068"},{"id":"T3886","span":{"begin":544,"end":552},"obj":"GO:0019068"},{"id":"T94309","span":{"begin":560,"end":565},"obj":"GO:0005794"},{"id":"T20019","span":{"begin":604,"end":609},"obj":"NCBITaxon:10239"},{"id":"T27779","span":{"begin":613,"end":621},"obj":"GO:0031982"},{"id":"T75315","span":{"begin":637,"end":647},"obj":"GO:0006887"},{"id":"T94094","span":{"begin":677,"end":692},"obj":"GO:0019068"},{"id":"T55582","span":{"begin":697,"end":707},"obj":"GO:0006887"},{"id":"T20788","span":{"begin":726,"end":730},"obj":"G_3;PG_10;PR:000003622"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1281","span":{"begin":26,"end":30},"obj":"Gene"},{"id":"1282","span":{"begin":86,"end":90},"obj":"Gene"},{"id":"1283","span":{"begin":726,"end":730},"obj":"Gene"},{"id":"1284","span":{"begin":3,"end":13},"obj":"Species"},{"id":"1285","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"1286","span":{"begin":241,"end":250},"obj":"Disease"},{"id":"1287","span":{"begin":798,"end":807},"obj":"Disease"}],"attributes":[{"id":"A1281","pred":"tao:has_database_id","subj":"1281","obj":"Gene:59272"},{"id":"A1282","pred":"tao:has_database_id","subj":"1282","obj":"Gene:59272"},{"id":"A1283","pred":"tao:has_database_id","subj":"1283","obj":"Gene:59272"},{"id":"A1284","pred":"tao:has_database_id","subj":"1284","obj":"Tax:2697049"},{"id":"A1285","pred":"tao:has_database_id","subj":"1285","obj":"MESH:D007239"},{"id":"A1286","pred":"tao:has_database_id","subj":"1286","obj":"MESH:D007239"},{"id":"A1287","pred":"tao:has_database_id","subj":"1287","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}

{"project":"2_test","denotations":[{"id":"32305401-25720466-55252996","span":{"begin":332,"end":334},"obj":"25720466"},{"id":"32305401-25720466-55252997","span":{"begin":471,"end":473},"obj":"25720466"},{"id":"32305401-25720466-55252998","span":{"begin":649,"end":651},"obj":"25720466"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66). Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66). Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66). In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection."}