PMC:7161517 / 1165-1612 JSONTXT

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SARS-CoV-2 requires binding to ACE2 in the RAS.\n• The ACE2/Ang1-7/Mas pathway counterbalances the RAS, which results in activation of anti-inflammatory pathways.\n• ACE inhibitors, ARBs, and MRAs upregulate ACE2 activity and expression.\n• More data are required to determine if regulation of ACE2 in patients with cardiovascular disease and COVID-19 would help improve clinical 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