PMC:7161517 / 1165-1612 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	uberon_id
T4	101-104	Body_part	denotes	RAS	http://purl.obolibrary.org/obo/UBERON_0018229
T5	157-160	Body_part	denotes	RAS	http://purl.obolibrary.org/obo/UBERON_0018229

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T11	3-11	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096
T12	58-66	Disease	denotes	SARS-CoV	http://purl.obolibrary.org/obo/MONDO_0005091
T13	374-396	Disease	denotes	cardiovascular disease	http://purl.obolibrary.org/obo/MONDO_0004995
T14	401-409	Disease	denotes	COVID-19	http://purl.obolibrary.org/obo/MONDO_0100096

Id	Subject	Object	Predicate	Lexical cue
T7	12-15	http://purl.obolibrary.org/obo/CLO_0051582	denotes	has
T8	179-189	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activation
T9	271-279	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T15	101-104	Chemical	denotes	RAS	http://purl.obolibrary.org/obo/CHEBI_63620
T16	157-160	Chemical	denotes	RAS	http://purl.obolibrary.org/obo/CHEBI_63620
T17	224-238	Chemical	denotes	ACE inhibitors	http://purl.obolibrary.org/obo/CHEBI_35457
T18	228-238	Chemical	denotes	inhibitors	http://purl.obolibrary.org/obo/CHEBI_35222

Id	Subject	Object	Predicate	Lexical cue
T1	338-348	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation

Id	Subject	Object	Predicate	Lexical cue
T10	0-57	Sentence	denotes	• COVID-19 has been associated with cardiac involvement.
T11	58-105	Sentence	denotes	SARS-CoV-2 requires binding to ACE2 in the RAS.
T12	106-220	Sentence	denotes	• The ACE2/Ang1-7/Mas pathway counterbalances the RAS, which results in activation of anti-inflammatory pathways.
T13	221-295	Sentence	denotes	• ACE inhibitors, ARBs, and MRAs upregulate ACE2 activity and expression.
T14	296-447	Sentence	denotes	• More data are required to determine if regulation of ACE2 in patients with cardiovascular disease and COVID-19 would help improve clinical outcomes.

Id	Subject	Object	Predicate	Lexical cue	hp_id
T2	374-396	Phenotype	denotes	cardiovascular disease	http://purl.obolibrary.org/obo/HP_0001626

Id	Subject	Object	Predicate	Lexical cue
T32	3-11	SP_7	denotes	COVID-19
T33	37-44	UBERON:0000948	denotes	cardiac
T34	58-68	SP_7	denotes	SARS-CoV-2
T35	89-93	G_3;PG_10;PR:000003622	denotes	ACE2
T36	113-117	G_3;PG_10;PR:000003622	denotes	ACE2
T37	118-122	PR:000036013	denotes	Ang1
T38	228-238	CHEBI:35222;CHEBI:35222	denotes	inhibitors
T39	266-270	G_3;PG_10;PR:000003622	denotes	ACE2
T40	284-294	GO:0010467	denotes	expression
T41	338-348	GO:0065007	denotes	regulation
T42	352-356	G_3;PG_10;PR:000003622	denotes	ACE2
T43	374-388	UBERON:0004535	denotes	cardiovascular
T44	401-409	SP_7	denotes	COVID-19
T15393	3-11	SP_7	denotes	COVID-19
T97887	37-44	UBERON:0000948	denotes	cardiac
T56833	58-68	SP_7	denotes	SARS-CoV-2
T99319	89-93	G_3;PG_10;PR:000003622	denotes	ACE2
T59141	113-117	G_3;PG_10;PR:000003622	denotes	ACE2
T38767	118-122	PR:000036013	denotes	Ang1
T18838	228-238	CHEBI:35222;CHEBI:35222	denotes	inhibitors
T45066	266-270	G_3;PG_10;PR:000003622	denotes	ACE2
T55988	284-294	GO:0010467	denotes	expression
T19730	338-348	GO:0065007	denotes	regulation
T92247	352-356	G_3;PG_10;PR:000003622	denotes	ACE2
T73655	374-388	UBERON:0004535	denotes	cardiovascular
T52119	401-409	SP_7	denotes	COVID-19

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
44	89-93	Gene	denotes	ACE2	Gene:59272
45	58-68	Species	denotes	SARS-CoV-2	Tax:2697049
46	3-11	Disease	denotes	COVID-19	MESH:C000657245
47	37-56	Disease	denotes	cardiac involvement	MESH:D006331
50	113-117	Gene	denotes	ACE2	Gene:59272
51	118-124	Gene	denotes	Ang1-7	Gene:284
54	224-227	Gene	denotes	ACE	Gene:1636
55	266-270	Gene	denotes	ACE2	Gene:59272
60	352-356	Gene	denotes	ACE2	Gene:59272
61	360-368	Species	denotes	patients	Tax:9606
62	374-396	Disease	denotes	cardiovascular disease	MESH:D002318
63	401-409	Disease	denotes	COVID-19	MESH:C000657245