PMC:7160614 / 14329-18413 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7160614","sourcedb":"PMC","sourceid":"7160614","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7160614","text":"The differences between patients with and without COVID-19 for all 67 features (41 imaging and 26 critical clinical features) are shown in Tables 1 and 2 and the Supplementary Materials (Tables E3 and E4). The differences between the primary cohort and validation cohort for the same features are shown in the Supplementary Materials (Tables E5 and E6). All characteristics except fatigue and white blood cell count in the CR model presented no significant difference between the primary and validation cohorts. A total of 1745 lesions were identified, with 1062 from the COVID-19 group and 683 from the non-COVID-19 group.\nTable 1 Radiological semantic features of patients in COVID-19 and non-COVID-19\nFeature Non-COVID-19 (n = 66) COVID-19 (n = 70) p value\nNumber of pure GGO\n  Total# 1.00 (0.00, 5.05) 3.50 (0.95, 8.05) 0.018b*\n  Peripheral area# 1.00 (0.00, 4.05) 2.00 (0.00, 6.05) 0.032b*\n  Central/both peripheral and central area# 0.00 (0.00, 0.00) 0.00 (0.00, 2.00) 0.001b*\nNumber of mixed GGO\n  Total# 1.00 (0.00, 3.05) 3.00 (1.00, 9.00) 0.001b*\n  Peripheral area# 0.00 (0.00, 2.00) 2.50 (1.00, 6.00) \u003c 0.001b*\n  Central/both peripheral and central area# 0.00 (0.00, 1.05) 0.00 (0.00, 2.00) 0.657b\nTotal number of consolidation\n  Consolidation# 1.00 (0.00, 3.00) 0.00 (0.00, 0.05) 0.001b*\n  Pure solid nodules# 0.00 (0.00, 0.00) 0.00 (0.00, 0.00) 0.309b\n  Solid nodules with GGO# 0.00 (0.00, 0.00) 0.00 (0.00, 1.00) 0.033b*\nTotal number of lesions\n  Peripheral area# 5.00 (2.00, 9.05) 7.00 (2.00, 13.00) 0.112b\n  Central area# 0.00 (0.00, 3.00) 0.00 (0.00, 1.05) 0.960b\n  Both peripheral and central area# 0.00 (0.00, 2.00) 0.00 (0.00, 2.05) 0.582b\nInterlobular septal thickening 0.009a*\n  Negative 44 (66.67%) 31 (44.29%)\n  Positive 22 (33.33%) 39 (55.71%)\nCrazy paving pattern \u003c 0.001a*\n  Negative 60 (90.91%) 32 (45.71%)\n  Positive 6 (9.09%) 38 (54.29%)\nTree-in-bud sign \u003c 0.001a*\n  Negative 37 (56.06%) 61 (87.14%)\n  Positive 29 (43.94%) 9 (12.86%)\nPleural thickening 0.030a*\n  Negative 46 (69.70%) 36 (51.43%)\n  Positive 20 (30.30%) 34 (48.57%)\nOffending vessel augmentation in lesions \u003c 0.001a*\n  Negative 55 (83.33%) 17 (24.29%)\n  Positive 11 (16.67%) 53 (75.71%)\nGGO ground-glass opacities\n#Results are median with interquartile range in parentheses, and the remainder results are measurements with corresponding ratio in parentheses\n*Data with statistical significance. pa: chi-square test, pb: Student’s t test\nTable 2 Clinical features of patients in COVID-19 and non-COVID-19\nFeature Non-COVID-19 (n = 66) COVID-19 (n = 70) p value\nSex\n  Male# 43 (65.15%) 41 (58.57%) 0.430a\n  Female# 23 (34.85%) 29 (41.43%)\n  Age (years) 46.73 ± 25.00 42.93 ± 13.32 0.275b\nVital signs\n  Systolic blood pressure (mmHg) 126.92 ± 23.07 127.07 ± 15.16 0.965b\n  Diastolic blood pressure (mmHg) 77.74 ± 15.72 80.39 ± 10.51 0.254b\n  Respiration rate (bpm) 25.20 ± 7.29 19.86 ± 1.90 \u003c 0.001b*\n  Heart rate (bpm) 101.59 ± 20.36 86.06 ± 13.34 \u003c 0.001b*\n  Temperature (°C) 37.61 ± 1.06 37.12 ± 0.83 0.003b*\nSigns\n  Dry cough# 56 (84.85%) 48 (68.57%) 0.025a*\n  Fatigue# 8 (12.12%) 22 (31.43%) 0.007a*\n  Sore throat# 6 (9.09%) 9 (12.86%) 0.483a\n  Stuffy# 4 (6.06%) 2 (2.86%) 0.623a\n  Runny nose# 3 (4.55%) 3 (4.29%) 0.731a\nWhite blood cell count (× 109/L) 11.48 ± 5.36 5.27 ± 2.33 \u003c 0.001b*\nWhite blood cell count category \u003c 0.001c*\n  Low# 0 (0.00%) 2 (2.86%)\n  Normal# 27 (40.91%) 63 (90.00%)\n  High# 39 (59.09%) 5 (7.14%)\nLymphocyte count (× 109/L) 1.57 ± 1.33 1.25 ± 0.68 0.086b\nLymphocyte count category \u003c 0.001c*\n  Low# 24 (36.36%) 32 (45.71%)\n  Normal# 35 (53.03%) 37 (52.86%)\n  High# 7 (10.61%) 1 (1.43%)\nNeutrophil count (× 109/L) 8.97 ± 4.90 3.53 ± 2.17 \u003c 0.001b*\nNeutrophil count category \u003c 0.001c*\n  Low# 3 (4.55%) 8 (11.43%)\n  Normal# 23 (34.85%) 59 (84.29%)\n  High# 40 (60.61%) 3 (4.29%)\nC-reactive protein (mg/L) 69.30 ± 65.88 26.37 ± 30.97 \u003c 0.001b*\nProcalcitonin (ng/mL) 3.36 ± 8.98 0.26 ± 0.84 0.007b*\n*Data with statistical significance. pa: chi-square test, pb: Student’s t test. pc: Kruskal-Wallis H test\n#Results are measurements with corresponding ratio in 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