PMC:7156805 / 4576-6298 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7156805","sourcedb":"PMC","sourceid":"7156805","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7156805","text":"Table I Considerations for commonly used immunomodulators and immunosuppressants for dermatologic conditions\nDrug class Mechanism of action Drug name Risk Comments/considerations∗\nClassic immunosuppressants\nInhibits NF-κB Corticosteroids Likely concerning risk Consider stopping when viral symptoms present especially with known or potential exposure\nCalcineurin inhibitor Tacrolimus\nCyclosporine\n Antimetabolites Inhibits DNA replication Mycophenolate mofetil\nAzathioprine\nMethotrexate\nImmunomodulators\n Monoclonal antibodies TNF-α inhibition Infliximab Likely moderate risk Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops\n Receptor fusion protein Etanercept\n Monoclonal antibodies Certolizumab\n Monoclonal antibodies Adalimumab\n IL receptor modulators IL inhibition Anakinra (IL-1)\n Monoclonal antibodies Dupilumab (IL-4) Likely low risk Continue unless severe symptoms present\n Monoclonal antibodies Brodalumab (IL-17) Likely moderate risk Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops\n Monoclonal antibodies Secukinumab (IL-17a)\n Monoclonal antibodies Ixekizumab (IL-17a)\n Monoclonal antibodies Ustekinumab (IL-12/23)\n Monoclonal antibodies Guselkumab (IL-23)\n Monoclonal antibodies Anti-CD20 antibody Rituximab Likely concerning risk Consider stopping when viral symptoms present especially with known or potential exposure.\nPDE4 inhibition Apremilast Likely low risk Continue unless severe symptoms present\nIL, Interleukin; NF-κB, nuclear factor κB; PDE4, phosphodiesterase 4.\n∗ General considerations only, medication use should be considered based on each individual patient's risk and disease 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