PMC:7156805 / 4576-6298
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
95 | 216-221 | Gene | denotes | NF-κB | Gene:4790 |
96 | 527-532 | Gene | denotes | TNF-α | Gene:7124 |
97 | 833-837 | Gene | denotes | IL-1 | Gene:3552 |
98 | 873-877 | Gene | denotes | IL-4 | Gene:3565 |
99 | 970-975 | Gene | denotes | IL-17 | Gene:3605 |
100 | 1137-1143 | Gene | denotes | IL-17a | Gene:3605 |
101 | 1180-1186 | Gene | denotes | IL-17a | Gene:3605 |
102 | 1269-1274 | Gene | denotes | IL-23 | Gene:51561 |
103 | 1442-1446 | Gene | denotes | PDE4 | Gene:5141 |
104 | 664-669 | Disease | denotes | fever | MESH:D005334 |
105 | 1086-1091 | Disease | denotes | fever | MESH:D005334 |
108 | 1568-1572 | Gene | denotes | PDE4 | Gene:5141 |
109 | 1542-1547 | Gene | denotes | NF-κB | Gene:4790 |
111 | 1687-1694 | Species | denotes | patient | Tax:9606 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T71 | 423-426 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
T72 | 696-703 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T73 | 786-788 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T74 | 809-811 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T75 | 833-837 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
T76 | 833-835 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T77 | 873-875 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T78 | 970-972 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T79 | 1137-1139 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T80 | 1180-1182 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T81 | 1224-1229 | Body_part | denotes | IL-12 | http://purl.org/sig/ont/fma/fma86579 |
T82 | 1224-1226 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T83 | 1269-1271 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T84 | 1309-1317 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T85 | 1525-1527 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T86 | 1529-1540 | Body_part | denotes | Interleukin | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T48 | 220-221 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T49 | 1546-1547 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T50 | 1565-1566 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T32 | 41-57 | Chemical | denotes | immunomodulators | http://purl.obolibrary.org/obo/CHEBI_50846 |
T33 | 216-218 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
T36 | 363-372 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T37 | 373-383 | Chemical | denotes | Tacrolimus | http://purl.obolibrary.org/obo/CHEBI_61049 |
T38 | 384-396 | Chemical | denotes | Cyclosporine | http://purl.obolibrary.org/obo/CHEBI_4031 |
T39 | 423-426 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
T40 | 439-452 | Chemical | denotes | Mycophenolate | http://purl.obolibrary.org/obo/CHEBI_168396 |
T41 | 474-486 | Chemical | denotes | Methotrexate | http://purl.obolibrary.org/obo/CHEBI_44185 |
T42 | 696-703 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T43 | 704-714 | Chemical | denotes | Etanercept | http://purl.obolibrary.org/obo/CHEBI_4875 |
T44 | 786-788 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T46 | 789-808 | Chemical | denotes | receptor modulators | http://purl.obolibrary.org/obo/CHEBI_90710 |
T47 | 809-811 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T49 | 833-835 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T51 | 873-875 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T53 | 970-972 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T55 | 1137-1139 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T57 | 1180-1182 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T59 | 1224-1226 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T61 | 1269-1271 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T63 | 1525-1527 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T65 | 1542-1544 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T28 | 351-362 | http://purl.obolibrary.org/obo/GO_0004723 | denotes | Calcineurin |
T29 | 351-362 | http://purl.obolibrary.org/obo/GO_0004722 | denotes | Calcineurin |
T30 | 414-438 | http://purl.obolibrary.org/obo/GO_0008156 | denotes | Inhibits DNA replication |
T31 | 423-438 | http://purl.obolibrary.org/obo/GO_0006260 | denotes | DNA replication |
T32 | 786-797 | http://purl.obolibrary.org/obo/GO_0004896 | denotes | IL receptor |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T10 | 664-669 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
T11 | 1086-1091 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T19 | 0-108 | Sentence | denotes | Table I Considerations for commonly used immunomodulators and immunosuppressants for dermatologic conditions |
T20 | 109-179 | Sentence | denotes | Drug class Mechanism of action Drug name Risk Comments/considerations∗ |
T21 | 180-206 | Sentence | denotes | Classic immunosuppressants |
T22 | 207-350 | Sentence | denotes | Inhibits NF-κB Corticosteroids Likely concerning risk Consider stopping when viral symptoms present especially with known or potential exposure |
T23 | 351-383 | Sentence | denotes | Calcineurin inhibitor Tacrolimus |
T24 | 384-396 | Sentence | denotes | Cyclosporine |
T25 | 397-460 | Sentence | denotes | Antimetabolites Inhibits DNA replication Mycophenolate mofetil |
T26 | 461-473 | Sentence | denotes | Azathioprine |
T27 | 474-486 | Sentence | denotes | Methotrexate |
T28 | 487-503 | Sentence | denotes | Immunomodulators |
T29 | 504-678 | Sentence | denotes | Monoclonal antibodies TNF-α inhibition Infliximab Likely moderate risk Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops |
T30 | 679-714 | Sentence | denotes | Receptor fusion protein Etanercept |
T31 | 715-750 | Sentence | denotes | Monoclonal antibodies Certolizumab |
T32 | 751-784 | Sentence | denotes | Monoclonal antibodies Adalimumab |
T33 | 785-838 | Sentence | denotes | IL receptor modulators IL inhibition Anakinra (IL-1) |
T34 | 839-934 | Sentence | denotes | Monoclonal antibodies Dupilumab (IL-4) Likely low risk Continue unless severe symptoms present |
T35 | 935-1100 | Sentence | denotes | Monoclonal antibodies Brodalumab (IL-17) Likely moderate risk Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops |
T36 | 1101-1144 | Sentence | denotes | Monoclonal antibodies Secukinumab (IL-17a) |
T37 | 1145-1187 | Sentence | denotes | Monoclonal antibodies Ixekizumab (IL-17a) |
T38 | 1188-1233 | Sentence | denotes | Monoclonal antibodies Ustekinumab (IL-12/23) |
T39 | 1234-1275 | Sentence | denotes | Monoclonal antibodies Guselkumab (IL-23) |
T40 | 1276-1441 | Sentence | denotes | Monoclonal antibodies Anti-CD20 antibody Rituximab Likely concerning risk Consider stopping when viral symptoms present especially with known or potential exposure. |
T41 | 1442-1524 | Sentence | denotes | PDE4 inhibition Apremilast Likely low risk Continue unless severe symptoms present |
T42 | 1525-1594 | Sentence | denotes | IL, Interleukin; NF-κB, nuclear factor κB; PDE4, phosphodiesterase 4. |
T43 | 1595-1722 | Sentence | denotes | ∗ General considerations only, medication use should be considered based on each individual patient's risk and disease profile. |