PMC:7144273 / 28205-29259 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7144273","sourcedb":"PMC","sourceid":"7144273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7144273","text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. 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