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LitCovid-PMC-OGER-BB

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T273","span":{"begin":501,"end":506},"obj":"Body_part"},{"id":"T274","span":{"begin":547,"end":557},"obj":"Body_part"},{"id":"T275","span":{"begin":562,"end":570},"obj":"Body_part"},{"id":"T276","span":{"begin":593,"end":601},"obj":"Body_part"},{"id":"T277","span":{"begin":602,"end":614},"obj":"Body_part"},{"id":"T278","span":{"begin":635,"end":646},"obj":"Body_part"},{"id":"T279","span":{"begin":650,"end":658},"obj":"Body_part"},{"id":"T280","span":{"begin":776,"end":780},"obj":"Body_part"}],"attributes":[{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma86301"},{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A279","pred":"fma_id","subj":"T279","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A280","pred":"fma_id","subj":"T280","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T212","span":{"begin":107,"end":128},"obj":"Disease"},{"id":"T213","span":{"begin":119,"end":128},"obj":"Disease"},{"id":"T214","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T215","span":{"begin":185,"end":189},"obj":"Disease"},{"id":"T216","span":{"begin":302,"end":311},"obj":"Disease"},{"id":"T217","span":{"begin":363,"end":380},"obj":"Disease"},{"id":"T218","span":{"begin":451,"end":459},"obj":"Disease"},{"id":"T219","span":{"begin":451,"end":455},"obj":"Disease"},{"id":"T220","span":{"begin":532,"end":541},"obj":"Disease"},{"id":"T221","span":{"begin":801,"end":809},"obj":"Disease"},{"id":"T222","span":{"begin":851,"end":859},"obj":"Disease"},{"id":"T223","span":{"begin":851,"end":855},"obj":"Disease"}],"attributes":[{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A216","pred":"mondo_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A217","pred":"mondo_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A218","pred":"mondo_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A219","pred":"mondo_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A220","pred":"mondo_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A221","pred":"mondo_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A222","pred":"mondo_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A223","pred":"mondo_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T446","span":{"begin":171,"end":177},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T447","span":{"begin":236,"end":241},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T448","span":{"begin":242,"end":250},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9443"},{"id":"T449","span":{"begin":392,"end":398},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T450","span":{"begin":425,"end":430},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T451","span":{"begin":476,"end":481},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T452","span":{"begin":501,"end":506},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T453","span":{"begin":562,"end":570},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T454","span":{"begin":602,"end":614},"obj":"http://purl.obolibrary.org/obo/UBERON_0005169"},{"id":"T455","span":{"begin":667,"end":669},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T456","span":{"begin":742,"end":749},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T457","span":{"begin":776,"end":780},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T458","span":{"begin":821,"end":822},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T459","span":{"begin":827,"end":832},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T460","span":{"begin":833,"end":840},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9443"},{"id":"T461","span":{"begin":951,"end":957},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T462","span":{"begin":1009,"end":1010},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T84","span":{"begin":907,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T85","span":{"begin":907,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T41","span":{"begin":107,"end":128},"obj":"Phenotype"},{"id":"T42","span":{"begin":532,"end":541},"obj":"Phenotype"}],"attributes":[{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

MyTest

{"project":"MyTest","denotations":[{"id":"32265310-20386712-29390480","span":{"begin":400,"end":402},"obj":"20386712"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

2_test

{"project":"2_test","denotations":[{"id":"32265310-20386712-29390480","span":{"begin":400,"end":402},"obj":"20386712"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T125","span":{"begin":0,"end":184},"obj":"Sentence"},{"id":"T126","span":{"begin":185,"end":404},"obj":"Sentence"},{"id":"T127","span":{"begin":405,"end":671},"obj":"Sentence"},{"id":"T128","span":{"begin":672,"end":810},"obj":"Sentence"},{"id":"T129","span":{"begin":811,"end":1054},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"1003","span":{"begin":185,"end":195},"obj":"Species"},{"id":"1004","span":{"begin":236,"end":241},"obj":"Species"},{"id":"1005","span":{"begin":276,"end":280},"obj":"Species"},{"id":"1006","span":{"begin":392,"end":397},"obj":"Species"},{"id":"1008","span":{"begin":451,"end":461},"obj":"Species"},{"id":"1009","span":{"begin":827,"end":832},"obj":"Species"},{"id":"1010","span":{"begin":851,"end":861},"obj":"Species"},{"id":"1011","span":{"begin":951,"end":957},"obj":"Species"},{"id":"1012","span":{"begin":24,"end":32},"obj":"Species"},{"id":"1013","span":{"begin":345,"end":353},"obj":"Species"},{"id":"1014","span":{"begin":891,"end":899},"obj":"Species"},{"id":"1015","span":{"begin":95,"end":128},"obj":"Disease"},{"id":"1016","span":{"begin":302,"end":311},"obj":"Disease"},{"id":"1017","span":{"begin":363,"end":380},"obj":"Disease"},{"id":"1018","span":{"begin":437,"end":445},"obj":"Disease"},{"id":"1019","span":{"begin":532,"end":541},"obj":"Disease"},{"id":"1020","span":{"begin":801,"end":809},"obj":"Disease"},{"id":"1021","span":{"begin":985,"end":994},"obj":"Disease"}],"attributes":[{"id":"A1003","pred":"tao:has_database_id","subj":"1003","obj":"Tax:2697049"},{"id":"A1004","pred":"tao:has_database_id","subj":"1004","obj":"Tax:9606"},{"id":"A1005","pred":"tao:has_database_id","subj":"1005","obj":"Tax:10090"},{"id":"A1006","pred":"tao:has_database_id","subj":"1006","obj":"Tax:9606"},{"id":"A1008","pred":"tao:has_database_id","subj":"1008","obj":"Tax:2697049"},{"id":"A1009","pred":"tao:has_database_id","subj":"1009","obj":"Tax:9606"},{"id":"A1010","pred":"tao:has_database_id","subj":"1010","obj":"Tax:2697049"},{"id":"A1011","pred":"tao:has_database_id","subj":"1011","obj":"Tax:9606"},{"id":"A1012","pred":"tao:has_database_id","subj":"1012","obj":"Tax:191496"},{"id":"A1013","pred":"tao:has_database_id","subj":"1013","obj":"Tax:191496"},{"id":"A1014","pred":"tao:has_database_id","subj":"1014","obj":"Tax:191496"},{"id":"A1015","pred":"tao:has_database_id","subj":"1015","obj":"MESH:D018352"},{"id":"A1016","pred":"tao:has_database_id","subj":"1016","obj":"MESH:D007239"},{"id":"A1017","pred":"tao:has_database_id","subj":"1017","obj":"MESH:D008171"},{"id":"A1018","pred":"tao:has_database_id","subj":"1018","obj":"MESH:D007239"},{"id":"A1019","pred":"tao:has_database_id","subj":"1019","obj":"MESH:D011014"},{"id":"A1020","pred":"tao:has_database_id","subj":"1020","obj":"MESH:C000657245"},{"id":"A1021","pred":"tao:has_database_id","subj":"1021","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"There are as yet no pre-clinical data investigating effects of MSC administration in models of coronavirus respiratory infection, mostly due to the lack of an established animal model. SARS-CoV-2 replication was observed in several non-human primates and in inbred strains of mice following intranasal infection, but these models failed to show clinical signs of pulmonary disease as seen in humans [44]. Mice transgenic for human ACE2, infected with SARS-CoV-2, demonstrated virus replication in the lungs, as well as interstitial pneumonia with lymphocyte and monocyte infiltration into the alveolar interstitium and accumulation of macrophages in alveolar spaces [45]. While this model requires further evaluation, it might facilitate the testing of therapeutics including cell-based therapies for COVID-19. Recently, a non-human primate model for SARS-CoV-2 was able to reflect the same clinical signs, viral replication and pathology observed in humans, with comparable levels of mortality, and might be a valuable model for further evaluation [46]."}

PMC:7144273 / 28205-29259 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7144273 / 28205-29259 JSON TXT