PMC:7144273 / 12405-13390 JSONTXT

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2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

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{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T28","span":{"begin":116,"end":127},"obj":"Body_part"}],"attributes":[{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T102","span":{"begin":642,"end":645},"obj":"Disease"},{"id":"T103","span":{"begin":849,"end":852},"obj":"Disease"}],"attributes":[{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0004277"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0008538"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T147","span":{"begin":49,"end":53},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T148","span":{"begin":94,"end":99},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T149","span":{"begin":110,"end":115},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T150","span":{"begin":116,"end":120},"obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"id":"T151","span":{"begin":153,"end":168},"obj":"http://purl.obolibrary.org/obo/CL_0000499"},{"id":"T152","span":{"begin":170,"end":172},"obj":"http://purl.obolibrary.org/obo/CLO_0001997"},{"id":"T153","span":{"begin":179,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T154","span":{"begin":222,"end":235},"obj":"http://purl.obolibrary.org/obo/PR_000001091"},{"id":"T155","span":{"begin":329,"end":333},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T156","span":{"begin":357,"end":358},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T157","span":{"begin":377,"end":378},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T158","span":{"begin":757,"end":763},"obj":"http://purl.obolibrary.org/obo/PR_000025875"},{"id":"T159","span":{"begin":783,"end":789},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T160","span":{"begin":799,"end":801},"obj":"http://purl.obolibrary.org/obo/CLO_0051741"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

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{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36","span":{"begin":49,"end":64},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T37","span":{"begin":245,"end":253},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T38","span":{"begin":245,"end":253},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T39","span":{"begin":245,"end":253},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T40","span":{"begin":245,"end":253},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T41","span":{"begin":329,"end":344},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T42","span":{"begin":605,"end":615},"obj":"http://purl.obolibrary.org/obo/GO_0045158"},{"id":"T43","span":{"begin":605,"end":615},"obj":"http://purl.obolibrary.org/obo/GO_0045157"},{"id":"T44","span":{"begin":605,"end":615},"obj":"http://purl.obolibrary.org/obo/GO_0045156"},{"id":"T45","span":{"begin":605,"end":615},"obj":"http://purl.obolibrary.org/obo/GO_0008121"},{"id":"T46","span":{"begin":683,"end":710},"obj":"http://purl.obolibrary.org/obo/GO_0008191"},{"id":"T47","span":{"begin":814,"end":818},"obj":"http://purl.obolibrary.org/obo/GO_0047291"},{"id":"T48","span":{"begin":828,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0006820"},{"id":"T49","span":{"begin":919,"end":930},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T19","span":{"begin":238,"end":244},"obj":"Phenotype"}],"attributes":[{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

{"project":"LitCovid-sentences","denotations":[{"id":"T60","span":{"begin":0,"end":328},"obj":"Sentence"},{"id":"T61","span":{"begin":329,"end":402},"obj":"Sentence"},{"id":"T62","span":{"begin":403,"end":973},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}

{"project":"LitCovid-PubTator","denotations":[{"id":"397","span":{"begin":683,"end":712},"obj":"Gene"},{"id":"404","span":{"begin":820,"end":847},"obj":"Gene"},{"id":"416","span":{"begin":940,"end":965},"obj":"Gene"},{"id":"426","span":{"begin":110,"end":115},"obj":"Species"},{"id":"428","span":{"begin":72,"end":82},"obj":"Gene"}],"attributes":[{"id":"A397","pred":"tao:has_database_id","subj":"397","obj":"Gene:7076"},{"id":"A404","pred":"tao:has_database_id","subj":"404","obj":"Gene:10861"},{"id":"A416","pred":"tao:has_database_id","subj":"416","obj":"Gene:4953"},{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"Tax:9606"},{"id":"A428","pred":"tao:has_database_id","subj":"428","obj":"Gene:3439"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"FIGURE 2 Representative volcano plot analysis of gene expression of the interferon-stimulated genes (ISGs) in human bone marrow-derived mesenchymal stem (stromal) cells (BM-MSCs) activated with pro-inflammatory cytokines (interleukin-1β, tumour necrosis factor-α and interferon (IFN)-γ), versus control, in GEO dataset GSE68610. Gene expression analysis of a) constitutive and b) non-constitutive ISGs. ISG15: ubiquitin-like protein; CCL2: C-C motif chemokine 2; IFI6: IFN-α-inducible protein 6; PMAIP1: phorbol-12-myristate-13-acetate-induced protein 1; IFITM: IFN-induced transmembrane protein; CYP1B1: cytochrome p450 1b1; NPAS2: neuronal PAS domain-containing protein 2; TIMP-1: metalloproteinase inhibitor 1; MT1G/MT1X: metallothionein 1G/X; SERPING1: serpin family G member 1 (plasma protease C1 inhibitor); SAT1: sulfate anion transporter 1; GCA: grancalcin; IFNAR2: IFN-α/β receptor 2; SLC16A1: monocarboxylate transporter 1; ODC1: ornithine decarboxylase 1; FZD-5: Frizzled-5."}