PMC:7143804 / 6685-8195
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 76 | 596-616 | Chemical | denotes | polydimethylsiloxane | MESH:C013830 |
| 77 | 618-622 | Chemical | denotes | PDMS | MESH:C013830 |
| 78 | 1033-1056 | Chemical | denotes | cyclic olefin copolymer | |
| 79 | 1058-1061 | Chemical | denotes | COC |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T18 | 84-87 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T19 | 91-94 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 999-1004 | Body_part | denotes | scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T49 | 65-66 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T50 | 72-79 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
| T51 | 142-145 | http://purl.obolibrary.org/obo/CLO_0050884 | denotes | ten |
| T52 | 232-239 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
| T53 | 273-274 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T54 | 717-718 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T55 | 917-919 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T56 | 1234-1241 | http://purl.obolibrary.org/obo/OBI_0000968 | denotes | devices |
| T57 | 1318-1320 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T58 | 1415-1416 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T59 | 1506-1508 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T28 | 84-87 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T29 | 91-94 | Chemical | denotes | RNA | http://purl.obolibrary.org/obo/CHEBI_33697 |
| T30 | 146-154 | Chemical | denotes | polymers | http://purl.obolibrary.org/obo/CHEBI_33839 |
| T31 | 179-185 | Chemical | denotes | metals | http://purl.obolibrary.org/obo/CHEBI_33521 |
| T32 | 596-616 | Chemical | denotes | polydimethylsiloxane | http://purl.obolibrary.org/obo/CHEBI_31498|http://purl.obolibrary.org/obo/CHEBI_48137|http://purl.obolibrary.org/obo/CHEBI_61466|http://purl.obolibrary.org/obo/CHEBI_61468 |
| T36 | 618-622 | Chemical | denotes | PDMS | http://purl.obolibrary.org/obo/CHEBI_31498|http://purl.obolibrary.org/obo/CHEBI_61468 |
| T38 | 1033-1046 | Chemical | denotes | cyclic olefin | http://purl.obolibrary.org/obo/CHEBI_33642 |
| T39 | 1040-1046 | Chemical | denotes | olefin | http://purl.obolibrary.org/obo/CHEBI_32878|http://purl.obolibrary.org/obo/CHEBI_33641 |
| T41 | 1047-1056 | Chemical | denotes | copolymer | http://purl.obolibrary.org/obo/CHEBI_53310|http://purl.obolibrary.org/obo/CHEBI_60804 |
| T43 | 1058-1061 | Chemical | denotes | COC | http://purl.obolibrary.org/obo/CHEBI_53310 |
| T44 | 1342-1345 | Chemical | denotes | COC | http://purl.obolibrary.org/obo/CHEBI_53310 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T58 | 0-109 | Sentence | denotes | There are various materials that can be used to fabricate lab-on-a-chip devices for DNA or RNA amplification. |
| T59 | 110-245 | Sentence | denotes | In the past 15 years, more than ten polymers, ceramic materials, and metals have successfully been used to fabricate such devices [15]. |
| T60 | 246-325 | Sentence | denotes | The major property playing a role here is the biocompatibility of the material. |
| T61 | 326-414 | Sentence | denotes | The surface of the microfluidic structure should not inhibit the amplification reaction. |
| T62 | 415-568 | Sentence | denotes | This biocompatibility can be an intrinsic property of the material or the surface can be modified or coated to achieve this [12,13,14,15,16,17,18,19,20]. |
| T63 | 569-699 | Sentence | denotes | One often used material is polydimethylsiloxane (PDMS) [22,23,31,32,34,35,38], which can be processed using soft lithography [39]. |
| T64 | 700-817 | Sentence | denotes | However, this is a fabrication technology used in academia and is not suitable for upscaling to mass production [40]. |
| T65 | 818-921 | Sentence | denotes | Fabrication methods suitable for mass production are thermoforming/embossing or injection molding [41]. |
| T66 | 922-1141 | Sentence | denotes | One of the materials which is biocompatible and suitable for both industrial scale fabrication technologies is cyclic olefin copolymer (COC) [42], which is one of the materials used in the past as well [28,36,43,44,45]. |
| T67 | 1142-1322 | Sentence | denotes | Guckenberger et al. estimates the costs of injection molding of only 50 simple microfluidic devices on $47, but this becomes cheaper when the mass production stage is reached [41]. |
| T68 | 1323-1396 | Sentence | denotes | Another benefit of COC is the possibility to shape it using micromilling. |
| T69 | 1397-1510 | Sentence | denotes | This technique is a rapid prototyping technology and therefore very useful within proof-of-concept projects [41]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32106462-19327449-69893292 | 241-243 | 19327449 | denotes | 15 |
| 32106462-24030680-69893293 | 540-542 | 24030680 | denotes | 12 |
| 32106462-19327449-69893294 | 549-551 | 19327449 | denotes | 15 |
| 32106462-21387067-69893295 | 555-557 | 21387067 | denotes | 17 |
| 32106462-17553097-69893296 | 558-560 | 17553097 | denotes | 18 |
| 32106462-22704369-69893297 | 564-566 | 22704369 | denotes | 20 |
| 32106462-21479543-69893298 | 625-627 | 21479543 | denotes | 22 |
| 32106462-23610705-69893299 | 628-630 | 23610705 | denotes | 23 |
| 32106462-18975094-69893300 | 637-639 | 18975094 | denotes | 34 |
| 32106462-20218572-69893301 | 643-645 | 20218572 | denotes | 38 |
| 32106462-28281349-69893302 | 813-815 | 28281349 | denotes | 40 |
| 32106462-25906246-69893303 | 917-919 | 25906246 | denotes | 41 |
| 32106462-20066496-69893304 | 1131-1133 | 20066496 | denotes | 43 |
| 32106462-31277382-69893305 | 1137-1139 | 31277382 | denotes | 45 |
| 32106462-25906246-69893306 | 1318-1320 | 25906246 | denotes | 41 |
| 32106462-25906246-69893307 | 1506-1508 | 25906246 | denotes | 41 |