PMC:7143804 / 6685-8195
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7143804","sourcedb":"PMC","sourceid":"7143804","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7143804","text":"There are various materials that can be used to fabricate lab-on-a-chip devices for DNA or RNA amplification. In the past 15 years, more than ten polymers, ceramic materials, and metals have successfully been used to fabricate such devices [15]. The major property playing a role here is the biocompatibility of the material. The surface of the microfluidic structure should not inhibit the amplification reaction. This biocompatibility can be an intrinsic property of the material or the surface can be modified or coated to achieve this [12,13,14,15,16,17,18,19,20]. One often used material is polydimethylsiloxane (PDMS) [22,23,31,32,34,35,38], which can be processed using soft lithography [39]. However, this is a fabrication technology used in academia and is not suitable for upscaling to mass production [40]. Fabrication methods suitable for mass production are thermoforming/embossing or injection molding [41]. One of the materials which is biocompatible and suitable for both industrial scale fabrication technologies is cyclic olefin copolymer (COC) [42], which is one of the materials used in the past as well [28,36,43,44,45]. Guckenberger et al. estimates the costs of injection molding of only 50 simple microfluidic devices on $47, but this becomes cheaper when the mass production stage is reached [41]. Another benefit of COC is the possibility to shape it using micromilling. This technique is a rapid prototyping technology and therefore very useful within proof-of-concept projects 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