PMC:7143804 / 27319-30599
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7143804","sourcedb":"PMC","sourceid":"7143804","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7143804","text":"3.1. COMSOL MultiPhysics Simulation Results\nIn Figure 5, the results of heat transfer simulations of two different heater spacings are shown. The heater width for both geometries is 0.3 mm, while the heater spacing in Figure 5b,c are 0.3 mm and 2.0 mm, respectively. In Figure 6a–d, tables with the results of the full parametric sweep for different heater widths and heater spacings are shown. Figure 6a shows the temperature deviation between the highest and lowest temperature at the top of the chamber, i.e., the second H2O and COC interface (ΔTtopofchamber=Ttop,max−Ttop,min). Figure 6b shows the deviation between the highest and lowest temperature inside the chamber, i.e., between the two COC and H2O interfaces (ΔTacrosschamber=Tbottom,max−Ttop,min). Figure 6c shows the temperature deviation between the highest and lowest temperature at the bottom of the chamber, i.e., the first COC and H2O interface (ΔTbottomofchamber=Tbot,max−Tbot,min). Figure 6d shows the deviation between the set heater temperature of 30 °C and the lowest temperature at the top of the chamber, i.e., the second H2O and COC interface (ΔTdeviationfromsetT=Theater−Ttop,min). As can be seen from the results in Figure 6, a combination of small heater widths and heater spacings will result in smaller temperature differences inside the reaction mixture. This is evident as smaller heater spacings will result in a better coverage of the heated area by heater material. The smaller heater widths will result in a smaller heater cross-sectional area, and thus can be operated at lower powers, as is evident from Equation (1). Resulting in the fact that a densely packed meander structure with small heater widths and small heater spacings can dissipate more heat into the system.\nBased on these results and its simplicity, a meandering heater pattern of a heater with a width of 0.3 mm and a spacing of 0.3 mm in between the lines is designed. A side note on the chosen heater width and heater spacing is that according to the simulations, the temperature differences within the chamber are less than ±0.3 °C for the most unfavorable dimensions. This temperature difference is still well-accepted in the temperature window in which the MDA reaction takes place (25 °C to 35 °C). However, as pointed out, a smaller cross-sectional area will result in a lower power consumption and therefore these dimensions are chosen. It is known that a meandering heater structure does not give the optimal temperature distribution over the device [26]. Therefore, the heater lines are longer than the width of the reaction chamber, and thus also covering the bulk material outside the chamber in order to improve the temperature uniformity inside the reaction mixture.\nThe heater pattern is divided over two shadow masks to minimize the length of the narrow Mo tracks in between the meandering structure. This prevents curvature due to intrinsic stresses. See Figure 7 for the outlines of both shadow masks, together with the resulting pattern on COC. The use of two shadow masks will give a metal track in which small parts has the double thickness. Here, the temperature will be lower. The system is designed such that these thicker parts are outside the reaction chamber and temperature control chamber 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