PMC:7128678 / 8439-9131 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"276","span":{"begin":267,"end":280},"obj":"Species"},{"id":"283","span":{"begin":95,"end":106},"obj":"Chemical"},{"id":"284","span":{"begin":116,"end":122},"obj":"Chemical"},{"id":"285","span":{"begin":310,"end":344},"obj":"Chemical"},{"id":"286","span":{"begin":477,"end":488},"obj":"Chemical"},{"id":"287","span":{"begin":616,"end":627},"obj":"Chemical"},{"id":"288","span":{"begin":641,"end":652},"obj":"Chemical"}],"attributes":[{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"Tax:11118"},{"id":"A285","pred":"tao:has_database_id","subj":"285","obj":"MESH:C025676"},{"id":"A286","pred":"tao:has_database_id","subj":"286","obj":"MESH:D019158"},{"id":"A288","pred":"tao:has_database_id","subj":"288","obj":"MESH:D019158"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T190","span":{"begin":116,"end":122},"obj":"PR:000002082"},{"id":"T191","span":{"begin":142,"end":150},"obj":"CHEBI:36916;CHEBI:36916"},{"id":"T192","span":{"begin":222,"end":229},"obj":"GO:0032991"},{"id":"T193","span":{"begin":267,"end":280},"obj":"NCBITaxon:11118"},{"id":"T194","span":{"begin":310,"end":311},"obj":"CHEBI:16066;CHEBI:16066"},{"id":"T195","span":{"begin":314,"end":320},"obj":"CHEBI:40574;CHEBI:40574"},{"id":"T196","span":{"begin":321,"end":344},"obj":"CHEBI:17012;CHEBI:17012"},{"id":"T197","span":{"begin":477,"end":488},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T198","span":{"begin":628,"end":633},"obj":"CHEBI:24433;CHEBI:24433"},{"id":"T199","span":{"begin":641,"end":652},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T200","span":{"begin":673,"end":687},"obj":"CHEBI:64766;CHEBI:64766"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T41","span":{"begin":321,"end":344},"obj":"Body_part"}],"attributes":[{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma82788"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T54","span":{"begin":13,"end":14},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T55","span":{"begin":15,"end":16},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T56","span":{"begin":377,"end":378},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":490,"end":491},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":545,"end":548},"obj":"http://purl.obolibrary.org/obo/CLO_0002755"},{"id":"T59","span":{"begin":585,"end":587},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T134","span":{"begin":107,"end":112},"obj":"Chemical"},{"id":"T135","span":{"begin":116,"end":122},"obj":"Chemical"},{"id":"T137","span":{"begin":314,"end":320},"obj":"Chemical"},{"id":"T139","span":{"begin":321,"end":344},"obj":"Chemical"},{"id":"T140","span":{"begin":340,"end":344},"obj":"Chemical"},{"id":"T141","span":{"begin":477,"end":488},"obj":"Chemical"},{"id":"T142","span":{"begin":484,"end":488},"obj":"Chemical"},{"id":"T143","span":{"begin":628,"end":633},"obj":"Chemical"},{"id":"T144","span":{"begin":641,"end":652},"obj":"Chemical"},{"id":"T145","span":{"begin":648,"end":652},"obj":"Chemical"},{"id":"T146","span":{"begin":673,"end":687},"obj":"Chemical"},{"id":"T147","span":{"begin":682,"end":687},"obj":"Chemical"}],"attributes":[{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A136","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A138","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_64766"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}

{"project":"LitCovid-sentences","denotations":[{"id":"T66","span":{"begin":19,"end":187},"obj":"Sentence"},{"id":"T67","span":{"begin":188,"end":263},"obj":"Sentence"},{"id":"T68","span":{"begin":264,"end":489},"obj":"Sentence"},{"id":"T69","span":{"begin":490,"end":597},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}

{"project":"2_test","denotations":[{"id":"32251731-23873408-48149952","span":{"begin":356,"end":358},"obj":"23873408"},{"id":"T46400","span":{"begin":356,"end":358},"obj":"23873408"}],"text":"ition Fig. 2(a,b). The interaction was driven by the positioning of the negative charge of the carboxylate group of Neu5Ac and one of the two cationic charges of CLQ (pKa 10.2) Fig. 2(c). The energy of interaction of this complex was estimated to be -47 kJ.mol−1. As coronaviruses preferentially interact with 9-O-acetyl-N-acetylneuraminic acid (9-O-SIA) [10], this study used a similar molecular modelling approach to assess whether CLQ could also interact with this specific sialic acid. A good fit between CLQ and 9-O-SIA was obtained Fig. 2(d–f), with an energy of interaction of -45 kJ.mol−1. In this case, the carboxylate group of the sialic acid interacted with the cationic group of t"}