PMC:7128678 / 31807-32488 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7128678","sourcedb":"PMC","sourceid":"7128678","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7128678","text":"5 Conclusion\nGiven the global health emergency, drug repurposing is obviously the option of choice [2,3]. However, a considerable amount of time could be saved by in-silico testing to determine the capability of any potential anti-SARS-CoV-2 to disrupt the interaction of the S protein with the host cell membrane. Applied to both RBD–ACE-2 and NTD–ganglioside interactions, this molecular modelling method will help select those drugs that are likely to interfere with the initial attachment of virus particles to the respiratory tract surface epithelium. The study data support the use of CLQ, and preferentially CLQ-OH, as initial therapy for patients infected with SARS-CoV-2.","divisions":[{"label":"label","span":{"begin":0,"end":1}},{"label":"title","span":{"begin":3,"end":13}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"996","span":{"begin":336,"end":341},"obj":"Gene"},{"id":"997","span":{"begin":277,"end":278},"obj":"Gene"},{"id":"998","span":{"begin":647,"end":655},"obj":"Species"},{"id":"999","span":{"begin":670,"end":680},"obj":"Species"},{"id":"1000","span":{"begin":232,"end":242},"obj":"Species"},{"id":"1001","span":{"begin":346,"end":361},"obj":"Chemical"},{"id":"1002","span":{"begin":616,"end":622},"obj":"Chemical"},{"id":"1003","span":{"begin":656,"end":664},"obj":"Disease"}],"attributes":[{"id":"A996","pred":"tao:has_database_id","subj":"996","obj":"Gene:59272"},{"id":"A997","pred":"tao:has_database_id","subj":"997","obj":"Gene:43740568"},{"id":"A998","pred":"tao:has_database_id","subj":"998","obj":"Tax:9606"},{"id":"A999","pred":"tao:has_database_id","subj":"999","obj":"Tax:2697049"},{"id":"A1000","pred":"tao:has_database_id","subj":"1000","obj":"Tax:2697049"},{"id":"A1003","pred":"tao:has_database_id","subj":"1003","obj":"MESH:D007239"},{"subj":"996","pred":"source","obj":"LitCovid-PubTator"},{"subj":"997","pred":"source","obj":"LitCovid-PubTator"},{"subj":"998","pred":"source","obj":"LitCovid-PubTator"},{"subj":"999","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1000","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1001","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1002","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1003","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T702","span":{"begin":49,"end":53},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T703","span":{"begin":232,"end":242},"obj":"SP_7"},{"id":"T704","span":{"begin":277,"end":286},"obj":"PG_1"},{"id":"T705","span":{"begin":296,"end":314},"obj":"GO:0033644"},{"id":"T706","span":{"begin":336,"end":341},"obj":"G_3;PG_10;PR:000003622"},{"id":"T707","span":{"begin":350,"end":361},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T708","span":{"begin":431,"end":436},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T709","span":{"begin":497,"end":502},"obj":"NCBITaxon:10239"},{"id":"T710","span":{"begin":520,"end":537},"obj":"UBERON:0000065"},{"id":"T711","span":{"begin":546,"end":556},"obj":"UBERON:0000483"},{"id":"T712","span":{"begin":670,"end":680},"obj":"SP_7"},{"id":"T76020","span":{"begin":49,"end":53},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T3558","span":{"begin":670,"end":680},"obj":"SP_7"}],"attributes":[{"subj":"T702","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T703","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T704","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T705","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T706","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T707","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T708","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T709","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T710","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T711","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T712","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T76020","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T3558","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T227","span":{"begin":279,"end":286},"obj":"Body_part"},{"id":"T228","span":{"begin":301,"end":314},"obj":"Body_part"},{"id":"T229","span":{"begin":301,"end":305},"obj":"Body_part"},{"id":"T230","span":{"begin":350,"end":361},"obj":"Body_part"},{"id":"T231","span":{"begin":520,"end":537},"obj":"Body_part"},{"id":"T232","span":{"begin":538,"end":556},"obj":"Body_part"},{"id":"T233","span":{"begin":546,"end":556},"obj":"Body_part"}],"attributes":[{"id":"A227","pred":"fma_id","subj":"T227","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A228","pred":"fma_id","subj":"T228","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A229","pred":"fma_id","subj":"T229","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma265130"},{"id":"A232","pred":"fma_id","subj":"T232","obj":"http://purl.org/sig/ont/fma/fma70997"},{"id":"A233","pred":"fma_id","subj":"T233","obj":"http://purl.org/sig/ont/fma/fma9639"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T23","span":{"begin":520,"end":537},"obj":"Body_part"},{"id":"T24","span":{"begin":538,"end":556},"obj":"Body_part"},{"id":"T25","span":{"begin":546,"end":556},"obj":"Body_part"}],"attributes":[{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0006677"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T151","span":{"begin":232,"end":240},"obj":"Disease"},{"id":"T152","span":{"begin":346,"end":349},"obj":"Disease"},{"id":"T154","span":{"begin":670,"end":678},"obj":"Disease"}],"attributes":[{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A153","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A154","pred":"mondo_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T266","span":{"begin":116,"end":117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T267","span":{"begin":174,"end":181},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T268","span":{"begin":301,"end":305},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T269","span":{"begin":306,"end":314},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T270","span":{"begin":497,"end":502},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T271","span":{"begin":546,"end":556},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"}],"attributes":[{"subj":"T266","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T736","span":{"begin":49,"end":53},"obj":"Chemical"},{"id":"T737","span":{"begin":279,"end":286},"obj":"Chemical"},{"id":"T738","span":{"begin":350,"end":361},"obj":"Chemical"},{"id":"T739","span":{"begin":431,"end":436},"obj":"Chemical"}],"attributes":[{"id":"A736","pred":"chebi_id","subj":"T736","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A737","pred":"chebi_id","subj":"T737","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A738","pred":"chebi_id","subj":"T738","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A739","pred":"chebi_id","subj":"T739","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T736","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T737","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T738","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T739","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T246","span":{"begin":0,"end":13},"obj":"Sentence"},{"id":"T247","span":{"begin":14,"end":106},"obj":"Sentence"},{"id":"T248","span":{"begin":107,"end":315},"obj":"Sentence"},{"id":"T249","span":{"begin":316,"end":557},"obj":"Sentence"},{"id":"T250","span":{"begin":558,"end":681},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T246","pred":"source","obj":"LitCovid-sentences"},{"subj":"T247","pred":"source","obj":"LitCovid-sentences"},{"subj":"T248","pred":"source","obj":"LitCovid-sentences"},{"subj":"T249","pred":"source","obj":"LitCovid-sentences"},{"subj":"T250","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32251731-22743966-48149964","span":{"begin":101,"end":102},"obj":"22743966"},{"id":"T86521","span":{"begin":101,"end":102},"obj":"22743966"}],"attributes":[{"subj":"32251731-22743966-48149964","pred":"source","obj":"2_test"},{"subj":"T86521","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#e9ec93","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#d493ec"},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecba"},{"id":"LitCovid-PD-UBERON","color":"#eca093"},{"id":"LitCovid-PD-MONDO","color":"#939fec"},{"id":"LitCovid-PD-CLO","color":"#b9ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93d3"},{"id":"LitCovid-sentences","color":"#93eceb"},{"id":"2_test","color":"#ecd193"}]}]}}