PMC:7128678 / 28796-29987 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"913","span":{"begin":99,"end":107},"obj":"Species"},{"id":"914","span":{"begin":122,"end":132},"obj":"Species"},{"id":"915","span":{"begin":944,"end":957},"obj":"Species"},{"id":"916","span":{"begin":234,"end":242},"obj":"Chemical"},{"id":"917","span":{"begin":344,"end":356},"obj":"Chemical"},{"id":"918","span":{"begin":361,"end":373},"obj":"Chemical"},{"id":"919","span":{"begin":496,"end":501},"obj":"Chemical"},{"id":"920","span":{"begin":634,"end":645},"obj":"Chemical"},{"id":"921","span":{"begin":766,"end":772},"obj":"Chemical"},{"id":"922","span":{"begin":836,"end":842},"obj":"Chemical"},{"id":"923","span":{"begin":859,"end":871},"obj":"Chemical"},{"id":"924","span":{"begin":996,"end":1002},"obj":"Chemical"},{"id":"925","span":{"begin":1016,"end":1027},"obj":"Chemical"},{"id":"926","span":{"begin":1039,"end":1051},"obj":"Chemical"},{"id":"927","span":{"begin":1107,"end":1118},"obj":"Chemical"},{"id":"928","span":{"begin":108,"end":116},"obj":"Disease"},{"id":"929","span":{"begin":781,"end":801},"obj":"Disease"}],"attributes":[{"id":"A913","pred":"tao:has_database_id","subj":"913","obj":"Tax:9606"},{"id":"A914","pred":"tao:has_database_id","subj":"914","obj":"Tax:2697049"},{"id":"A915","pred":"tao:has_database_id","subj":"915","obj":"Tax:11118"},{"id":"A916","pred":"tao:has_database_id","subj":"916","obj":"MESH:D009584"},{"id":"A917","pred":"tao:has_database_id","subj":"917","obj":"MESH:D012794"},{"id":"A918","pred":"tao:has_database_id","subj":"918","obj":"MESH:D005732"},{"id":"A919","pred":"tao:has_database_id","subj":"919","obj":"MESH:D000073893"},{"id":"A920","pred":"tao:has_database_id","subj":"920","obj":"MESH:D006017"},{"id":"A923","pred":"tao:has_database_id","subj":"923","obj":"MESH:D012794"},{"id":"A925","pred":"tao:has_database_id","subj":"925","obj":"MESH:D019158"},{"id":"A926","pred":"tao:has_database_id","subj":"926","obj":"MESH:D005732"},{"id":"A927","pred":"tao:has_database_id","subj":"927","obj":"MESH:D019158"},{"id":"A928","pred":"tao:has_database_id","subj":"928","obj":"MESH:D007239"},{"id":"A929","pred":"tao:has_database_id","subj":"929","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T651","span":{"begin":4,"end":9},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T652","span":{"begin":122,"end":132},"obj":"SP_7"},{"id":"T653","span":{"begin":225,"end":233},"obj":"CHEBI:36916;CHEBI:36916"},{"id":"T654","span":{"begin":243,"end":248},"obj":"CHEBI:33250;CHEBI:33250"},{"id":"T655","span":{"begin":344,"end":356},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T656","span":{"begin":361,"end":373},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T657","span":{"begin":549,"end":554},"obj":"NCBITaxon:10239"},{"id":"T658","span":{"begin":561,"end":569},"obj":"NCBITaxon:2"},{"id":"T659","span":{"begin":576,"end":584},"obj":"GO:0016020"},{"id":"T660","span":{"begin":594,"end":601},"obj":"CHEBI:60425;CHEBI:60425"},{"id":"T661","span":{"begin":621,"end":633},"obj":"GO:0009986"},{"id":"T662","span":{"begin":634,"end":645},"obj":"CHEBI:33563;CHEBI:33563"},{"id":"T663","span":{"begin":781,"end":791},"obj":"SP_7"},{"id":"T664","span":{"begin":859,"end":871},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T665","span":{"begin":944,"end":957},"obj":"NCBITaxon:11118"},{"id":"T666","span":{"begin":1016,"end":1027},"obj":"CHEBI:26667;CHEBI:26667"},{"id":"T667","span":{"begin":1039,"end":1051},"obj":"CHEBI:5386;CHEBI:5386"},{"id":"T668","span":{"begin":1078,"end":1083},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T669","span":{"begin":1131,"end":1144},"obj":"CHEBI:17089;CHEBI:17089;BV_11"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T200","span":{"begin":361,"end":373},"obj":"Body_part"},{"id":"T201","span":{"begin":377,"end":385},"obj":"Body_part"},{"id":"T202","span":{"begin":488,"end":495},"obj":"Body_part"},{"id":"T203","span":{"begin":496,"end":501},"obj":"Body_part"},{"id":"T204","span":{"begin":602,"end":610},"obj":"Body_part"},{"id":"T205","span":{"begin":621,"end":633},"obj":"Body_part"},{"id":"T206","span":{"begin":621,"end":625},"obj":"Body_part"},{"id":"T207","span":{"begin":634,"end":645},"obj":"Body_part"},{"id":"T208","span":{"begin":1039,"end":1051},"obj":"Body_part"},{"id":"T209","span":{"begin":1131,"end":1144},"obj":"Body_part"}],"attributes":[{"id":"A200","pred":"fma_id","subj":"T200","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A201","pred":"fma_id","subj":"T201","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A202","pred":"fma_id","subj":"T202","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A203","pred":"fma_id","subj":"T203","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A204","pred":"fma_id","subj":"T204","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A205","pred":"fma_id","subj":"T205","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A206","pred":"fma_id","subj":"T206","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A207","pred":"fma_id","subj":"T207","obj":"http://purl.org/sig/ont/fma/fma82780"},{"id":"A208","pred":"fma_id","subj":"T208","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A209","pred":"fma_id","subj":"T209","obj":"http://purl.org/sig/ont/fma/fma62925"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T141","span":{"begin":122,"end":130},"obj":"Disease"},{"id":"T142","span":{"begin":594,"end":601},"obj":"Disease"},{"id":"T143","span":{"begin":781,"end":789},"obj":"Disease"},{"id":"T144","span":{"begin":792,"end":801},"obj":"Disease"}],"attributes":[{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0019065"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T239","span":{"begin":208,"end":209},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T240","span":{"begin":549,"end":554},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T241","span":{"begin":556,"end":558},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T242","span":{"begin":561,"end":569},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T243","span":{"begin":576,"end":584},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T244","span":{"begin":621,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T678","span":{"begin":4,"end":9},"obj":"Chemical"},{"id":"T679","span":{"begin":32,"end":41},"obj":"Chemical"},{"id":"T680","span":{"begin":234,"end":242},"obj":"Chemical"},{"id":"T681","span":{"begin":243,"end":248},"obj":"Chemical"},{"id":"T682","span":{"begin":344,"end":356},"obj":"Chemical"},{"id":"T683","span":{"begin":351,"end":356},"obj":"Chemical"},{"id":"T684","span":{"begin":361,"end":373},"obj":"Chemical"},{"id":"T685","span":{"begin":377,"end":385},"obj":"Chemical"},{"id":"T686","span":{"begin":488,"end":495},"obj":"Chemical"},{"id":"T687","span":{"begin":602,"end":610},"obj":"Chemical"},{"id":"T688","span":{"begin":634,"end":645},"obj":"Chemical"},{"id":"T689","span":{"begin":734,"end":743},"obj":"Chemical"},{"id":"T690","span":{"begin":859,"end":871},"obj":"Chemical"},{"id":"T691","span":{"begin":866,"end":871},"obj":"Chemical"},{"id":"T692","span":{"begin":1023,"end":1027},"obj":"Chemical"},{"id":"T693","span":{"begin":1039,"end":1051},"obj":"Chemical"},{"id":"T694","span":{"begin":1078,"end":1083},"obj":"Chemical"},{"id":"T695","span":{"begin":1107,"end":1118},"obj":"Chemical"},{"id":"T696","span":{"begin":1114,"end":1118},"obj":"Chemical"},{"id":"T697","span":{"begin":1131,"end":1144},"obj":"Chemical"}],"attributes":[{"id":"A678","pred":"chebi_id","subj":"T678","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A679","pred":"chebi_id","subj":"T679","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A680","pred":"chebi_id","subj":"T680","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A681","pred":"chebi_id","subj":"T681","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A682","pred":"chebi_id","subj":"T682","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A683","pred":"chebi_id","subj":"T683","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A684","pred":"chebi_id","subj":"T684","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A685","pred":"chebi_id","subj":"T685","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A686","pred":"chebi_id","subj":"T686","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A687","pred":"chebi_id","subj":"T687","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A688","pred":"chebi_id","subj":"T688","obj":"http://purl.obolibrary.org/obo/CHEBI_33563"},{"id":"A689","pred":"chebi_id","subj":"T689","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A690","pred":"chebi_id","subj":"T690","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A691","pred":"chebi_id","subj":"T691","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A692","pred":"chebi_id","subj":"T692","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A693","pred":"chebi_id","subj":"T693","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A694","pred":"chebi_id","subj":"T694","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A695","pred":"chebi_id","subj":"T695","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A696","pred":"chebi_id","subj":"T696","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A697","pred":"chebi_id","subj":"T697","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"LitCovid-sentences","denotations":[{"id":"T225","span":{"begin":0,"end":140},"obj":"Sentence"},{"id":"T226","span":{"begin":141,"end":268},"obj":"Sentence"},{"id":"T227","span":{"begin":269,"end":394},"obj":"Sentence"},{"id":"T228","span":{"begin":395,"end":646},"obj":"Sentence"},{"id":"T229","span":{"begin":647,"end":802},"obj":"Sentence"},{"id":"T230","span":{"begin":803,"end":963},"obj":"Sentence"},{"id":"T231","span":{"begin":964,"end":1052},"obj":"Sentence"},{"id":"T232","span":{"begin":1053,"end":1145},"obj":"Sentence"},{"id":"T233","span":{"begin":1146,"end":1191},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}

{"project":"2_test","denotations":[{"id":"32251731-20807455-48149959","span":{"begin":390,"end":392},"obj":"20807455"},{"id":"32251731-11792705-48149960","span":{"begin":556,"end":558},"obj":"11792705"},{"id":"32251731-16953581-48149961","span":{"begin":571,"end":573},"obj":"16953581"},{"id":"32251731-31431523-48149962","span":{"begin":586,"end":588},"obj":"31431523"},{"id":"32251731-31160783-48149963","span":{"begin":959,"end":961},"obj":"31160783"},{"id":"T49930","span":{"begin":390,"end":392},"obj":"20807455"},{"id":"T40722","span":{"begin":556,"end":558},"obj":"11792705"},{"id":"T7321","span":{"begin":571,"end":573},"obj":"16953581"},{"id":"T54855","span":{"begin":586,"end":588},"obj":"31431523"},{"id":"T16824","span":{"begin":959,"end":961},"obj":"31160783"}],"text":"Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. Further studies will help clarify this point."}