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PMC:7128678 / 28796-29987 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
913 99-107 Species denotes patients Tax:9606
914 122-132 Species denotes SARS-CoV-2 Tax:2697049
915 944-957 Species denotes coronaviruses Tax:11118
916 234-242 Chemical denotes nitrogen MESH:D009584
917 344-356 Chemical denotes sialic acids MESH:D012794
918 361-373 Chemical denotes gangliosides MESH:D005732
919 496-501 Chemical denotes sugar MESH:D000073893
920 634-645 Chemical denotes glycolipids MESH:D006017
921 766-772 Chemical denotes CLQ-OH
922 836-842 Chemical denotes CLQ-OH
923 859-871 Chemical denotes sialic acids MESH:D012794
924 996-1002 Chemical denotes CLQ-OH
925 1016-1027 Chemical denotes sialic-acid MESH:D019158
926 1039-1051 Chemical denotes gangliosides MESH:D005732
927 1107-1118 Chemical denotes sialic acid MESH:D019158
928 108-116 Disease denotes infected MESH:D007239
929 781-801 Disease denotes SARS-CoV-2 infection MESH:C000657245

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T651 4-9 CHEBI:23888;CHEBI:23888 denotes drugs
T652 122-132 SP_7 denotes SARS-CoV-2
T653 225-233 CHEBI:36916;CHEBI:36916 denotes cationic
T654 243-248 CHEBI:33250;CHEBI:33250 denotes atoms
T655 344-356 CHEBI:26667;CHEBI:26667 denotes sialic acids
T656 361-373 CHEBI:5386;CHEBI:5386 denotes gangliosides
T657 549-554 NCBITaxon:10239 denotes virus
T658 561-569 NCBITaxon:2 denotes bacteria
T659 576-584 GO:0016020 denotes membrane
T660 594-601 CHEBI:60425;CHEBI:60425 denotes amyloid
T661 621-633 GO:0009986 denotes cell surface
T662 634-645 CHEBI:33563;CHEBI:33563 denotes glycolipids
T663 781-791 SP_7 denotes SARS-CoV-2
T664 859-871 CHEBI:26667;CHEBI:26667 denotes sialic acids
T665 944-957 NCBITaxon:11118 denotes coronaviruses
T666 1016-1027 CHEBI:26667;CHEBI:26667 denotes sialic-acid
T667 1039-1051 CHEBI:5386;CHEBI:5386 denotes gangliosides
T668 1078-1083 CHEBI:23888;CHEBI:23888 denotes drugs
T669 1131-1144 CHEBI:17089;CHEBI:17089;BV_11 denotes glycoproteins

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T200 361-373 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T201 377-385 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T202 488-495 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T203 496-501 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T204 602-610 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T205 621-633 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T206 621-625 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T207 634-645 Body_part denotes glycolipids http://purl.org/sig/ont/fma/fma82780
T208 1039-1051 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T209 1131-1144 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T141 122-130 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 594-601 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T143 781-789 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 792-801 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T239 208-209 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 549-554 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T241 556-558 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T242 561-569 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T243 576-584 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T244 621-625 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T678 4-9 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T679 32-41 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T680 234-242 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T681 243-248 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T682 344-356 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T683 351-356 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T684 361-373 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T685 377-385 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T686 488-495 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T687 602-610 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T688 634-645 Chemical denotes glycolipids http://purl.obolibrary.org/obo/CHEBI_33563
T689 734-743 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T690 859-871 Chemical denotes sialic acids http://purl.obolibrary.org/obo/CHEBI_26667
T691 866-871 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T692 1023-1027 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T693 1039-1051 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T694 1078-1083 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T695 1107-1118 Chemical denotes sialic acid http://purl.obolibrary.org/obo/CHEBI_26667
T696 1114-1118 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T697 1131-1144 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T225 0-140 Sentence denotes Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12].
T226 141-268 Sentence denotes Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings.
T227 269-394 Sentence denotes Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26].
T228 395-646 Sentence denotes Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids.
T229 647-802 Sentence denotes This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection.
T230 803-963 Sentence denotes First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23].
T231 964-1052 Sentence denotes Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides.
T232 1053-1145 Sentence denotes Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins.
T233 1146-1191 Sentence denotes Further studies will help clarify this point.

2_test

Id Subject Object Predicate Lexical cue
32251731-20807455-48149959 390-392 20807455 denotes 26
32251731-11792705-48149960 556-558 11792705 denotes 27
32251731-16953581-48149961 571-573 16953581 denotes 28
32251731-31431523-48149962 586-588 31431523 denotes 13
32251731-31160783-48149963 959-961 31160783 denotes 23
T49930 390-392 20807455 denotes 26
T40722 556-558 11792705 denotes 27
T7321 571-573 16953581 denotes 28
T54855 586-588 31431523 denotes 13
T16824 959-961 31160783 denotes 23