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PMC:7128678 / 21337-22204 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
618 37-68 Gene denotes angiotensin-converting enzyme-2 Gene:59272
619 70-75 Gene denotes ACE-2 Gene:59272
620 557-558 Gene denotes S Gene:43740568
621 80-90 Species denotes SARS-CoV-2 Tax:2697049
622 20-32 Chemical denotes gangliosides MESH:D005732
623 329-340 Chemical denotes ganglioside MESH:D005732
624 377-382 Chemical denotes Lipid MESH:D008055
625 429-441 Chemical denotes gangliosides MESH:D005732
626 458-469 Chemical denotes cholesterol MESH:D002784
627 730-741 Chemical denotes ganglioside MESH:D005732
628 788-793 Chemical denotes lipid MESH:D008055
629 832-843 Chemical denotes chloroquine MESH:D002738
630 848-866 Chemical denotes hydroxychloroquine MESH:D006886
631 592-601 Disease denotes infection MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T453 20-32 CHEBI:5386;CHEBI:5386 denotes gangliosides
T454 37-68 PG_10;PR:000003622 denotes angiotensin-converting enzyme-2
T455 70-75 G_3;PG_10;PR:000003622 denotes ACE-2
T456 80-84 PR:000014459;SP_7 denotes SARS
T457 84-90 SP_7 denotes -CoV-2
T458 114-119 NCBITaxon:10239 denotes viral
T459 150-157 SO:0000417 denotes domains
T460 248-254 SO:0000417 denotes domain
T461 268-273 G_3;PG_10;PR:000003622 denotes ACE-2
T462 303-309 SO:0000417 denotes domain
T463 329-340 CHEBI:16856;CHEBI:16856 denotes ganglioside
T464 346-352 SO:0000417 denotes domain
T465 360-375 GO:0005886 denotes plasma membrane
T466 377-382 CHEBI:18059;CHEBI:18059;GO:0045121 denotes Lipid
T467 383-388 GO:0045121 denotes rafts
T468 400-408 GO:0016020 denotes membrane
T469 409-416 GO:0044425 denotes domains
T470 429-441 CHEBI:5386;CHEBI:5386 denotes gangliosides
T471 458-469 CHEBI:16113;CHEBI:16113 denotes cholesterol
T472 551-556 NCBITaxon:10239 denotes viral
T473 557-566 PG_1 denotes S protein
T474 730-741 CHEBI:5386;CHEBI:5386 denotes ganglioside
T475 750-756 SO:0000417 denotes domain
T476 788-793 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T477 794-799 GO:0045121 denotes rafts
T478 832-843 CHEBI:3638;CHEBI:3638;DG_10 denotes chloroquine
T479 848-866 CHEBI:5801;CHEBI:5801;DG_20 denotes hydroxychloroquine

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T131 20-32 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T132 101-108 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T133 120-127 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 329-340 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T135 360-375 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T136 377-382 Body_part denotes Lipid http://purl.org/sig/ont/fma/fma67264
T137 429-441 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T138 559-566 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 673-683 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T140 730-741 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T141 788-793 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T92 80-88 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 311-314 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T95 592-601 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 708-711 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T167 360-366 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T168 367-375 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 400-408 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T170 489-490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 673-692 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T172 673-692 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T173 697-700 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T174 717-718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T498 20-32 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T499 37-48 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T500 101-108 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T501 120-127 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T502 329-340 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T503 377-382 Chemical denotes Lipid http://purl.obolibrary.org/obo/CHEBI_18059
T504 429-441 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T505 458-469 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T506 559-566 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T507 673-683 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T508 673-678 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T509 679-683 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T510 730-741 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T511 788-793 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T512 832-843 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T513 848-866 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T180 110-226 Sentence denotes The viral protein displays two distinct domains, the tips of which are available for distinct types of interactions.
T181 227-376 Sentence denotes The receptor-binding domain binds to the ACE-2 receptor, and the N-terminal domain (NTD) binds to the ganglioside-rich domain of the plasma membrane.
T182 377-610 Sentence denotes Lipid rafts, which are membrane domains enriched in gangliosides (in yellow) and cholesterol (in blue), provide a perfect attractive interface for adequately positioning the viral S protein at the first step of the infection process.
T183 611-867 Sentence denotes These structural and molecular modelling studies suggest that amino acid residues 111–162 of the NTD form a functional ganglioside-binding domain, the interaction of which with lipid rafts can be efficiently prevented by chloroquine and hydroxychloroquine.