PMC:7127386 / 957-1294 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"45","span":{"begin":201,"end":211},"obj":"Species"},{"id":"46","span":{"begin":181,"end":191},"obj":"Chemical"},{"id":"47","span":{"begin":227,"end":234},"obj":"CellLine"},{"id":"51","span":{"begin":304,"end":314},"obj":"Species"},{"id":"52","span":{"begin":267,"end":276},"obj":"Chemical"},{"id":"53","span":{"begin":285,"end":294},"obj":"Chemical"}],"attributes":[{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"Tax:2697049"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:C000606551"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"CVCL:0574"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Tax:2697049"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"MESH:D061466"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"MESH:D019438"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":106,"end":112},"obj":"Body_part"},{"id":"T3","span":{"begin":235,"end":240},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T5","span":{"begin":201,"end":209},"obj":"Disease"},{"id":"T6","span":{"begin":304,"end":312},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T4","span":{"begin":106,"end":112},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T5","span":{"begin":227,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T13","span":{"begin":267,"end":276},"obj":"Chemical"},{"id":"T14","span":{"begin":285,"end":294},"obj":"Chemical"}],"attributes":[{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}

{"project":"LitCovid-sentences","denotations":[{"id":"T8","span":{"begin":2,"end":165},"obj":"Sentence"},{"id":"T9","span":{"begin":167,"end":177},"obj":"Sentence"},{"id":"T10","span":{"begin":178,"end":263},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T24","span":{"begin":74,"end":83},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T25","span":{"begin":106,"end":112},"obj":"UBERON:0001969"},{"id":"T26","span":{"begin":181,"end":191},"obj":"DG_28"},{"id":"T27","span":{"begin":201,"end":211},"obj":"SP_7"},{"id":"T28","span":{"begin":212,"end":223},"obj":"GO:0006260"},{"id":"T29","span":{"begin":227,"end":231},"obj":"CL_6"},{"id":"T30","span":{"begin":267,"end":276},"obj":"DG_23"},{"id":"T31","span":{"begin":285,"end":294},"obj":"DG_30"},{"id":"T32","span":{"begin":304,"end":314},"obj":"SP_7"},{"id":"T33","span":{"begin":315,"end":326},"obj":"GO:0006260"},{"id":"T65617","span":{"begin":74,"end":83},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T6727","span":{"begin":106,"end":112},"obj":"UBERON:0001969"},{"id":"T54351","span":{"begin":181,"end":191},"obj":"DG_28"},{"id":"T83036","span":{"begin":201,"end":211},"obj":"SP_7"},{"id":"T96493","span":{"begin":212,"end":223},"obj":"GO:0006260"},{"id":"T85588","span":{"begin":227,"end":231},"obj":"CL_6"},{"id":"T81617","span":{"begin":267,"end":276},"obj":"DG_23"},{"id":"T3856","span":{"begin":285,"end":294},"obj":"DG_30"},{"id":"T86607","span":{"begin":304,"end":314},"obj":"SP_7"},{"id":"T41304","span":{"begin":315,"end":326},"obj":"GO:0006260"},{"id":"T83525","span":{"begin":123,"end":133},"obj":"DG_28"},{"id":"T59770","span":{"begin":135,"end":142},"obj":"DG_28"},{"id":"T32737","span":{"begin":147,"end":154},"obj":"CHEBI:50266;CHEBI:50266"},{"id":"T67513","span":{"begin":158,"end":168},"obj":"CHEBI:22260;CHEBI:22260"},{"id":"T44435","span":{"begin":226,"end":237},"obj":"NCBITaxon:4894"},{"id":"T45810","span":{"begin":239,"end":254},"obj":"NCBITaxon:7656"},{"id":"T98605","span":{"begin":260,"end":275},"obj":"NCBITaxon:11118"}],"text":". Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits.\n\nHighlights\n• Remdesivir inhibits SARS-CoV-2 replication in Vero-E6 cells with EC50 at 23.15 μM.\n• Lopinavir but not ritonavir inhibits SARS-CoV-2 replication with EC50 "}