PMC:7118659 / 17014-18430 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7118659","sourcedb":"PMC","sourceid":"7118659","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7118659","text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein 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