PMC:7118659 / 17014-18430 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T8","span":{"begin":474,"end":485},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T9","span":{"begin":500,"end":511},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T10","span":{"begin":654,"end":665},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T11","span":{"begin":680,"end":691},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T12","span":{"begin":764,"end":775},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T13","span":{"begin":918,"end":929},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T102","span":{"begin":334,"end":349},"obj":"Body_part"},{"id":"T103","span":{"begin":334,"end":341},"obj":"Body_part"},{"id":"T104","span":{"begin":392,"end":395},"obj":"Body_part"},{"id":"T105","span":{"begin":442,"end":450},"obj":"Body_part"},{"id":"T106","span":{"begin":641,"end":644},"obj":"Body_part"},{"id":"T107","span":{"begin":781,"end":784},"obj":"Body_part"},{"id":"T108","span":{"begin":792,"end":801},"obj":"Body_part"},{"id":"T109","span":{"begin":1186,"end":1190},"obj":"Body_part"},{"id":"T110","span":{"begin":1240,"end":1247},"obj":"Body_part"},{"id":"T111","span":{"begin":1288,"end":1295},"obj":"Body_part"},{"id":"T112","span":{"begin":1403,"end":1410},"obj":"Body_part"}],"attributes":[{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma67110"},{"id":"A104","pred":"fma_id","subj":"T104","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p76585s9","span":{"begin":897,"end":910},"obj":"MPA"},{"id":"p76585s14","span":{"begin":925,"end":942},"obj":"MPA"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T104","span":{"begin":519,"end":527},"obj":"Disease"},{"id":"T105","span":{"begin":747,"end":755},"obj":"Disease"},{"id":"T106","span":{"begin":1275,"end":1283},"obj":"Disease"}],"attributes":[{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T216","span":{"begin":8,"end":13},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T217","span":{"begin":118,"end":123},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T218","span":{"begin":786,"end":791},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T219","span":{"begin":811,"end":812},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T220","span":{"begin":846,"end":847},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T221","span":{"begin":1038,"end":1040},"obj":"http://purl.obolibrary.org/obo/CLO_0001527"},{"id":"T222","span":{"begin":1186,"end":1190},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T223","span":{"begin":1217,"end":1225},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T224","span":{"begin":1310,"end":1320},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T225","span":{"begin":1383,"end":1393},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T184","span":{"begin":80,"end":91},"obj":"Chemical"},{"id":"T185","span":{"begin":293,"end":304},"obj":"Chemical"},{"id":"T186","span":{"begin":334,"end":349},"obj":"Chemical"},{"id":"T187","span":{"begin":342,"end":349},"obj":"Chemical"},{"id":"T188","span":{"begin":442,"end":450},"obj":"Chemical"},{"id":"T189","span":{"begin":481,"end":485},"obj":"Chemical"},{"id":"T190","span":{"begin":487,"end":511},"obj":"Chemical"},{"id":"T191","span":{"begin":500,"end":511},"obj":"Chemical"},{"id":"T192","span":{"begin":507,"end":511},"obj":"Chemical"},{"id":"T193","span":{"begin":530,"end":541},"obj":"Chemical"},{"id":"T194","span":{"begin":661,"end":665},"obj":"Chemical"},{"id":"T195","span":{"begin":667,"end":691},"obj":"Chemical"},{"id":"T196","span":{"begin":680,"end":691},"obj":"Chemical"},{"id":"T197","span":{"begin":687,"end":691},"obj":"Chemical"},{"id":"T198","span":{"begin":771,"end":775},"obj":"Chemical"},{"id":"T199","span":{"begin":802,"end":809},"obj":"Chemical"},{"id":"T200","span":{"begin":848,"end":859},"obj":"Chemical"},{"id":"T201","span":{"begin":918,"end":929},"obj":"Chemical"},{"id":"T202","span":{"begin":925,"end":929},"obj":"Chemical"},{"id":"T203","span":{"begin":1240,"end":1247},"obj":"Chemical"},{"id":"T204","span":{"begin":1288,"end":1295},"obj":"Chemical"},{"id":"T205","span":{"begin":1403,"end":1410},"obj":"Chemical"}],"attributes":[{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A186","pred":"chebi_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A187","pred":"chebi_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A189","pred":"chebi_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A190","pred":"chebi_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/CHEBI_28879"},{"id":"A191","pred":"chebi_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A193","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A194","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_28879"},{"id":"A196","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A197","pred":"chebi_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A199","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T45","span":{"begin":897,"end":910},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T46","span":{"begin":930,"end":942},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":334,"end":349},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"532","span":{"begin":250,"end":266},"obj":"Gene"},{"id":"533","span":{"begin":268,"end":271},"obj":"Gene"},{"id":"534","span":{"begin":293,"end":324},"obj":"Gene"},{"id":"535","span":{"begin":326,"end":330},"obj":"Gene"},{"id":"536","span":{"begin":530,"end":561},"obj":"Gene"},{"id":"537","span":{"begin":563,"end":567},"obj":"Gene"},{"id":"538","span":{"begin":569,"end":576},"obj":"Gene"},{"id":"539","span":{"begin":577,"end":582},"obj":"Gene"},{"id":"540","span":{"begin":584,"end":592},"obj":"Gene"},{"id":"541","span":{"begin":594,"end":601},"obj":"Gene"},{"id":"542","span":{"begin":707,"end":729},"obj":"Gene"},{"id":"543","span":{"begin":731,"end":735},"obj":"Gene"},{"id":"544","span":{"begin":142,"end":153},"obj":"Species"},{"id":"545","span":{"begin":240,"end":249},"obj":"Species"},{"id":"546","span":{"begin":283,"end":292},"obj":"Species"},{"id":"547","span":{"begin":365,"end":380},"obj":"Species"},{"id":"548","span":{"begin":382,"end":391},"obj":"Species"},{"id":"549","span":{"begin":519,"end":527},"obj":"Species"},{"id":"550","span":{"begin":631,"end":640},"obj":"Species"},{"id":"551","span":{"begin":696,"end":704},"obj":"Species"},{"id":"552","span":{"begin":747,"end":757},"obj":"Species"},{"id":"553","span":{"begin":764,"end":775},"obj":"Chemical"},{"id":"557","span":{"begin":8,"end":25},"obj":"Species"},{"id":"558","span":{"begin":27,"end":31},"obj":"Species"},{"id":"559","span":{"begin":80,"end":91},"obj":"Chemical"},{"id":"561","span":{"begin":786,"end":791},"obj":"Species"},{"id":"565","span":{"begin":891,"end":895},"obj":"Gene"},{"id":"566","span":{"begin":848,"end":859},"obj":"Chemical"},{"id":"567","span":{"begin":918,"end":929},"obj":"Chemical"},{"id":"574","span":{"begin":1230,"end":1235},"obj":"Gene"},{"id":"575","span":{"begin":1324,"end":1335},"obj":"Gene"},{"id":"576","span":{"begin":1368,"end":1373},"obj":"Gene"},{"id":"577","span":{"begin":1252,"end":1265},"obj":"Species"},{"id":"578","span":{"begin":1275,"end":1283},"obj":"Species"},{"id":"579","span":{"begin":1345,"end":1353},"obj":"Species"}],"attributes":[{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"Gene:290"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"Gene:290"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"Gene:59272"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"Gene:59272"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"Gene:59272"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"Gene:59272"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"Gene:30835"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"Gene:30835"},{"id":"A540","pred":"tao:has_database_id","subj":"540","obj":"Gene:10332"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"Gene:30835"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"Gene:1803"},{"id":"A543","pred":"tao:has_database_id","subj":"543","obj":"Gene:1803"},{"id":"A544","pred":"tao:has_database_id","subj":"544","obj":"Tax:11118"},{"id":"A545","pred":"tao:has_database_id","subj":"545","obj":"Tax:11137"},{"id":"A546","pred":"tao:has_database_id","subj":"546","obj":"Tax:277944"},{"id":"A547","pred":"tao:has_database_id","subj":"547","obj":"Tax:694002"},{"id":"A548","pred":"tao:has_database_id","subj":"548","obj":"Tax:31631"},{"id":"A549","pred":"tao:has_database_id","subj":"549","obj":"Tax:694009"},{"id":"A550","pred":"tao:has_database_id","subj":"550","obj":"Tax:290028"},{"id":"A551","pred":"tao:has_database_id","subj":"551","obj":"Tax:1335626"},{"id":"A552","pred":"tao:has_database_id","subj":"552","obj":"Tax:2697049"},{"id":"A553","pred":"tao:has_database_id","subj":"553","obj":"MESH:D019158"},{"id":"A557","pred":"tao:has_database_id","subj":"557","obj":"Tax:694448"},{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"Tax:694448"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"MESH:D002738"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"Tax:9606"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"Gene:59272"},{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"MESH:D002738"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"MESH:D019158"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"Gene:43740568"},{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"Gene:1514"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"Gene:5045"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"Tax:11118"},{"id":"A578","pred":"tao:has_database_id","subj":"578","obj":"Tax:694009"},{"id":"A579","pred":"tao:has_database_id","subj":"579","obj":"Tax:1335626"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus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1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T97","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T98","span":{"begin":142,"end":221},"obj":"Sentence"},{"id":"T99","span":{"begin":222,"end":238},"obj":"Sentence"},{"id":"T100","span":{"begin":239,"end":281},"obj":"Sentence"},{"id":"T101","span":{"begin":282,"end":333},"obj":"Sentence"},{"id":"T102","span":{"begin":334,"end":364},"obj":"Sentence"},{"id":"T103","span":{"begin":365,"end":380},"obj":"Sentence"},{"id":"T104","span":{"begin":381,"end":517},"obj":"Sentence"},{"id":"T105","span":{"begin":518,"end":629},"obj":"Sentence"},{"id":"T106","span":{"begin":630,"end":694},"obj":"Sentence"},{"id":"T107","span":{"begin":695,"end":745},"obj":"Sentence"},{"id":"T108","span":{"begin":746,"end":776},"obj":"Sentence"},{"id":"T109","span":{"begin":777,"end":780},"obj":"Sentence"},{"id":"T110","span":{"begin":781,"end":810},"obj":"Sentence"},{"id":"T111","span":{"begin":811,"end":845},"obj":"Sentence"},{"id":"T112","span":{"begin":846,"end":943},"obj":"Sentence"},{"id":"T113","span":{"begin":944,"end":980},"obj":"Sentence"},{"id":"T114","span":{"begin":981,"end":1009},"obj":"Sentence"},{"id":"T115","span":{"begin":1010,"end":1042},"obj":"Sentence"},{"id":"T116","span":{"begin":1043,"end":1077},"obj":"Sentence"},{"id":"T117","span":{"begin":1078,"end":1111},"obj":"Sentence"},{"id":"T118","span":{"begin":1112,"end":1144},"obj":"Sentence"},{"id":"T119","span":{"begin":1145,"end":1416},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}

{"project":"2_test","denotations":[{"id":"32171740-24217413-48148591","span":{"begin":841,"end":843},"obj":"24217413"},{"id":"32171740-25187545-48148592","span":{"begin":976,"end":978},"obj":"25187545"},{"id":"32171740-8505072-48148593","span":{"begin":1005,"end":1007},"obj":"8505072"},{"id":"32171740-24753610-48148594","span":{"begin":1038,"end":1040},"obj":"24753610"},{"id":"32171740-3380803-48148595","span":{"begin":1073,"end":1075},"obj":"3380803"},{"id":"32171740-25926653-48148596","span":{"begin":1107,"end":1109},"obj":"25926653"},{"id":"32171740-18987136-48148597","span":{"begin":1140,"end":1142},"obj":"18987136"},{"id":"32171740-21435673-48148598","span":{"begin":1337,"end":1339},"obj":"21435673"},{"id":"32171740-25288733-48148599","span":{"begin":1412,"end":1414},"obj":"25288733"},{"id":"T82592","span":{"begin":841,"end":843},"obj":"24217413"},{"id":"T9803","span":{"begin":976,"end":978},"obj":"25187545"},{"id":"T63293","span":{"begin":1005,"end":1007},"obj":"8505072"},{"id":"T56770","span":{"begin":1038,"end":1040},"obj":"24753610"},{"id":"T98705","span":{"begin":1073,"end":1075},"obj":"3380803"},{"id":"T76945","span":{"begin":1107,"end":1109},"obj":"25926653"},{"id":"T10080","span":{"begin":1140,"end":1142},"obj":"18987136"},{"id":"T19530","span":{"begin":1337,"end":1339},"obj":"21435673"},{"id":"T61032","span":{"begin":1412,"end":1414},"obj":"25288733"}],"text":"Table 1 Human coronavirus (HCoV) receptors/co-receptors as possible targets for chloroquine-induced inhibition of the virus replication cycle\nCoronavirus Receptora May also bind Replication cycle inhibited by chloroquineb\nAlphacoronavirus\n HCoV-229E Aminopeptidase N (APN)/CD13 Yes\n HCoV-NL63 Angiotensin-converting enzyme 2 (ACE2) ?\nHeparan sulfate proteoglycansc\nBetacoronavirus\n HCoV-OC43 HLA class Id, IFN-inducible transmembrane (IFITM) proteins in endocytic vesiclese Sialic acid (O-acetylated sialic acid)f Yes\n SARS-CoV-1 Angiotensin-converting enzyme 2 (ACE2) DC-SIGN/CD209, DC-SIGNr, DC-SIGN-related lectin LSECting Yes\n HCoV-HKU1 HLA class Ih Sialic acid (O-acetylated sialic acid) ?\n MERS-CoV i Dipeptidyl peptidase 4 (DPP4)/CD26 Yes\n SARS-CoV-2 ACE2i Sialic acid? Yes\nHLA, human leukocyte antigen.\na Adapted from Graham et al. [91].\nb Chloroquine could interfere with receptor (ACE2) glycosylation and/or sialic acid biosynthesis.\nc According to Milewska et al. [92].\nd According to Collins [93].\ne According to Zhao et al. [94].\nf According to Vlasak et al. [95].\ng According to Huang et al. [96].\nh According to Chan et al. [97].\ni It is worth noting that different host cell proteases are required to activate the spike (S) protein for coronaviruses, such as SARS-CoV-1 S protein that requires activation by cathepsin L [89], or MERS-CoV that requires furin-mediated activation of the S protein [98]."}