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PMC:7116472 / 19710-21531 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
279 65-73 Species denotes patients Tax:9606
280 174-182 Species denotes patients Tax:9606
281 277-285 Species denotes patients Tax:9606
282 306-314 Species denotes patients Tax:9606
283 246-255 Disease denotes mortality MESH:D003643
287 480-489 Disease denotes Mortality MESH:D003643
288 692-701 Disease denotes mortality MESH:D003643
289 838-847 Disease denotes Mortality MESH:D003643
293 1002-1011 Disease denotes mortality MESH:D003643
294 1061-1070 Disease denotes mortality MESH:D003643
295 1354-1363 Disease denotes mortality MESH:D003643
302 1378-1386 Species denotes Patients Tax:9606
303 1509-1517 Species denotes Patients Tax:9606
304 1642-1650 Species denotes patients Tax:9606
305 1451-1460 Disease denotes mortality MESH:D003643
306 1577-1586 Disease denotes mortality MESH:D003643
307 1694-1703 Disease denotes mortality MESH:D003643

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T132 0-16 Sentence denotes Model validation
T133 17-233 Sentence denotes The validation cohort included data from 22 361 patients collected between 21 May 2020 and 29 June 2020 who had at least four weeks of follow-up; 743 (3.3%) patients had no outcome recorded and were considered alive.
T134 234-287 Sentence denotes The overall mortality rate was 30.1% (6729 patients).
T135 288-454 Sentence denotes The median age of patients in the cohort was 76 (interquartile range 60-85) years; 10 178 (45.6%) were female and 17 263 (77%) had at least one comorbidity (table 1).
T136 455-572 Sentence denotes Discrimination of the 4C Mortality Score in the validation cohort was similar to that of the XGBoost model (table 3).
T137 573-830 Sentence denotes Calibration was also found to be excellent in the validation cohort: overall observed (30.1%) versus predicted (30.1%) mortality was equal (calibration-in-the-large=0) and calibration was excellent over the range of risk (slope=1, Brier score 0.171; fig 2).
T138 831-952 Sentence denotes The 4C Mortality Score showed good performance in clinically relevant metrics across a range of cut-off values (table 4).
T139 953-1189 Sentence denotes Four risk groups were defined with corresponding mortality rates determined (table 5): low risk (0-3 score, mortality rate 1.2%), intermediate risk (4-8 score, 9.9%), high risk (9-14 score, 31.4%), and very high risk (≥15 score, 61.5%).
T140 1190-1377 Sentence denotes Performance metrics showed a high sensitivity (99.7%) and negative predictive value (98.8%) for the low risk group, covering 7.4% of the cohort and a corresponding mortality rate of 1.2%.
T141 1378-1508 Sentence denotes Patients in the intermediate risk group (score 4-8, n=4889, 21.9%) had a mortality rate of 9.9% (negative predictive value 90.1%).
T142 1509-1752 Sentence denotes Patients in the high risk group (score 9-14, n=11 664, 52.2%) had a mortality rate of 31.4% (negative predictive value 68.6%), while patients scoring 15 or higher (n=4158, 18.6%) had a mortality rate of 61.5% (positive predictive value 61.5%).
T143 1753-1821 Sentence denotes An interactive infographic is available at https://isaric4c.net/risk