PMC:7105881 / 33193-35293 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7105881","sourcedb":"PMC","sourceid":"7105881","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7105881","text":"SARS-CoV RBD contains multiple conformation-dependent epitopes capable of eliciting high-titer neutralizing antibodies; thus, it is a major target for the development of SARS vaccines (He et al., 2004, 2005a; Jiang et al., 2012; Zhu et al., 2013). Subunit vaccines based on the SARS-CoV RBD have been extensively explored. Studies have found that a fusion protein containing RBD and the fragment crystallizable (Fc) region of human IgG1 (RBD-Fc) elicited highly potent neutralizing antibodies against SARS-CoV in the immunized rabbits and mice, which strongly blocked the binding between S1 protein and SARS-CoV receptor ACE2 (He et al., 2004). This RBD protein induced long-term, high-level SARS-CoV S-specific antibodies and neutralizing antibodies that could be maintained for 12 months after immunization, protecting most of the vaccinated mice against SARS-CoV infection (Du et al., 2007). In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010). Significantly, a 293T cell-expressed RBD protein maintains excellent conformation and good antigenicity to bind SARS-CoV RBD-specific neutralizing mAbs. It elicited highly potent neutralizing antibodies that completely protected immunized mice against SARS-CoV challenge (Du et al., 2009b). Particularly, RBDs from the S proteins of Tor2, GD03, and SZ3, representative strains of SARS-CoV isolated from human 2002–2003, 2003–2004, and palm civet strains, can induce high-titer cross-neutralizing antibodies against pseudotyped SARS-CoV expressing respective S proteins (He et al., 2006c). Different from the full-length S protein-based SARS subunit vaccines, no obvious pathogenic effects have been identified in the RBD-based SARS subunit vaccines (Kam et al., 2007; Jaume et al., 2012).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1083","span":{"begin":432,"end":436},"obj":"Gene"},{"id":"1084","span":{"begin":621,"end":625},"obj":"Gene"},{"id":"1085","span":{"begin":0,"end":8},"obj":"Species"},{"id":"1086","span":{"begin":278,"end":286},"obj":"Species"},{"id":"1087","span":{"begin":501,"end":509},"obj":"Species"},{"id":"1088","span":{"begin":527,"end":534},"obj":"Species"},{"id":"1089","span":{"begin":539,"end":543},"obj":"Species"},{"id":"1090","span":{"begin":603,"end":611},"obj":"Species"},{"id":"1091","span":{"begin":692,"end":700},"obj":"Species"},{"id":"1092","span":{"begin":844,"end":848},"obj":"Species"},{"id":"1093","span":{"begin":990,"end":1005},"obj":"Species"},{"id":"1094","span":{"begin":1179,"end":1187},"obj":"Species"},{"id":"1095","span":{"begin":1199,"end":1203},"obj":"Species"},{"id":"1096","span":{"begin":1424,"end":1432},"obj":"Species"},{"id":"1097","span":{"begin":1551,"end":1555},"obj":"Species"},{"id":"1098","span":{"begin":1564,"end":1572},"obj":"Species"},{"id":"1099","span":{"begin":1692,"end":1700},"obj":"Species"},{"id":"1100","span":{"begin":1715,"end":1720},"obj":"Species"},{"id":"1101","span":{"begin":1839,"end":1847},"obj":"Species"},{"id":"1102","span":{"begin":908,"end":919},"obj":"Species"},{"id":"1103","span":{"begin":426,"end":431},"obj":"Species"},{"id":"1104","span":{"begin":1110,"end":1118},"obj":"Species"},{"id":"1105","span":{"begin":857,"end":875},"obj":"Disease"},{"id":"1106","span":{"begin":1013,"end":1016},"obj":"CellLine"},{"id":"1107","span":{"begin":1329,"end":1333},"obj":"CellLine"}],"attributes":[{"id":"A1083","pred":"tao:has_database_id","subj":"1083","obj":"Gene:16017"},{"id":"A1084","pred":"tao:has_database_id","subj":"1084","obj":"Gene:59272"},{"id":"A1085","pred":"tao:has_database_id","subj":"1085","obj":"Tax:694009"},{"id":"A1086","pred":"tao:has_database_id","subj":"1086","obj":"Tax:694009"},{"id":"A1087","pred":"tao:has_database_id","subj":"1087","obj":"Tax:694009"},{"id":"A1088","pred":"tao:has_database_id","subj":"1088","obj":"Tax:9986"},{"id":"A1089","pred":"tao:has_database_id","subj":"1089","obj":"Tax:10090"},{"id":"A1090","pred":"tao:has_database_id","subj":"1090","obj":"Tax:694009"},{"id":"A1091","pred":"tao:has_database_id","subj":"1091","obj":"Tax:694009"},{"id":"A1092","pred":"tao:has_database_id","subj":"1092","obj":"Tax:10090"},{"id":"A1093","pred":"tao:has_database_id","subj":"1093","obj":"Tax:10029"},{"id":"A1094","pred":"tao:has_database_id","subj":"1094","obj":"Tax:694009"},{"id":"A1095","pred":"tao:has_database_id","subj":"1095","obj":"Tax:10090"},{"id":"A1096","pred":"tao:has_database_id","subj":"1096","obj":"Tax:694009"},{"id":"A1097","pred":"tao:has_database_id","subj":"1097","obj":"Tax:10090"},{"id":"A1098","pred":"tao:has_database_id","subj":"1098","obj":"Tax:694009"},{"id":"A1099","pred":"tao:has_database_id","subj":"1099","obj":"Tax:694009"},{"id":"A1100","pred":"tao:has_database_id","subj":"1100","obj":"Tax:9606"},{"id":"A1101","pred":"tao:has_database_id","subj":"1101","obj":"Tax:694009"},{"id":"A1102","pred":"tao:has_database_id","subj":"1102","obj":"Tax:575864"},{"id":"A1103","pred":"tao:has_database_id","subj":"1103","obj":"Tax:9606"},{"id":"A1104","pred":"tao:has_database_id","subj":"1104","obj":"Tax:694009"},{"id":"A1105","pred":"tao:has_database_id","subj":"1105","obj":"MESH:C000657245"},{"id":"A1106","pred":"tao:has_database_id","subj":"1106","obj":"CVCL:0213"},{"id":"A1107","pred":"tao:has_database_id","subj":"1107","obj":"CVCL:0063"},{"subj":"1083","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1084","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1085","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1086","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1087","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1088","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1089","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1090","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1091","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1092","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1093","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1094","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1095","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1096","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1097","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1098","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1099","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1100","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1101","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1102","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1103","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1104","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1105","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1106","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1107","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":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