PMC:7105881 / 33193-35293
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1083 | 432-436 | Gene | denotes | IgG1 | Gene:16017 |
| 1084 | 621-625 | Gene | denotes | ACE2 | Gene:59272 |
| 1085 | 0-8 | Species | denotes | SARS-CoV | Tax:694009 |
| 1086 | 278-286 | Species | denotes | SARS-CoV | Tax:694009 |
| 1087 | 501-509 | Species | denotes | SARS-CoV | Tax:694009 |
| 1088 | 527-534 | Species | denotes | rabbits | Tax:9986 |
| 1089 | 539-543 | Species | denotes | mice | Tax:10090 |
| 1090 | 603-611 | Species | denotes | SARS-CoV | Tax:694009 |
| 1091 | 692-700 | Species | denotes | SARS-CoV | Tax:694009 |
| 1092 | 844-848 | Species | denotes | mice | Tax:10090 |
| 1093 | 990-1005 | Species | denotes | Chinese hamster | Tax:10029 |
| 1094 | 1179-1187 | Species | denotes | SARS-CoV | Tax:694009 |
| 1095 | 1199-1203 | Species | denotes | mice | Tax:10090 |
| 1096 | 1424-1432 | Species | denotes | SARS-CoV | Tax:694009 |
| 1097 | 1551-1555 | Species | denotes | mice | Tax:10090 |
| 1098 | 1564-1572 | Species | denotes | SARS-CoV | Tax:694009 |
| 1099 | 1692-1700 | Species | denotes | SARS-CoV | Tax:694009 |
| 1100 | 1715-1720 | Species | denotes | human | Tax:9606 |
| 1101 | 1839-1847 | Species | denotes | SARS-CoV | Tax:694009 |
| 1102 | 908-919 | Species | denotes | recombinant | Tax:575864 |
| 1103 | 426-431 | Species | denotes | human | Tax:9606 |
| 1104 | 1110-1118 | Species | denotes | SARS-CoV | Tax:694009 |
| 1105 | 857-875 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1106 | 1013-1016 | CellLine | denotes | CHO | CVCL:0213 |
| 1107 | 1329-1333 | CellLine | denotes | 293T | CVCL:0063 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T188 | 356-363 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T189 | 591-598 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T190 | 654-661 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T191 | 1006-1011 | Body_part | denotes | ovary | http://purl.org/sig/ont/fma/fma7209 |
| T192 | 1018-1023 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T193 | 1229-1232 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T194 | 1334-1338 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T195 | 1353-1360 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T196 | 1633-1641 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T197 | 1747-1751 | Body_part | denotes | palm | http://purl.org/sig/ont/fma/fma24920 |
| T198 | 1872-1880 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T199 | 1934-1941 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p63076s43 | 560-567 | NegReg | denotes | blocked |
| p63076s45 | 572-579 | Interaction | denotes | binding |
| p63076s50 | 603-625 | MPA | denotes | SARS-CoV receptor ACE2 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T177 | 0-8 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T178 | 170-174 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T179 | 278-286 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T180 | 501-509 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T181 | 603-611 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T182 | 692-700 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T183 | 857-875 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T184 | 866-875 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T185 | 1110-1118 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T186 | 1179-1187 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T187 | 1424-1432 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T188 | 1564-1572 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T189 | 1692-1700 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T190 | 1839-1847 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T191 | 1948-1952 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T192 | 2039-2043 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T440 | 132-133 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T441 | 347-348 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T442 | 412-414 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T443 | 426-431 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T444 | 442-444 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T445 | 588-590 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T446 | 998-1005 | http://purl.obolibrary.org/obo/NCBITaxon_10026 | denotes | hamster |
| T447 | 1006-1011 | http://www.ebi.ac.uk/efo/EFO_0000973 | denotes | ovary |
| T448 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0002421 | denotes | CHO |
| T449 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0052479 | denotes | CHO |
| T450 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0052480 | denotes | CHO |
| T451 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0052483 | denotes | CHO |
| T452 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0052484 | denotes | CHO |
| T453 | 1013-1016 | http://purl.obolibrary.org/obo/CLO_0052485 | denotes | CHO |
| T454 | 1018-1023 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T455 | 1327-1328 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T456 | 1329-1333 | http://purl.obolibrary.org/obo/CLO_0050894 | denotes | 293T |
| T457 | 1329-1333 | http://purl.obolibrary.org/obo/CLO_0051650 | denotes | 293T |
| T458 | 1329-1333 | http://purl.obolibrary.org/obo/CLO_0052052 | denotes | 293T |
| T459 | 1334-1338 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T460 | 1715-1720 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T196 | 356-363 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T197 | 591-598 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T198 | 654-661 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T199 | 1353-1360 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T200 | 1633-1641 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T201 | 1872-1880 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T202 | 1934-1941 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32265848-15474494-36511136 | 196-200 | 15474494 | denotes | 2004 |
| 32265848-23252385-36511138 | 223-227 | 23252385 | denotes | 2012 |
| 32265848-23977435-36511139 | 241-245 | 23977435 | denotes | 2013 |
| 32265848-15474494-36511140 | 638-642 | 15474494 | denotes | 2004 |
| 32265848-17092615-36511141 | 888-892 | 17092615 | denotes | 2007 |
| 32265848-20374001-36511143 | 1305-1309 | 20374001 | denotes | 2010 |
| 32265848-17049691-36511146 | 2074-2078 | 17049691 | denotes | 2007 |
| 32265848-22311359-36511147 | 2094-2098 | 22311359 | denotes | 2012 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T198 | 0-247 | Sentence | denotes | SARS-CoV RBD contains multiple conformation-dependent epitopes capable of eliciting high-titer neutralizing antibodies; thus, it is a major target for the development of SARS vaccines (He et al., 2004, 2005a; Jiang et al., 2012; Zhu et al., 2013). |
| T199 | 248-322 | Sentence | denotes | Subunit vaccines based on the SARS-CoV RBD have been extensively explored. |
| T200 | 323-644 | Sentence | denotes | Studies have found that a fusion protein containing RBD and the fragment crystallizable (Fc) region of human IgG1 (RBD-Fc) elicited highly potent neutralizing antibodies against SARS-CoV in the immunized rabbits and mice, which strongly blocked the binding between S1 protein and SARS-CoV receptor ACE2 (He et al., 2004). |
| T201 | 645-894 | Sentence | denotes | This RBD protein induced long-term, high-level SARS-CoV S-specific antibodies and neutralizing antibodies that could be maintained for 12 months after immunization, protecting most of the vaccinated mice against SARS-CoV infection (Du et al., 2007). |
| T202 | 895-1311 | Sentence | denotes | In addition, recombinant RBDs (residues 318–510 or 318–536) stably or transiently expressed in Chinese hamster ovary (CHO) cells bound strongly to RBD-specific monoclonal antibodies (mAbs), elicited high-titer anti-SARS-CoV neutralizing antibodies, and protected most, or all, of the SARS-CoV-challenged mice, with undetectable viral RNA and undetectable or significantly reduced viral load (Du et al., 2009c, 2010). |
| T203 | 1312-1464 | Sentence | denotes | Significantly, a 293T cell-expressed RBD protein maintains excellent conformation and good antigenicity to bind SARS-CoV RBD-specific neutralizing mAbs. |
| T204 | 1465-1602 | Sentence | denotes | It elicited highly potent neutralizing antibodies that completely protected immunized mice against SARS-CoV challenge (Du et al., 2009b). |
| T205 | 1603-1900 | Sentence | denotes | Particularly, RBDs from the S proteins of Tor2, GD03, and SZ3, representative strains of SARS-CoV isolated from human 2002–2003, 2003–2004, and palm civet strains, can induce high-titer cross-neutralizing antibodies against pseudotyped SARS-CoV expressing respective S proteins (He et al., 2006c). |
| T206 | 1901-2100 | Sentence | denotes | Different from the full-length S protein-based SARS subunit vaccines, no obvious pathogenic effects have been identified in the RBD-based SARS subunit vaccines (Kam et al., 2007; Jaume et al., 2012). |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T556 | 0-8 | SP_10 | denotes | SARS-CoV |
| T557 | 54-62 | BV_9 | denotes | epitopes |
| T558 | 108-118 | GO:0042571 | denotes | antibodies |
| T559 | 170-174 | SP_10 | denotes | SARS |
| T560 | 278-286 | SP_10 | denotes | SARS-CoV |
| T561 | 426-431 | SP_6;NCBITaxon:9606 | denotes | human |
| T562 | 432-436 | GO:0071735 | denotes | IgG1 |
| T563 | 482-492 | GO:0042571 | denotes | antibodies |
| T564 | 501-509 | SP_10 | denotes | SARS-CoV |
| T565 | 527-534 | NCBITaxon:9986 | denotes | rabbits |
| T566 | 539-543 | NCBITaxon:10088 | denotes | mice |
| T567 | 603-611 | SP_10 | denotes | SARS-CoV |
| T568 | 621-625 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T569 | 692-700 | SP_10 | denotes | SARS-CoV |
| T570 | 712-722 | GO:0042571 | denotes | antibodies |
| T571 | 740-750 | GO:0042571 | denotes | antibodies |
| T572 | 844-848 | NCBITaxon:10088 | denotes | mice |
| T573 | 857-865 | SP_10 | denotes | SARS-CoV |
| T574 | 977-986 | GO:0010467 | denotes | expressed |
| T575 | 1006-1011 | UBERON:0000992 | denotes | ovary |
| T576 | 1066-1076 | GO:0042571 | denotes | antibodies |
| T577 | 1110-1118 | SP_10 | denotes | SARS-CoV |
| T578 | 1132-1142 | GO:0042571 | denotes | antibodies |
| T579 | 1179-1187 | SP_10 | denotes | SARS-CoV |
| T580 | 1199-1203 | NCBITaxon:10088 | denotes | mice |
| T581 | 1223-1228 | NCBITaxon:10239 | denotes | viral |
| T582 | 1275-1280 | NCBITaxon:10239 | denotes | viral |
| T583 | 1329-1333 | CL_4 | denotes | 293T |
| T584 | 1339-1348 | GO:0010467 | denotes | expressed |
| T585 | 1424-1432 | SP_10 | denotes | SARS-CoV |
| T586 | 1504-1514 | GO:0042571 | denotes | antibodies |
| T587 | 1551-1555 | NCBITaxon:10088 | denotes | mice |
| T588 | 1564-1572 | SP_10 | denotes | SARS-CoV |
| T589 | 1645-1649 | PR:000001902 | denotes | Tor2 |
| T590 | 1692-1700 | SP_10 | denotes | SARS-CoV |
| T591 | 1715-1720 | SP_6;NCBITaxon:9606 | denotes | human |
| T592 | 1747-1757 | SP_5 | denotes | palm civet |
| T593 | 1789-1807 | BV_7 | denotes | cross-neutralizing |
| T594 | 1808-1818 | BV_7;GO:0042571 | denotes | antibodies |
| T595 | 1839-1847 | SP_10 | denotes | SARS-CoV |
| T596 | 1848-1858 | GO:0010467 | denotes | expressing |
| T597 | 1932-1941 | PG_1 | denotes | S protein |
| T598 | 1948-1952 | SP_10 | denotes | SARS |
| T599 | 2039-2043 | SP_10 | denotes | SARS |
| T54867 | 0-8 | SP_10 | denotes | SARS-CoV |
| T62823 | 54-62 | BV_9 | denotes | epitopes |
| T18461 | 108-118 | GO:0042571 | denotes | antibodies |
| T90326 | 170-174 | SP_10 | denotes | SARS |
| T58860 | 278-286 | SP_10 | denotes | SARS-CoV |
| T51408 | 426-431 | SP_6;NCBITaxon:9606 | denotes | human |
| T32600 | 432-436 | GO:0071735 | denotes | IgG1 |
| T99084 | 482-492 | GO:0042571 | denotes | antibodies |
| T60337 | 501-509 | SP_10 | denotes | SARS-CoV |
| T29995 | 527-534 | NCBITaxon:9986 | denotes | rabbits |
| T6206 | 539-543 | NCBITaxon:10088 | denotes | mice |
| T53931 | 603-611 | SP_10 | denotes | SARS-CoV |
| T59081 | 621-625 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T14290 | 692-700 | SP_10 | denotes | SARS-CoV |
| T82096 | 712-722 | GO:0042571 | denotes | antibodies |
| T18916 | 740-750 | GO:0042571 | denotes | antibodies |
| T40398 | 844-848 | NCBITaxon:10088 | denotes | mice |
| T74279 | 857-865 | SP_10 | denotes | SARS-CoV |
| T76668 | 977-986 | GO:0010467 | denotes | expressed |
| T74849 | 1006-1011 | UBERON:0000992 | denotes | ovary |
| T10182 | 1066-1076 | GO:0042571 | denotes | antibodies |
| T59383 | 1110-1118 | SP_10 | denotes | SARS-CoV |
| T51937 | 1132-1142 | GO:0042571 | denotes | antibodies |
| T92066 | 1179-1187 | SP_10 | denotes | SARS-CoV |
| T63789 | 1199-1203 | NCBITaxon:10088 | denotes | mice |
| T5217 | 1223-1228 | NCBITaxon:10239 | denotes | viral |
| T50236 | 1275-1280 | NCBITaxon:10239 | denotes | viral |
| T41331 | 1329-1333 | CL_4 | denotes | 293T |
| T5770 | 1339-1348 | GO:0010467 | denotes | expressed |
| T32780 | 1424-1432 | SP_10 | denotes | SARS-CoV |
| T5100 | 1504-1514 | GO:0042571 | denotes | antibodies |
| T62133 | 1551-1555 | NCBITaxon:10088 | denotes | mice |
| T81183 | 1564-1572 | SP_10 | denotes | SARS-CoV |
| T30071 | 1645-1649 | PR:000001902 | denotes | Tor2 |
| T61425 | 1692-1700 | SP_10 | denotes | SARS-CoV |
| T15708 | 1715-1720 | SP_6;NCBITaxon:9606 | denotes | human |
| T97182 | 1747-1757 | SP_5 | denotes | palm civet |
| T7300 | 1789-1807 | BV_7 | denotes | cross-neutralizing |
| T19730 | 1808-1818 | BV_7;GO:0042571 | denotes | antibodies |
| T30325 | 1839-1847 | SP_10 | denotes | SARS-CoV |
| T94233 | 1848-1858 | GO:0010467 | denotes | expressing |
| T73954 | 1932-1941 | PG_1 | denotes | S protein |
| T20931 | 1948-1952 | SP_10 | denotes | SARS |
| T28537 | 2039-2043 | SP_10 | denotes | SARS |