PMC:7105881 / 31627-33152 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7105881","sourcedb":"PMC","sourceid":"7105881","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7105881","text":"Subunit vaccines based on SARS-CoV S protein, including full-length or trimeric S protein, are immunogenic with protection against SARS-CoV infection (He et al., 2006a; Kam et al., 2007; Li et al., 2013). Either insect cell-expressed full-length (FL-S) or extracellular domain (EC-S) SARS-CoV S protein developed high-titer S-specific antibodies with neutralizing activity against pseudotyped SARS-CoV expressing S protein of representative SARS-CoV human and palm civet strains (Tor2, GD03, and SZ3) isolated during the 2002 and 2003 or 2003 and 2004 outbreaks (He et al., 2006a). In addition, full-length S-ectodomain proteins fused with or without a foldon trimeric motif (S or S-foldon) could elicit specific antibody responses and neutralizing antibodies, protecting immunized mice against SARS-CoV challenge with undetectable virus titers in the lungs (Li et al., 2013). Moreover, a subunit vaccine (triSpike) based on a full-length S protein trimer induced specific serum and mucosal antibody responses and efficient neutralizing antibodies against SARS-CoV infection (Kam et al., 2007). Nevertheless, this vaccine also resulted in Fcγ receptor II (FcγRII)-dependent and ACE2-independent ADE, particularly in human monocytic or lymphoblastic cell lines infected with pseudotyped SARS-CoV expressing viral S protein, or in Raji B cells (B-cell lymphoma line) infected with live SARS-CoV (Kam et al., 2007; Jaume et al., 2012), raising significant concerns over the use of full-length S protein as a SARS vaccine target.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1037","span":{"begin":1178,"end":1182},"obj":"Gene"},{"id":"1038","span":{"begin":26,"end":34},"obj":"Species"},{"id":"1039","span":{"begin":284,"end":292},"obj":"Species"},{"id":"1040","span":{"begin":393,"end":401},"obj":"Species"},{"id":"1041","span":{"begin":441,"end":449},"obj":"Species"},{"id":"1042","span":{"begin":450,"end":455},"obj":"Species"},{"id":"1043","span":{"begin":782,"end":786},"obj":"Species"},{"id":"1044","span":{"begin":795,"end":803},"obj":"Species"},{"id":"1045","span":{"begin":1216,"end":1221},"obj":"Species"},{"id":"1046","span":{"begin":1286,"end":1294},"obj":"Species"},{"id":"1047","span":{"begin":1384,"end":1392},"obj":"Species"},{"id":"1048","span":{"begin":131,"end":149},"obj":"Disease"},{"id":"1049","span":{"begin":1056,"end":1074},"obj":"Disease"},{"id":"1050","span":{"begin":1235,"end":1248},"obj":"Disease"},{"id":"1051","span":{"begin":1260,"end":1268},"obj":"Disease"},{"id":"1052","span":{"begin":1350,"end":1358},"obj":"Disease"},{"id":"1053","span":{"begin":1365,"end":1373},"obj":"Disease"},{"id":"1054","span":{"begin":278,"end":282},"obj":"CellLine"},{"id":"1055","span":{"begin":1329,"end":1335},"obj":"CellLine"}],"attributes":[{"id":"A1037","pred":"tao:has_database_id","subj":"1037","obj":"Gene:59272"},{"id":"A1038","pred":"tao:has_database_id","subj":"1038","obj":"Tax:694009"},{"id":"A1039","pred":"tao:has_database_id","subj":"1039","obj":"Tax:694009"},{"id":"A1040","pred":"tao:has_database_id","subj":"1040","obj":"Tax:694009"},{"id":"A1041","pred":"tao:has_database_id","subj":"1041","obj":"Tax:694009"},{"id":"A1042","pred":"tao:has_database_id","subj":"1042","obj":"Tax:9606"},{"id":"A1043","pred":"tao:has_database_id","subj":"1043","obj":"Tax:10090"},{"id":"A1044","pred":"tao:has_database_id","subj":"1044","obj":"Tax:694009"},{"id":"A1045","pred":"tao:has_database_id","subj":"1045","obj":"Tax:9606"},{"id":"A1046","pred":"tao:has_database_id","subj":"1046","obj":"Tax:694009"},{"id":"A1047","pred":"tao:has_database_id","subj":"1047","obj":"Tax:694009"},{"id":"A1048","pred":"tao:has_database_id","subj":"1048","obj":"MESH:C000657245"},{"id":"A1049","pred":"tao:has_database_id","subj":"1049","obj":"MESH:C000657245"},{"id":"A1050","pred":"tao:has_database_id","subj":"1050","obj":"MESH:D054198"},{"id":"A1051","pred":"tao:has_database_id","subj":"1051","obj":"MESH:D007239"},{"id":"A1052","pred":"tao:has_database_id","subj":"1052","obj":"MESH:D008223"},{"id":"A1053","pred":"tao:has_database_id","subj":"1053","obj":"MESH:D007239"},{"id":"A1054","pred":"tao:has_database_id","subj":"1054","obj":"CVCL:5V07"},{"id":"A1055","pred":"tao:has_database_id","subj":"1055","obj":"CVCL:0511"},{"subj":"1037","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1038","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1039","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1040","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1041","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1042","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1043","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1044","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1045","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1046","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1047","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1048","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1049","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1050","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1051","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1052","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1053","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1054","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1055","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T169","span":{"begin":37,"end":44},"obj":"Body_part"},{"id":"T170","span":{"begin":82,"end":89},"obj":"Body_part"},{"id":"T171","span":{"begin":219,"end":223},"obj":"Body_part"},{"id":"T172","span":{"begin":295,"end":302},"obj":"Body_part"},{"id":"T173","span":{"begin":415,"end":422},"obj":"Body_part"},{"id":"T174","span":{"begin":460,"end":464},"obj":"Body_part"},{"id":"T175","span":{"begin":620,"end":628},"obj":"Body_part"},{"id":"T176","span":{"begin":713,"end":721},"obj":"Body_part"},{"id":"T177","span":{"begin":852,"end":857},"obj":"Body_part"},{"id":"T178","span":{"begin":941,"end":948},"obj":"Body_part"},{"id":"T179","span":{"begin":973,"end":978},"obj":"Body_part"},{"id":"T180","span":{"begin":991,"end":999},"obj":"Body_part"},{"id":"T181","span":{"begin":1222,"end":1231},"obj":"Body_part"},{"id":"T182","span":{"begin":1235,"end":1248},"obj":"Body_part"},{"id":"T183","span":{"begin":1249,"end":1253},"obj":"Body_part"},{"id":"T184","span":{"begin":1314,"end":1321},"obj":"Body_part"},{"id":"T185","span":{"begin":1336,"end":1341},"obj":"Body_part"},{"id":"T186","span":{"begin":1345,"end":1349},"obj":"Body_part"},{"id":"T187","span":{"begin":1492,"end":1499},"obj":"Body_part"}],"attributes":[{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma24920"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma83030"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T173","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T175","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T176","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T178","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T179","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T180","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T181","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T182","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T183","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T184","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T185","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T186","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T13","span":{"begin":973,"end":978},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T160","span":{"begin":26,"end":34},"obj":"Disease"},{"id":"T161","span":{"begin":131,"end":149},"obj":"Disease"},{"id":"T162","span":{"begin":140,"end":149},"obj":"Disease"},{"id":"T163","span":{"begin":284,"end":292},"obj":"Disease"},{"id":"T164","span":{"begin":393,"end":401},"obj":"Disease"},{"id":"T165","span":{"begin":441,"end":449},"obj":"Disease"},{"id":"T166","span":{"begin":795,"end":803},"obj":"Disease"},{"id":"T167","span":{"begin":1056,"end":1074},"obj":"Disease"},{"id":"T168","span":{"begin":1065,"end":1074},"obj":"Disease"},{"id":"T169","span":{"begin":1195,"end":1198},"obj":"Disease"},{"id":"T170","span":{"begin":1286,"end":1294},"obj":"Disease"},{"id":"T171","span":{"begin":1343,"end":1358},"obj":"Disease"},{"id":"T173","span":{"begin":1350,"end":1358},"obj":"Disease"},{"id":"T174","span":{"begin":1384,"end":1392},"obj":"Disease"},{"id":"T175","span":{"begin":1505,"end":1509},"obj":"Disease"}],"attributes":[{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A164","pred":"mondo_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A165","pred":"mondo_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A166","pred":"mondo_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A167","pred":"mondo_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A168","pred":"mondo_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A169","pred":"mondo_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/MONDO_0019383"},{"id":"A170","pred":"mondo_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A171","pred":"mondo_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/MONDO_0004095"},{"id":"A172","pred":"mondo_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/MONDO_0015759"},{"id":"A173","pred":"mondo_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/MONDO_0005062"},{"id":"A174","pred":"mondo_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A175","pred":"mondo_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T173","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T175","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T416","span":{"begin":187,"end":189},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T417","span":{"begin":187,"end":189},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T418","span":{"begin":219,"end":223},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T419","span":{"begin":247,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0003358"},{"id":"T420","span":{"begin":278,"end":280},"obj":"http://purl.obolibrary.org/obo/CLO_0002878"},{"id":"T421","span":{"begin":364,"end":372},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T422","span":{"begin":450,"end":455},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T423","span":{"begin":651,"end":652},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T424","span":{"begin":832,"end":837},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T425","span":{"begin":852,"end":857},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T426","span":{"begin":859,"end":861},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T427","span":{"begin":859,"end":861},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T428","span":{"begin":887,"end":888},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T429","span":{"begin":925,"end":926},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T430","span":{"begin":1139,"end":1141},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T431","span":{"begin":1156,"end":1158},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T432","span":{"begin":1216,"end":1221},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T433","span":{"begin":1222,"end":1231},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T434","span":{"begin":1249,"end":1259},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T435","span":{"begin":1329,"end":1333},"obj":"http://purl.obolibrary.org/obo/CLO_0008734"},{"id":"T436","span":{"begin":1329,"end":1333},"obj":"http://purl.obolibrary.org/obo/CLO_0051728"},{"id":"T437","span":{"begin":1334,"end":1341},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T438","span":{"begin":1343,"end":1349},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T439","span":{"begin":1503,"end":1504},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T416","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T417","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T418","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T420","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T421","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T422","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T423","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T424","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T425","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T426","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T427","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T428","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T429","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T430","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T431","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T432","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T433","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T434","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T435","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T184","span":{"begin":37,"end":44},"obj":"Chemical"},{"id":"T185","span":{"begin":82,"end":89},"obj":"Chemical"},{"id":"T186","span":{"begin":187,"end":189},"obj":"Chemical"},{"id":"T187","span":{"begin":247,"end":249},"obj":"Chemical"},{"id":"T188","span":{"begin":295,"end":302},"obj":"Chemical"},{"id":"T189","span":{"begin":415,"end":422},"obj":"Chemical"},{"id":"T190","span":{"begin":620,"end":628},"obj":"Chemical"},{"id":"T191","span":{"begin":859,"end":861},"obj":"Chemical"},{"id":"T192","span":{"begin":941,"end":948},"obj":"Chemical"},{"id":"T193","span":{"begin":1152,"end":1154},"obj":"Chemical"},{"id":"T194","span":{"begin":1314,"end":1321},"obj":"Chemical"},{"id":"T195","span":{"begin":1492,"end":1499},"obj":"Chemical"}],"attributes":[{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A186","pred":"chebi_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A187","pred":"chebi_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/CHEBI_91150"},{"id":"A188","pred":"chebi_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A189","pred":"chebi_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A190","pred":"chebi_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A191","pred":"chebi_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A193","pred":"chebi_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A194","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T184","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T185","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T186","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T190","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T193","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T194","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":1343,"end":1358},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0012191"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"2_test","denotations":[{"id":"32265848-17049691-36511129","span":{"begin":181,"end":185},"obj":"17049691"},{"id":"32265848-23573979-36511130","span":{"begin":198,"end":202},"obj":"23573979"},{"id":"32265848-23573979-36511132","span":{"begin":870,"end":874},"obj":"23573979"},{"id":"32265848-17049691-36511133","span":{"begin":1088,"end":1092},"obj":"17049691"},{"id":"32265848-17049691-36511134","span":{"begin":1406,"end":1410},"obj":"17049691"},{"id":"32265848-22311359-36511135","span":{"begin":1426,"end":1430},"obj":"22311359"}],"attributes":[{"subj":"32265848-17049691-36511129","pred":"source","obj":"2_test"},{"subj":"32265848-23573979-36511130","pred":"source","obj":"2_test"},{"subj":"32265848-23573979-36511132","pred":"source","obj":"2_test"},{"subj":"32265848-17049691-36511133","pred":"source","obj":"2_test"},{"subj":"32265848-17049691-36511134","pred":"source","obj":"2_test"},{"subj":"32265848-22311359-36511135","pred":"source","obj":"2_test"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T192","span":{"begin":0,"end":204},"obj":"Sentence"},{"id":"T193","span":{"begin":205,"end":581},"obj":"Sentence"},{"id":"T194","span":{"begin":582,"end":876},"obj":"Sentence"},{"id":"T195","span":{"begin":877,"end":1094},"obj":"Sentence"},{"id":"T196","span":{"begin":1095,"end":1525},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T192","pred":"source","obj":"LitCovid-sentences"},{"subj":"T193","pred":"source","obj":"LitCovid-sentences"},{"subj":"T194","pred":"source","obj":"LitCovid-sentences"},{"subj":"T195","pred":"source","obj":"LitCovid-sentences"},{"subj":"T196","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T513","span":{"begin":26,"end":34},"obj":"SP_10"},{"id":"T514","span":{"begin":35,"end":44},"obj":"PG_1"},{"id":"T515","span":{"begin":80,"end":89},"obj":"PG_1"},{"id":"T516","span":{"begin":95,"end":106},"obj":"CHEBI:60816;CHEBI:60816"},{"id":"T517","span":{"begin":131,"end":139},"obj":"SP_10"},{"id":"T518","span":{"begin":212,"end":218},"obj":"NCBITaxon:6960"},{"id":"T519","span":{"begin":224,"end":233},"obj":"GO:0010467"},{"id":"T520","span":{"begin":256,"end":269},"obj":"GO:0005576"},{"id":"T521","span":{"begin":270,"end":276},"obj":"SO:0000417"},{"id":"T522","span":{"begin":284,"end":292},"obj":"SP_10"},{"id":"T523","span":{"begin":293,"end":302},"obj":"PG_1"},{"id":"T524","span":{"begin":335,"end":345},"obj":"GO:0042571"},{"id":"T525","span":{"begin":393,"end":401},"obj":"SP_10"},{"id":"T526","span":{"begin":402,"end":412},"obj":"GO:0010467"},{"id":"T527","span":{"begin":413,"end":422},"obj":"PG_1"},{"id":"T528","span":{"begin":441,"end":449},"obj":"SP_10"},{"id":"T529","span":{"begin":450,"end":455},"obj":"SP_6;NCBITaxon:9606"},{"id":"T530","span":{"begin":460,"end":470},"obj":"SP_5"},{"id":"T531","span":{"begin":713,"end":721},"obj":"GO:0042571"},{"id":"T532","span":{"begin":749,"end":759},"obj":"GO:0042571"},{"id":"T533","span":{"begin":782,"end":786},"obj":"NCBITaxon:10088"},{"id":"T534","span":{"begin":795,"end":803},"obj":"SP_10"},{"id":"T535","span":{"begin":832,"end":837},"obj":"NCBITaxon:10239"},{"id":"T536","span":{"begin":852,"end":857},"obj":"UBERON:0000170"},{"id":"T537","span":{"begin":939,"end":948},"obj":"PG_1"},{"id":"T538","span":{"begin":973,"end":978},"obj":"UBERON:0001977"},{"id":"T539","span":{"begin":983,"end":990},"obj":"UBERON:0000912"},{"id":"T540","span":{"begin":991,"end":999},"obj":"GO:0042571"},{"id":"T541","span":{"begin":1037,"end":1047},"obj":"GO:0042571"},{"id":"T542","span":{"begin":1056,"end":1064},"obj":"SP_10"},{"id":"T543","span":{"begin":1178,"end":1182},"obj":"G_3;PG_10;PR:000003622"},{"id":"T544","span":{"begin":1216,"end":1221},"obj":"SP_6;NCBITaxon:9606"},{"id":"T545","span":{"begin":1222,"end":1231},"obj":"CL:0000576"},{"id":"T546","span":{"begin":1286,"end":1294},"obj":"SP_10"},{"id":"T547","span":{"begin":1295,"end":1305},"obj":"GO:0010467"},{"id":"T548","span":{"begin":1306,"end":1311},"obj":"NCBITaxon:10239"},{"id":"T549","span":{"begin":1312,"end":1321},"obj":"PG_1"},{"id":"T550","span":{"begin":1334,"end":1341},"obj":"CL:0000236"},{"id":"T551","span":{"begin":1343,"end":1349},"obj":"CL:0000236"},{"id":"T552","span":{"begin":1384,"end":1392},"obj":"SP_10"},{"id":"T553","span":{"begin":1490,"end":1499},"obj":"PG_1"},{"id":"T554","span":{"begin":1505,"end":1509},"obj":"SP_10"},{"id":"T44997","span":{"begin":26,"end":34},"obj":"SP_10"},{"id":"T88305","span":{"begin":35,"end":44},"obj":"PG_1"},{"id":"T17464","span":{"begin":80,"end":89},"obj":"PG_1"},{"id":"T11219","span":{"begin":95,"end":106},"obj":"CHEBI:60816;CHEBI:60816"},{"id":"T28280","span":{"begin":131,"end":139},"obj":"SP_10"},{"id":"T55510","span":{"begin":212,"end":218},"obj":"NCBITaxon:6960"},{"id":"T48550","span":{"begin":224,"end":233},"obj":"GO:0010467"},{"id":"T6400","span":{"begin":256,"end":269},"obj":"GO:0005576"},{"id":"T82107","span":{"begin":270,"end":276},"obj":"SO:0000417"},{"id":"T79376","span":{"begin":284,"end":292},"obj":"SP_10"},{"id":"T40036","span":{"begin":293,"end":302},"obj":"PG_1"},{"id":"T30442","span":{"begin":335,"end":345},"obj":"GO:0042571"},{"id":"T88681","span":{"begin":393,"end":401},"obj":"SP_10"},{"id":"T39868","span":{"begin":402,"end":412},"obj":"GO:0010467"},{"id":"T37152","span":{"begin":413,"end":422},"obj":"PG_1"},{"id":"T62328","span":{"begin":441,"end":449},"obj":"SP_10"},{"id":"T47566","span":{"begin":450,"end":455},"obj":"SP_6;NCBITaxon:9606"},{"id":"T32795","span":{"begin":460,"end":470},"obj":"SP_5"},{"id":"T18090","span":{"begin":713,"end":721},"obj":"GO:0042571"},{"id":"T57836","span":{"begin":749,"end":759},"obj":"GO:0042571"},{"id":"T88472","span":{"begin":782,"end":786},"obj":"NCBITaxon:10088"},{"id":"T30695","span":{"begin":795,"end":803},"obj":"SP_10"},{"id":"T96452","span":{"begin":832,"end":837},"obj":"NCBITaxon:10239"},{"id":"T59338","span":{"begin":852,"end":857},"obj":"UBERON:0000170"},{"id":"T84830","span":{"begin":939,"end":948},"obj":"PG_1"},{"id":"T4211","span":{"begin":973,"end":978},"obj":"UBERON:0001977"},{"id":"T21928","span":{"begin":983,"end":990},"obj":"UBERON:0000912"},{"id":"T52300","span":{"begin":991,"end":999},"obj":"GO:0042571"},{"id":"T9329","span":{"begin":1037,"end":1047},"obj":"GO:0042571"},{"id":"T92506","span":{"begin":1056,"end":1064},"obj":"SP_10"},{"id":"T24672","span":{"begin":1178,"end":1182},"obj":"G_3;PG_10;PR:000003622"},{"id":"T34596","span":{"begin":1216,"end":1221},"obj":"SP_6;NCBITaxon:9606"},{"id":"T78001","span":{"begin":1222,"end":1231},"obj":"CL:0000576"},{"id":"T51847","span":{"begin":1286,"end":1294},"obj":"SP_10"},{"id":"T5780","span":{"begin":1295,"end":1305},"obj":"GO:0010467"},{"id":"T88105","span":{"begin":1306,"end":1311},"obj":"NCBITaxon:10239"},{"id":"T44559","span":{"begin":1312,"end":1321},"obj":"PG_1"},{"id":"T7143","span":{"begin":1334,"end":1341},"obj":"CL:0000236"},{"id":"T24600","span":{"begin":1343,"end":1349},"obj":"CL:0000236"},{"id":"T5374","span":{"begin":1384,"end":1392},"obj":"SP_10"},{"id":"T12423","span":{"begin":1490,"end":1499},"obj":"PG_1"},{"id":"T58430","span":{"begin":1505,"end":1509},"obj":"SP_10"}],"attributes":[{"subj":"T513","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T514","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T515","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T516","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T517","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T518","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T519","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T520","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T521","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T522","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T523","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T524","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T525","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T526","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T527","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T528","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T529","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T530","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T531","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T532","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T533","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T534","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T535","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T536","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T537","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T538","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T539","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T540","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T541","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T542","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T543","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T544","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T545","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T546","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T547","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T548","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T549","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T550","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T551","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T552","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T553","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T554","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T44997","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88305","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T17464","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T11219","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T28280","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55510","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48550","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6400","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T82107","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T79376","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T40036","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30442","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88681","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T39868","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T37152","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T62328","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T47566","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T32795","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T18090","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T57836","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88472","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T30695","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T96452","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T59338","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T84830","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T4211","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T21928","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T52300","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9329","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T92506","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24672","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34596","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T78001","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T51847","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T5780","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T88105","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T44559","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T7143","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24600","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T5374","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T12423","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T58430","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93c7","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93e1ec"},{"id":"LitCovid-PD-UBERON","color":"#ecdd93"},{"id":"LitCovid-PD-MONDO","color":"#c393ec"},{"id":"LitCovid-PD-CLO","color":"#93eca9"},{"id":"LitCovid-PD-CHEBI","color":"#ec9396"},{"id":"LitCovid-PD-HP","color":"#93b0ec"},{"id":"2_test","color":"#caec93"},{"id":"LitCovid-sentences","color":"#ec93e4"},{"id":"LitCovid-PMC-OGER-BB","color":"#93ecd9"}]}]}}