PMC:7105881 / 31627-33152
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1037 | 1178-1182 | Gene | denotes | ACE2 | Gene:59272 |
| 1038 | 26-34 | Species | denotes | SARS-CoV | Tax:694009 |
| 1039 | 284-292 | Species | denotes | SARS-CoV | Tax:694009 |
| 1040 | 393-401 | Species | denotes | SARS-CoV | Tax:694009 |
| 1041 | 441-449 | Species | denotes | SARS-CoV | Tax:694009 |
| 1042 | 450-455 | Species | denotes | human | Tax:9606 |
| 1043 | 782-786 | Species | denotes | mice | Tax:10090 |
| 1044 | 795-803 | Species | denotes | SARS-CoV | Tax:694009 |
| 1045 | 1216-1221 | Species | denotes | human | Tax:9606 |
| 1046 | 1286-1294 | Species | denotes | SARS-CoV | Tax:694009 |
| 1047 | 1384-1392 | Species | denotes | SARS-CoV | Tax:694009 |
| 1048 | 131-149 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1049 | 1056-1074 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1050 | 1235-1248 | Disease | denotes | lymphoblastic | MESH:D054198 |
| 1051 | 1260-1268 | Disease | denotes | infected | MESH:D007239 |
| 1052 | 1350-1358 | Disease | denotes | lymphoma | MESH:D008223 |
| 1053 | 1365-1373 | Disease | denotes | infected | MESH:D007239 |
| 1054 | 278-282 | CellLine | denotes | EC-S | CVCL:5V07 |
| 1055 | 1329-1335 | CellLine | denotes | Raji B | CVCL:0511 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T169 | 37-44 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T170 | 82-89 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T171 | 219-223 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T172 | 295-302 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T173 | 415-422 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T174 | 460-464 | Body_part | denotes | palm | http://purl.org/sig/ont/fma/fma24920 |
| T175 | 620-628 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T176 | 713-721 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T177 | 852-857 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T178 | 941-948 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T179 | 973-978 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T180 | 991-999 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T181 | 1222-1231 | Body_part | denotes | monocytic | http://purl.org/sig/ont/fma/fma62864 |
| T182 | 1235-1248 | Body_part | denotes | lymphoblastic | http://purl.org/sig/ont/fma/fma83030 |
| T183 | 1249-1253 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T184 | 1314-1321 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T185 | 1336-1341 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T186 | 1345-1349 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T187 | 1492-1499 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T13 | 973-978 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T160 | 26-34 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T161 | 131-149 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T162 | 140-149 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T163 | 284-292 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T164 | 393-401 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T165 | 441-449 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T166 | 795-803 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T167 | 1056-1074 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T168 | 1065-1074 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T169 | 1195-1198 | Disease | denotes | ADE | http://purl.obolibrary.org/obo/MONDO_0019383 |
| T170 | 1286-1294 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T171 | 1343-1358 | Disease | denotes | B-cell lymphoma | http://purl.obolibrary.org/obo/MONDO_0004095|http://purl.obolibrary.org/obo/MONDO_0015759 |
| T173 | 1350-1358 | Disease | denotes | lymphoma | http://purl.obolibrary.org/obo/MONDO_0005062 |
| T174 | 1384-1392 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T175 | 1505-1509 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T416 | 187-189 | http://purl.obolibrary.org/obo/CLO_0001022 | denotes | Li |
| T417 | 187-189 | http://purl.obolibrary.org/obo/CLO_0007314 | denotes | Li |
| T418 | 219-223 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T419 | 247-249 | http://purl.obolibrary.org/obo/CLO_0003358 | denotes | FL |
| T420 | 278-280 | http://purl.obolibrary.org/obo/CLO_0002878 | denotes | EC |
| T421 | 364-372 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T422 | 450-455 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T423 | 651-652 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T424 | 832-837 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T425 | 852-857 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T426 | 859-861 | http://purl.obolibrary.org/obo/CLO_0001022 | denotes | Li |
| T427 | 859-861 | http://purl.obolibrary.org/obo/CLO_0007314 | denotes | Li |
| T428 | 887-888 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T429 | 925-926 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T430 | 1139-1141 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T431 | 1156-1158 | http://purl.obolibrary.org/obo/CLO_0052676 | denotes | Fc |
| T432 | 1216-1221 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T433 | 1222-1231 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytic |
| T434 | 1249-1259 | http://purl.obolibrary.org/obo/CLO_0000031 | denotes | cell lines |
| T435 | 1329-1333 | http://purl.obolibrary.org/obo/CLO_0008734 | denotes | Raji |
| T436 | 1329-1333 | http://purl.obolibrary.org/obo/CLO_0051728 | denotes | Raji |
| T437 | 1334-1341 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T438 | 1343-1349 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B-cell |
| T439 | 1503-1504 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T184 | 37-44 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T185 | 82-89 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T186 | 187-189 | Chemical | denotes | Li | http://purl.obolibrary.org/obo/CHEBI_30145 |
| T187 | 247-249 | Chemical | denotes | FL | http://purl.obolibrary.org/obo/CHEBI_91150 |
| T188 | 295-302 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T189 | 415-422 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T190 | 620-628 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T191 | 859-861 | Chemical | denotes | Li | http://purl.obolibrary.org/obo/CHEBI_30145 |
| T192 | 941-948 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T193 | 1152-1154 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T194 | 1314-1321 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T195 | 1492-1499 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T11 | 1343-1358 | Phenotype | denotes | B-cell lymphoma | http://purl.obolibrary.org/obo/HP_0012191 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32265848-17049691-36511129 | 181-185 | 17049691 | denotes | 2007 |
| 32265848-23573979-36511130 | 198-202 | 23573979 | denotes | 2013 |
| 32265848-23573979-36511132 | 870-874 | 23573979 | denotes | 2013 |
| 32265848-17049691-36511133 | 1088-1092 | 17049691 | denotes | 2007 |
| 32265848-17049691-36511134 | 1406-1410 | 17049691 | denotes | 2007 |
| 32265848-22311359-36511135 | 1426-1430 | 22311359 | denotes | 2012 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T192 | 0-204 | Sentence | denotes | Subunit vaccines based on SARS-CoV S protein, including full-length or trimeric S protein, are immunogenic with protection against SARS-CoV infection (He et al., 2006a; Kam et al., 2007; Li et al., 2013). |
| T193 | 205-581 | Sentence | denotes | Either insect cell-expressed full-length (FL-S) or extracellular domain (EC-S) SARS-CoV S protein developed high-titer S-specific antibodies with neutralizing activity against pseudotyped SARS-CoV expressing S protein of representative SARS-CoV human and palm civet strains (Tor2, GD03, and SZ3) isolated during the 2002 and 2003 or 2003 and 2004 outbreaks (He et al., 2006a). |
| T194 | 582-876 | Sentence | denotes | In addition, full-length S-ectodomain proteins fused with or without a foldon trimeric motif (S or S-foldon) could elicit specific antibody responses and neutralizing antibodies, protecting immunized mice against SARS-CoV challenge with undetectable virus titers in the lungs (Li et al., 2013). |
| T195 | 877-1094 | Sentence | denotes | Moreover, a subunit vaccine (triSpike) based on a full-length S protein trimer induced specific serum and mucosal antibody responses and efficient neutralizing antibodies against SARS-CoV infection (Kam et al., 2007). |
| T196 | 1095-1525 | Sentence | denotes | Nevertheless, this vaccine also resulted in Fcγ receptor II (FcγRII)-dependent and ACE2-independent ADE, particularly in human monocytic or lymphoblastic cell lines infected with pseudotyped SARS-CoV expressing viral S protein, or in Raji B cells (B-cell lymphoma line) infected with live SARS-CoV (Kam et al., 2007; Jaume et al., 2012), raising significant concerns over the use of full-length S protein as a SARS vaccine target. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T513 | 26-34 | SP_10 | denotes | SARS-CoV |
| T514 | 35-44 | PG_1 | denotes | S protein |
| T515 | 80-89 | PG_1 | denotes | S protein |
| T516 | 95-106 | CHEBI:60816;CHEBI:60816 | denotes | immunogenic |
| T517 | 131-139 | SP_10 | denotes | SARS-CoV |
| T518 | 212-218 | NCBITaxon:6960 | denotes | insect |
| T519 | 224-233 | GO:0010467 | denotes | expressed |
| T520 | 256-269 | GO:0005576 | denotes | extracellular |
| T521 | 270-276 | SO:0000417 | denotes | domain |
| T522 | 284-292 | SP_10 | denotes | SARS-CoV |
| T523 | 293-302 | PG_1 | denotes | S protein |
| T524 | 335-345 | GO:0042571 | denotes | antibodies |
| T525 | 393-401 | SP_10 | denotes | SARS-CoV |
| T526 | 402-412 | GO:0010467 | denotes | expressing |
| T527 | 413-422 | PG_1 | denotes | S protein |
| T528 | 441-449 | SP_10 | denotes | SARS-CoV |
| T529 | 450-455 | SP_6;NCBITaxon:9606 | denotes | human |
| T530 | 460-470 | SP_5 | denotes | palm civet |
| T531 | 713-721 | GO:0042571 | denotes | antibody |
| T532 | 749-759 | GO:0042571 | denotes | antibodies |
| T533 | 782-786 | NCBITaxon:10088 | denotes | mice |
| T534 | 795-803 | SP_10 | denotes | SARS-CoV |
| T535 | 832-837 | NCBITaxon:10239 | denotes | virus |
| T536 | 852-857 | UBERON:0000170 | denotes | lungs |
| T537 | 939-948 | PG_1 | denotes | S protein |
| T538 | 973-978 | UBERON:0001977 | denotes | serum |
| T539 | 983-990 | UBERON:0000912 | denotes | mucosal |
| T540 | 991-999 | GO:0042571 | denotes | antibody |
| T541 | 1037-1047 | GO:0042571 | denotes | antibodies |
| T542 | 1056-1064 | SP_10 | denotes | SARS-CoV |
| T543 | 1178-1182 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T544 | 1216-1221 | SP_6;NCBITaxon:9606 | denotes | human |
| T545 | 1222-1231 | CL:0000576 | denotes | monocytic |
| T546 | 1286-1294 | SP_10 | denotes | SARS-CoV |
| T547 | 1295-1305 | GO:0010467 | denotes | expressing |
| T548 | 1306-1311 | NCBITaxon:10239 | denotes | viral |
| T549 | 1312-1321 | PG_1 | denotes | S protein |
| T550 | 1334-1341 | CL:0000236 | denotes | B cells |
| T551 | 1343-1349 | CL:0000236 | denotes | B-cell |
| T552 | 1384-1392 | SP_10 | denotes | SARS-CoV |
| T553 | 1490-1499 | PG_1 | denotes | S protein |
| T554 | 1505-1509 | SP_10 | denotes | SARS |
| T44997 | 26-34 | SP_10 | denotes | SARS-CoV |
| T88305 | 35-44 | PG_1 | denotes | S protein |
| T17464 | 80-89 | PG_1 | denotes | S protein |
| T11219 | 95-106 | CHEBI:60816;CHEBI:60816 | denotes | immunogenic |
| T28280 | 131-139 | SP_10 | denotes | SARS-CoV |
| T55510 | 212-218 | NCBITaxon:6960 | denotes | insect |
| T48550 | 224-233 | GO:0010467 | denotes | expressed |
| T6400 | 256-269 | GO:0005576 | denotes | extracellular |
| T82107 | 270-276 | SO:0000417 | denotes | domain |
| T79376 | 284-292 | SP_10 | denotes | SARS-CoV |
| T40036 | 293-302 | PG_1 | denotes | S protein |
| T30442 | 335-345 | GO:0042571 | denotes | antibodies |
| T88681 | 393-401 | SP_10 | denotes | SARS-CoV |
| T39868 | 402-412 | GO:0010467 | denotes | expressing |
| T37152 | 413-422 | PG_1 | denotes | S protein |
| T62328 | 441-449 | SP_10 | denotes | SARS-CoV |
| T47566 | 450-455 | SP_6;NCBITaxon:9606 | denotes | human |
| T32795 | 460-470 | SP_5 | denotes | palm civet |
| T18090 | 713-721 | GO:0042571 | denotes | antibody |
| T57836 | 749-759 | GO:0042571 | denotes | antibodies |
| T88472 | 782-786 | NCBITaxon:10088 | denotes | mice |
| T30695 | 795-803 | SP_10 | denotes | SARS-CoV |
| T96452 | 832-837 | NCBITaxon:10239 | denotes | virus |
| T59338 | 852-857 | UBERON:0000170 | denotes | lungs |
| T84830 | 939-948 | PG_1 | denotes | S protein |
| T4211 | 973-978 | UBERON:0001977 | denotes | serum |
| T21928 | 983-990 | UBERON:0000912 | denotes | mucosal |
| T52300 | 991-999 | GO:0042571 | denotes | antibody |
| T9329 | 1037-1047 | GO:0042571 | denotes | antibodies |
| T92506 | 1056-1064 | SP_10 | denotes | SARS-CoV |
| T24672 | 1178-1182 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T34596 | 1216-1221 | SP_6;NCBITaxon:9606 | denotes | human |
| T78001 | 1222-1231 | CL:0000576 | denotes | monocytic |
| T51847 | 1286-1294 | SP_10 | denotes | SARS-CoV |
| T5780 | 1295-1305 | GO:0010467 | denotes | expressing |
| T88105 | 1306-1311 | NCBITaxon:10239 | denotes | viral |
| T44559 | 1312-1321 | PG_1 | denotes | S protein |
| T7143 | 1334-1341 | CL:0000236 | denotes | B cells |
| T24600 | 1343-1349 | CL:0000236 | denotes | B-cell |
| T5374 | 1384-1392 | SP_10 | denotes | SARS-CoV |
| T12423 | 1490-1499 | PG_1 | denotes | S protein |
| T58430 | 1505-1509 | SP_10 | denotes | SARS |