PMC:7103735 / 35554-36386 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7103735","sourcedb":"PMC","sourceid":"7103735","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7103735","text":"CoVs are believed to have existed for \u003e6000 years. Molecular clock analysis enables us to deduce the time of emergence or cross-species transmission of some HCoVs. Surprisingly, the highly pathogenic SARS-CoV and MERS-CoV are thought to emerge in the last 30 years [56]. Although NL63 and HKU1 of low pathogenicity were isolated in the post-SARS era, their time of emergence was earlier than the other two highly pathogenic viruses. Whereas NL63 emerged \u003e500 years ago [57], the origin of HKU1 dated back to the 1950s. In other words, SARS-CoV and MERS-CoV represent newcomers that are striving to adapt to humans, whereas other community-acquired HCoVs including NL63 and HKU1 are better adapted. The results of molecular dating of HCoVs suggest that attenuation might be favoured during evolution when host adaptation takes 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