PMC:7079563 / 20188-21435 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7079563","sourcedb":"PMC","sourceid":"7079563","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7079563","text":"3.3 Origin of 2019-nCoV\nThe epidemiological investigation of early cases of 2019-nCoV pneumonia showed that many cases had been exposed to the Huanan Seafood Market in Wuhan [2,24,20]. In addition, 33 of the 585 environmental samples from Huanan Seafood Market were positive for 2019-nCoV; however, that market was trading a variety of live animals, such as hedgehog, badger, snake, and bird (turtledoves), probably pangolin, but not bats [24,30]. Thus, bats are less likely to have direct contact with human, and direct transmission of the virus from bat to human is unlikely [1]. Indeed, SARS-CoV and MERS-CoV originated from bats, the natural reservoir, but transmitted to humans via intermediate host civets and camels, respectively. Therefore, 2019-nCoV may also originate from bat but was then transmitted to humans via an intermediate host in the market [[31], [32], [33], [34], [35]]. Currently, 2019-nCoV has been isolated from pangolins and it was found that the genomic seuqence of the isolated strain had 99% identity with that of currently 2019-nCoV infected humans. It has been proposed that the transmission and evolution path of 2019-nCoV was from bat-CoV to pangolins (the intermediate hosts), from where it infected humans 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