PMC:7074424 / 25765-26189 JSONTXT

{"project":"2_test","denotations":[{"id":"32201449-24568342-47217135","span":{"begin":12,"end":14},"obj":"24568342"},{"id":"32201449-20527968-47217136","span":{"begin":316,"end":318},"obj":"20527968"},{"id":"T60755","span":{"begin":12,"end":14},"obj":"24568342"},{"id":"T48833","span":{"begin":316,"end":318},"obj":"20527968"}],"text":"4OVZ, 4OWZ.[31] Through in silico approach, another new lead was identified (6577871) which was further optimized, and compound 15h (S configuration, enzyme IC50 =0.56 μM, antiviral EC50 =9.1 μM) and 15g (R configuration, enzyme IC50 =0.32 μM; antiviral EC50 =9.1 μM) were found to be the most important inhibitors.[32] The crystallized structural details of these interactions can be visualized in the PDB database (PDB ID:"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T797","span":{"begin":304,"end":314},"obj":"CHEBI:35222;CHEBI:35222"}],"text":"4OVZ, 4OWZ.[31] Through in silico approach, another new lead was identified (6577871) which was further optimized, and compound 15h (S configuration, enzyme IC50 =0.56 μM, antiviral EC50 =9.1 μM) and 15g (R configuration, enzyme IC50 =0.32 μM; antiviral EC50 =9.1 μM) were found to be the most important inhibitors.[32] The crystallized structural details of these interactions can be visualized in the PDB database (PDB ID:"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T327","span":{"begin":172,"end":181},"obj":"Chemical"},{"id":"T328","span":{"begin":244,"end":253},"obj":"Chemical"},{"id":"T329","span":{"begin":304,"end":314},"obj":"Chemical"},{"id":"T330","span":{"begin":421,"end":423},"obj":"Chemical"}],"attributes":[{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A328","pred":"chebi_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A329","pred":"chebi_id","subj":"T329","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A330","pred":"chebi_id","subj":"T330","obj":"http://purl.obolibrary.org/obo/CHEBI_141439"}],"text":"4OVZ, 4OWZ.[31] Through in silico approach, another new lead was identified (6577871) which was further optimized, and compound 15h (S configuration, enzyme IC50 =0.56 μM, antiviral EC50 =9.1 μM) and 15g (R configuration, enzyme IC50 =0.32 μM; antiviral EC50 =9.1 μM) were found to be the most important inhibitors.[32] The crystallized structural details of these interactions can be visualized in the PDB database (PDB ID:"}

{"project":"LitCovid-sentences","denotations":[{"id":"T151","span":{"begin":0,"end":424},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4OVZ, 4OWZ.[31] Through in silico approach, another new lead was identified (6577871) which was further optimized, and compound 15h (S configuration, enzyme IC50 =0.56 μM, antiviral EC50 =9.1 μM) and 15g (R configuration, enzyme IC50 =0.32 μM; antiviral EC50 =9.1 μM) were found to be the most important inhibitors.[32] The crystallized structural details of these interactions can be visualized in the PDB database (PDB ID:"}