PMC:7074424 / 25765-26189 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7074424","sourcedb":"PMC","sourceid":"7074424","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7074424","text":"4OVZ, 4OWZ.[31] Through in silico approach, another new lead was identified (6577871) which was further optimized, and compound 15h (S configuration, enzyme IC50 =0.56 μM, antiviral EC50 =9.1 μM) and 15g (R configuration, enzyme IC50 =0.32 μM; antiviral EC50 =9.1 μM) were found to be the most important inhibitors.[32] The crystallized structural details of these interactions can be visualized in the PDB database (PDB ID:","tracks":[{"project":"2_test","denotations":[{"id":"32201449-24568342-47217135","span":{"begin":12,"end":14},"obj":"24568342"},{"id":"32201449-20527968-47217136","span":{"begin":316,"end":318},"obj":"20527968"},{"id":"T60755","span":{"begin":12,"end":14},"obj":"24568342"},{"id":"T48833","span":{"begin":316,"end":318},"obj":"20527968"}],"attributes":[{"subj":"32201449-24568342-47217135","pred":"source","obj":"2_test"},{"subj":"32201449-20527968-47217136","pred":"source","obj":"2_test"},{"subj":"T60755","pred":"source","obj":"2_test"},{"subj":"T48833","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T797","span":{"begin":304,"end":314},"obj":"CHEBI:35222;CHEBI:35222"}],"attributes":[{"subj":"T797","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T327","span":{"begin":172,"end":181},"obj":"Chemical"},{"id":"T328","span":{"begin":244,"end":253},"obj":"Chemical"},{"id":"T329","span":{"begin":304,"end":314},"obj":"Chemical"},{"id":"T330","span":{"begin":421,"end":423},"obj":"Chemical"}],"attributes":[{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A328","pred":"chebi_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A329","pred":"chebi_id","subj":"T329","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A330","pred":"chebi_id","subj":"T330","obj":"http://purl.obolibrary.org/obo/CHEBI_141439"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T151","span":{"begin":0,"end":424},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T151","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#baec93","default":true},{"id":"LitCovid-PMC-OGER-BB","color":"#ec93d4"},{"id":"LitCovid-PD-CHEBI","color":"#93ecea"},{"id":"LitCovid-sentences","color":"#ecd093"}]}]}}