PMC:7074424 / 13627-14015 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"306","span":{"begin":107,"end":112},"obj":"Gene"},{"id":"307","span":{"begin":250,"end":255},"obj":"Gene"},{"id":"308","span":{"begin":294,"end":299},"obj":"Gene"},{"id":"309","span":{"begin":303,"end":308},"obj":"Gene"},{"id":"310","span":{"begin":337,"end":342},"obj":"Gene"},{"id":"314","span":{"begin":49,"end":57},"obj":"Species"}],"attributes":[{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"Gene:59272"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"Gene:59272"},{"id":"A308","pred":"tao:has_database_id","subj":"308","obj":"Gene:59272"},{"id":"A309","pred":"tao:has_database_id","subj":"309","obj":"Gene:1803"},{"id":"A310","pred":"tao:has_database_id","subj":"310","obj":"Gene:103231639"},{"id":"A314","pred":"tao:has_database_id","subj":"314","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"2_test","denotations":[{"id":"32201449-14715271-47217051","span":{"begin":73,"end":75},"obj":"14715271"},{"id":"32201449-19198616-47217052","span":{"begin":257,"end":259},"obj":"19198616"},{"id":"T78902","span":{"begin":73,"end":75},"obj":"14715271"},{"id":"T49316","span":{"begin":257,"end":259},"obj":"19198616"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T455","span":{"begin":49,"end":57},"obj":"SP_10"},{"id":"T454","span":{"begin":107,"end":112},"obj":"G_3;PG_10;PR:000003622"},{"id":"T453","span":{"begin":250,"end":255},"obj":"G_3;PG_10;PR:000003622"},{"id":"T452","span":{"begin":268,"end":274},"obj":"SO:0000417"},{"id":"T451","span":{"begin":294,"end":299},"obj":"G_3;PG_10;PR:000003622"},{"id":"T450","span":{"begin":303,"end":308},"obj":"PG_7;PR:000001341"},{"id":"T449","span":{"begin":337,"end":342},"obj":"G_3;PG_10;PR:000003622"},{"id":"T448","span":{"begin":343,"end":351},"obj":"GO:0042571"},{"id":"T447","span":{"begin":360,"end":365},"obj":"NCBITaxon:10239;GO:0035376"},{"id":"T446","span":{"begin":366,"end":371},"obj":"GO:0035376"},{"id":"T445","span":{"begin":376,"end":387},"obj":"GO:0006260"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T122","span":{"begin":33,"end":44},"obj":"Body_part"},{"id":"T123","span":{"begin":64,"end":71},"obj":"Body_part"},{"id":"T124","span":{"begin":343,"end":351},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid_AGAC","denotations":[{"id":"p17313s14","span":{"begin":228,"end":244},"obj":"MPA"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":49,"end":57},"obj":"Disease"},{"id":"T73","span":{"begin":49,"end":53},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T134","span":{"begin":73,"end":75},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T135","span":{"begin":236,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T136","span":{"begin":254,"end":259},"obj":"http://purl.obolibrary.org/obo/CLO_0001196"},{"id":"T137","span":{"begin":265,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T125","span":{"begin":33,"end":44},"obj":"Chemical"},{"id":"T126","span":{"begin":33,"end":38},"obj":"Chemical"},{"id":"T127","span":{"begin":39,"end":44},"obj":"Chemical"},{"id":"T128","span":{"begin":64,"end":71},"obj":"Chemical"},{"id":"T129","span":{"begin":303,"end":306},"obj":"Chemical"}],"attributes":[{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_34680"},{"id":"A130","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_60069"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}

{"project":"LitCovid-sentences","denotations":[{"id":"T93","span":{"begin":167,"end":331},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication "}