PMC:7074424 / 13627-14015 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7074424","sourcedb":"PMC","sourceid":"7074424","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7074424","text":"nteract with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role. If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host. Anti-ACE-2 antibody blocked viral entry and replication 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