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LitCovid-PubTator

LitCovid-PD-FMA-UBERON

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T44","span":{"begin":362,"end":371},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T45","span":{"begin":362,"end":371},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T46","span":{"begin":648,"end":663},"obj":"http://purl.obolibrary.org/obo/GO_0061025"},{"id":"T47","span":{"begin":704,"end":728},"obj":"http://purl.obolibrary.org/obo/GO_0050819"},{"id":"T48","span":{"begin":832,"end":841},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T49","span":{"begin":1059,"end":1066},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T50","span":{"begin":1087,"end":1104},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T51","span":{"begin":1087,"end":1104},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T52","span":{"begin":1592,"end":1604},"obj":"http://purl.obolibrary.org/obo/GO_0000003"},{"id":"T53","span":{"begin":1645,"end":1658},"obj":"http://purl.obolibrary.org/obo/GO_0071897"},{"id":"T54","span":{"begin":1649,"end":1658},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T55","span":{"begin":1791,"end":1797},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"Status Drugs Action mode Anti-infective mechanism Target diseases Ref.\nApproved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85]\nApproved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82]\nExperimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS\n(A wide array of RNA viruses) [76, 88, 89]\nInvestigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91]\nApproved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94]\nApproved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96]\nApproved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97]\nApproved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98]\nInvestigational Favipiravir (T-705) Nucleoside analog: Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101]\nApproved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104]"}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T167","span":{"begin":0,"end":70},"obj":"Sentence"},{"id":"T168","span":{"begin":71,"end":250},"obj":"Sentence"},{"id":"T169","span":{"begin":251,"end":418},"obj":"Sentence"},{"id":"T170","span":{"begin":419,"end":532},"obj":"Sentence"},{"id":"T171","span":{"begin":533,"end":575},"obj":"Sentence"},{"id":"T172","span":{"begin":576,"end":760},"obj":"Sentence"},{"id":"T173","span":{"begin":761,"end":943},"obj":"Sentence"},{"id":"T174","span":{"begin":944,"end":1150},"obj":"Sentence"},{"id":"T175","span":{"begin":1151,"end":1285},"obj":"Sentence"},{"id":"T176","span":{"begin":1286,"end":1458},"obj":"Sentence"},{"id":"T177","span":{"begin":1459,"end":1513},"obj":"Sentence"},{"id":"T178","span":{"begin":1514,"end":1692},"obj":"Sentence"},{"id":"T179","span":{"begin":1693,"end":2002},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Status Drugs Action mode Anti-infective mechanism Target diseases Ref.\nApproved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85]\nApproved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82]\nExperimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS\n(A wide array of RNA viruses) [76, 88, 89]\nInvestigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91]\nApproved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94]\nApproved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96]\nApproved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97]\nApproved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98]\nInvestigational Favipiravir (T-705) Nucleoside analog: Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101]\nApproved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104]"}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T51","span":{"begin":392,"end":410},"obj":"Phenotype"}],"attributes":[{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0002960"}],"text":"Status Drugs Action mode Anti-infective mechanism Target diseases Ref.\nApproved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85]\nApproved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82]\nExperimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS\n(A wide array of RNA viruses) [76, 88, 89]\nInvestigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91]\nApproved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94]\nApproved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96]\nApproved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97]\nApproved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98]\nInvestigational Favipiravir (T-705) Nucleoside analog: Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101]\nApproved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104]"}

2_test

{"project":"2_test","denotations":[{"id":"32169119-12662125-70132253","span":{"begin":244,"end":246},"obj":"12662125"},{"id":"32169119-31900204-70132253","span":{"begin":244,"end":246},"obj":"31900204"},{"id":"32169119-14985565-70132253","span":{"begin":244,"end":246},"obj":"14985565"},{"id":"32169119-14592603-70132254","span":{"begin":412,"end":414},"obj":"14592603"},{"id":"32169119-16115318-70132254","span":{"begin":412,"end":414},"obj":"16115318"},{"id":"32169119-25727221-70132254","span":{"begin":412,"end":414},"obj":"25727221"},{"id":"32169119-32020029-70132254","span":{"begin":412,"end":414},"obj":"32020029"},{"id":"32169119-29511076-70132255","span":{"begin":564,"end":566},"obj":"29511076"},{"id":"32169119-30987343-70132256","span":{"begin":568,"end":570},"obj":"30987343"},{"id":"32169119-31142680-70132257","span":{"begin":572,"end":574},"obj":"31142680"},{"id":"32169119-18220789-70132258","span":{"begin":753,"end":755},"obj":"18220789"},{"id":"32169119-26346967-70132259","span":{"begin":757,"end":759},"obj":"26346967"},{"id":"32169119-30215672-70132260","span":{"begin":937,"end":939},"obj":"30215672"},{"id":"32169119-15018130-70132260","span":{"begin":937,"end":939},"obj":"15018130"},{"id":"32169119-24811411-70132261","span":{"begin":1147,"end":1149},"obj":"24811411"},{"id":"32169119-29896665-70132262","span":{"begin":1282,"end":1284},"obj":"29896665"},{"id":"32169119-29678260-70132263","span":{"begin":1455,"end":1457},"obj":"29678260"},{"id":"32169119-24084488-70132264","span":{"begin":1685,"end":1687},"obj":"24084488"},{"id":"32169119-25108173-70132265","span":{"begin":1994,"end":1997},"obj":"25108173"},{"id":"32169119-25451075-70132265","span":{"begin":1994,"end":1997},"obj":"25451075"},{"id":"32169119-27095301-70132265","span":{"begin":1994,"end":1997},"obj":"27095301"}],"text":"Status Drugs Action mode Anti-infective mechanism Target diseases Ref.\nApproved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85]\nApproved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82]\nExperimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS\n(A wide array of RNA viruses) [76, 88, 89]\nInvestigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91]\nApproved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94]\nApproved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96]\nApproved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97]\nApproved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98]\nInvestigational Favipiravir (T-705) Nucleoside analog: Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101]\nApproved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104]"}

PMC:7068984 / 25270-27272 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7068984 / 25270-27272 JSON TXT